Cancer-Causing Viruses and Their Inhibitors, Satya Prakash Gupta

Автор: J-M. Foidart; R.J. Muschel
Название: Proteases and Their Inhibitors in Cancer Metastasis
ISBN: 9048161428 ISBN-13(EAN): 9789048161423
Издательство: Springer
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Цена: 213360.00 T
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Описание: In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors.

Автор: Alexey Larionov
Название: Resistance to Aromatase Inhibitors in Breast Cancer
ISBN: 3319179713 ISBN-13(EAN): 9783319179711
Издательство: Springer
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Цена: 130430.00 T
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Описание: Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.

Автор: Sa?d M. Sebti; Andrew D. Hamilton
Название: Farnesyltransferase Inhibitors in Cancer Therapy
ISBN: 1468496069 ISBN-13(EAN): 9781468496062
Издательство: Springer
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Цена: 139750.00 T
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Автор: Ward
Название: STAT Inhibitors in Cancer
ISBN: 3319429477 ISBN-13(EAN): 9783319429472
Издательство: Springer
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Цена: 148020.00 T
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Описание: This volume, which includes contributions from leading scientists and clinicians in the field, provides definitive, state-of-the-art information on STAT inhibitors in a biological and clinical context. It gives an overview of the biology of the STAT family of transcription factors and their role in cancer etiology. Additionally, it describes the raft of therapeutic approaches being used to inhibit STATs in the context of various cancers, covering the full spectrum of therapeutic approaches to inhibiting STATs, and presenting emerging data from clinical trials.

Автор: Nicola J. Curtin; Ricky A. Sharma
Название: PARP Inhibitors for Cancer Therapy
ISBN: 3319141503 ISBN-13(EAN): 9783319141503
Издательство: Springer
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Цена: 158380.00 T
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Описание: PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer.

Автор: A.R. Kennedy; W. Troll
Название: Protease Inhibitors as Cancer Chemopreventive Agents
ISBN: 1461362490 ISBN-13(EAN): 9781461362494
Издательство: Springer
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Цена: 46570.00 T
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Описание: Protease inhibitors (PIs) are widely distributed in plants and animals, and have a variety of functions, which include preventing digestion of seeds by insects and modifying blood clotting in animals.

Автор: Vitaly A. Polunovsky; Peter J. Houghton
Название: mTOR Pathway and mTOR Inhibitors in Cancer Therapy
ISBN: 1617796948 ISBN-13(EAN): 9781617796944
Издательство: Springer
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Цена: 191550.00 T
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Описание: The target of rapamycin (TOR) was rst identi ed in Saccharomyces cerevisiae and subsequently in mammals (mTOR) as a conserved atypical serine/threonine kinase. Rapamycin was isolated as a product of the soil bacteria Streptomyces hygroscopicus, identi ed in a soil sample taken from the island of Rapa Nui (Easter Island).

Автор: Antonio Giordano; Kenneth J. Soprano
Название: Cell Cycle Inhibitors in Cancer Therapy
ISBN: 1617372579 ISBN-13(EAN): 9781617372575
Издательство: Springer
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Цена: 213360.00 T
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Описание: Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases.

Автор: Hoffman, E.J.
Название: Cancer and the Search for Selective Biochemical Inhibitors
ISBN: 0367388936 ISBN-13(EAN): 9780367388935
Издательство: Taylor&Francis
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Цена: 63280.00 T
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Описание:

The world of medicine has become splintered into two factions, that of orthodoxy and its counterpart, alternative or complementary medicine. A problem with alternative medicine is, of course, that of anecdote and hearsay. The solution: the disclosure, in an unassailable fashion, of the underlying biochemical principles for alternative cancer therapies.

Cancer and the Search for Selective Biochemical Inhibitors, Second Edition delineates the underlying biochemical principles for alternative cancer therapies. Completely revised and updated, this edition includes coverage of the link between concepts and practices of alternative and conventional medicine. The author examines anticancer plant substances and other alternatives such as Vitamin C, essiac tea, shark cartilage, and cat's claw. The text also addresses the problem of determining selective and non-toxic enzyme inhibitors for cancer cell metabolic pathways.

While an increased number of allopathic professionals are in tune with alternative therapies, the integration of the two factions is far from the norm. Keeping the same format that made its predecessor a benchmark text, this book compares complementary, alternative, and integrative treatments with chemotherapy and other more traditional treatments.