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Early Drug Development: Bringing a Preclinical Candidate to the Clinic 2 Volume Set, Fabrizio Giordanetto


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Автор: Fabrizio Giordanetto
Название:  Early Drug Development: Bringing a Preclinical Candidate to the Clinic 2 Volume Set
ISBN: 9783527341498
Издательство: Wiley
Классификация:



ISBN-10: 3527341498
Обложка/Формат: Hardcover
Страницы: 816
Вес: 1.87 кг.
Дата издания: 01.08.2018
Серия: Methods and principles in medicinal chemistry
Язык: English
Размер: 248 x 174 x 47
Читательская аудитория: Professional & vocational
Ключевые слова: Clinical & internal medicine,Chemistry
Основная тема: Clinical & internal medicine,Chemistry
Подзаголовок: Bringing a preclinical candidate to the clinic 2 volume set
Ссылка на Издательство: Link
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Поставляется из: Англии
Описание: This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies.
Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues.
After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final section focuses on intellectual property aspects during early clinical development. The emphasis throughout is on recent case studies to exemplify salient points, resulting in an abundance of practice-oriented information that is usually not available from other sources.
Aimed at medicinal chemists in industry as well as academia, this invaluable reference enables readers to understand and navigate the challenges in developing clinical candidate molecules that can be successfully used in phase one clinical trials.


Biosimilars of Monoclonal Antibodies: A Practical Guide to Manufacturing, Preclinical, and Clinical Development

Автор: Liu
Название: Biosimilars of Monoclonal Antibodies: A Practical Guide to Manufacturing, Preclinical, and Clinical Development
ISBN: 1118662318 ISBN-13(EAN): 9781118662311
Издательство: Wiley
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Цена: 171020.00 T
Наличие на складе: Поставка под заказ.
Описание: Addressing a significant need by describing the science and process involved to develop biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar development: preclinical, clinical, regulatory, manufacturing.

Computer-aided design of antimicrobial lipopeptides as prospective drug candidates

Автор: Eswari, Jujjvarapu Satya (national Institute Of Technology, Raipur, India) Dhagat, Swasti (national Institute Of Technology, Raipur, India) Yadav, Man
Название: Computer-aided design of antimicrobial lipopeptides as prospective drug candidates
ISBN: 1138497509 ISBN-13(EAN): 9781138497504
Издательство: Taylor&Francis
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Цена: 178640.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The authors focus on the properties of various lipopeptides which are produced as metabolites by bacteria and have shown to have antimicrobial properties. They provide a step-by-step method in identifying drug molecules for target compounds and testing various properties for drug efficacy. Both experienced researchers and beginners will benefit.

Structural Bioinformatics: Applications in Preclinical Drug Discovery Process

Автор: C. Gopi Mohan
Название: Structural Bioinformatics: Applications in Preclinical Drug Discovery Process
ISBN: 3030052818 ISBN-13(EAN): 9783030052812
Издательство: Springer
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Цена: 158380.00 T
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Описание:

This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking, virtual screening, pharmacophore modeling, molecular dynamics simulations, and residue interaction networks offers insights into pharmacologically active novel molecular entities. It presents a clear concept of the molecular mechanism of different drug targets and explores methods to help understand drug resistance. In addition, it includes chapters dedicated to natural-product- derived medicines, combinatorial drug discovery, the CryoEM technique for structure-based drug design and big data in drug discovery.
The book offers an invaluable resource for graduate and postgraduate students, as well as for researchers in academic and industrial laboratories working in the areas of chemoinformatics, medicinal and pharmaceutical chemistry and pharmacoinformatics.


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