How to Turn Your Company Around or Move It Forward Faster in 90 Days Using a Structured and Proven Step by Step Program, Nielsen Ole L.

Автор: Lund, Ole Nielsen, Morten Lundegaard, Claus Kesmir
Название: Immunological bioinformatics
ISBN: 0262122804 ISBN-13(EAN): 9780262122801
Издательство: MIT Press
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Цена: 59810.00 T
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Using bioinformatics methods to generate a systems-level view of the immune system; description of the main biological concepts and the new data-driven algorithms.

Despite the fact that advanced bioinformatics methodologies have not been used as extensively in immunology as in other subdisciplines within biology, research in immunological bioinformatics has already developed models of components of the immune system that can be combined and that may help develop therapies, vaccines, and diagnostic tools for such diseases as AIDS, malaria, and cancer. In a broader perspective, specialized bioinformatics methods in immunology make possible for the first time a systems-level understanding of the immune system. The traditional approaches to immunology are reductionist, avoiding complexity but providing detailed knowledge of a single event, cell, or molecular entity. Today, a variety of experimental bioinformatics techniques connected to the sequencing of the human genome provides a sound scientific basis for a comprehensive description of the complex immunological processes. This book offers a description of bioinformatics techniques as they are applied to immunology, including a succinct account of the main biological concepts for students and researchers with backgrounds in mathematics, statistics, and computer science as well as explanations of the new data-driven algorithms in the context of biological data that will be useful for immunologists, biologists, and biochemists working on vaccine design. In each chapter the authors show interesting biological insights gained from the bioinformatics approach. The book concludes by explaining how all the methods presented in the book can be integrated to identify immunogenic regions in microorganisms and host genomes.

Автор: Lotte Reedtz Sparrevohn, Poul Otto Nielsen, Ole Thirup Kastholm
Название: Houses for the Living: Volume I-II -- Two-aisled houses from the Neolithic and Early Bronze Age in Denmark
ISBN: 8740832597 ISBN-13(EAN): 9788740832594
Издательство: Gazelle Book Services
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Описание: 6,000 years ago, people began to cultivate the soils of Northern Europe, and with the introduction of agriculture, permanent settlement was adopted. How did these people live, and what was the architecture of their dwellings? This publication will examine the subject. In 2012, we held a conference about two-aisled houses at the SAXO Institute, University of Copenhagen. The aim of the conference was to establish the current state of affairs in terms of research within this area. It soon became clear that an extensive - and largely unpublished - group of source material, which was of great academic interest, existed in Denmark. It was also clear that what was very much required was to gather and present the most important recent results and perspectives in a national summary. This constitutes the basis of this publication, to which all museums in Denmark with archaeological responsibility have contributed. The articles have quite surprisingly indicated that hundreds of longhouses have been excavated. The houses share obvious common traits, but also vary considerably. For example, they include both small houses of only 30m2 and large, almost hall-like houses covering nearly 300m2. Today, there are few areas of Denmark where such houses have not been found. This publication presents the remains of over 1,000 two-aisled houses from more than 500 excavations in Denmark, as well as a few excavations in the northernmost part of Germany. However, throughout this area, a more precise chronological and typological grouping of the houses is still lacking. These questions will be examined in this publication, which apart from articles about the houses in the different parts of the country, also contains a complete catalogue of all the known longhouses dating to the Neolithic and Early Bronze Age in Denmark. Published by The Royal Society of Northern Antiquaries, 2019.