Jiang - HT - Responsible Genomic Data Sharing, Jiang, Xiaoqian
Автор: Strachan Название: Human Molecular Genetics ISBN: 0815345895 ISBN-13(EAN): 9780815345893 Издательство: Taylor&Francis Рейтинг: Цена: 80630.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics, genomics and cell biology.
Maintaining the features that have made previous editions so popular, this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized, coverage of newer DNA sequencing technologies has been expanded, and powerful new gene editing and single-cell genomics technologies have been added. The coverage of GWAS, functional genomics, stem cells, and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation.
Key features:
Fully integrated approach to the molecular aspects of human genetics, genomics, and cell biology
Accessible text is supported and enhanced throughout by superb artwork illustrating the key concepts and mechanisms
Summary boxes at the end of each chapter provide clear learning points
Annotated further reading helps readers navigate the wealth of additional information in this complex subject and provides direction for further study
Reorganized into five sections for improved access to related topics
Also new to this edition - brand new chapter on evolution and anthropology from the authors of the highly acclaimed Human Evolutionary Genetics
A proven and popular textbook for upper-level undergraduates and graduate students, the new edition of Human Molecular Genetics remains the 'go-to' book for those studying human molecular genetics or genomics courses around the world.
Автор: Jonathan Pevsner Название: Bioinformatics and Functional Genomics ISBN: 1118581784 ISBN-13(EAN): 9781118581780 Издательство: Wiley Рейтинг: Цена: 118220.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The bestselling introduction to bioinformatics and genomics now in its third edition Widely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline.
Название: Primer to Analysis of Genomic Data Using R ISBN: 331914474X ISBN-13(EAN): 9783319144740 Издательство: Springer Рейтинг: Цена: 51230.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Through this book, researchers and students will learn to use R for analysis of large-scale genomic data and how to create routines to automate analytical steps. The philosophy behind the book is to start with real world raw datasets and perform all the analytical steps needed to reach final results. Though theory plays an important role, this is a practical book for graduate and undergraduate courses in bioinformatics and genomic analysis or for use in lab sessions. How to handle and manage high-throughput genomic data, create automated workflows and speed up analyses in R is also taught. A wide range of R packages useful for working with genomic data are illustrated with practical examples. The key topics covered are association studies, genomic prediction, estimation of population genetic parameters and diversity, gene expression analysis, functional annotation of results using publically available databases and how to work efficiently in R with large genomic datasets. Important principles are demonstrated and illustrated through engaging examples which invite the reader to work with the provided datasets. Some methods that are discussed in this volume include: signatures of selection, population parameters (LD, FST, FIS, etc); use of a genomic relationship matrix for population diversity studies; use of SNP data for parentage testing; snpBLUP and gBLUP for genomic prediction. Step-by-step, all the R code required for a genome-wide association study is shown: starting from raw SNP data, how to build databases to handle and manage the data, quality control and filtering measures, association testing and evaluation of results, through to identification and functional annotation of candidate genes. Similarly, gene expression analyses are shown using microarray and RNAseq data. At a time when genomic data is decidedly big, the skills from this book are critical. In recent years R has become the de facto< tool for analysis of gene expression data, in addition to its prominent role in analysis of genomic data. Benefits to using R include the integrated development environment for analysis, flexibility and control of the analytic workflow. Included topics are core components of advanced undergraduate and graduate classes in bioinformatics, genomics and statistical genetics. This book is also designed to be used by students in computer science and statistics who want to learn the practical aspects of genomic analysis without delving into algorithmic details. The datasets used throughout the book may be downloaded from the publisher’s website.
Автор: Joseph Seckbach; David J. Chapman Название: Red Algae in the Genomic Age ISBN: 9400732864 ISBN-13(EAN): 9789400732865 Издательство: Springer Рейтинг: Цена: 243800.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: r ed Algae in Genome Age book most people reading this book have childhood memories about being enthralled at the beach with those rare and mysterious living forms we knew as seaweeds.
At a ceremony announcing the completion of the first draft of the human genome in 2000, President Bill Clinton declared, "I believe one of the great truths to emerge from this triumphant expedition inside the human genome is that in genetic terms, all human beings, regardless of race, are more than 99.9 percent the same." Yet despite this declaration of unity, biomedical research has focused increasingly on mapping that.1 percent of difference, particularly as it relates to race.
This trend is exemplified by the drug BiDil. Approved by the FDA in 2005 as the first drug with a race-specific indication on its label, BiDil was originally touted as a pathbreaking therapy to treat heart failure in black patients and help underserved populations. Upon closer examination, however, Jonathan Kahn reveals a far more complex story. At the most basic level, BiDil became racial through legal maneuvering and commercial pressure as much as through medical understandings of how the drug worked.
Using BiDil as a central case study, Kahn broadly examines the legal and commercial imperatives driving the expanding role of race in biomedicine, even as scientific advances in genomics could render the issue irrelevant. He surveys the distinct politics informing the use of race in medicine and the very real health disparities caused by racism and social injustice that are now being cast as a mere function of genetic difference. Calling for a more reasoned approach to using race in biomedical research and practice, Kahn asks readers to recognize that, just as genetics is a complex field requiring sensitivity and expertise, so too is race, particularly in the field of biomedicine.
Автор: Henrich, Vincent Название: Henrich-Managing Patient Health in the Genomic Era ISBN: 0128160152 ISBN-13(EAN): 9780128160152 Издательство: Elsevier Science Рейтинг: Цена: 119030.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
In recent years genomic medicine has grown from a new medical science to an implementable set of clinical methods and technologies whose concrete applications are revolutionizing the health sector. However, most primary care and family health practitioners still have limited experience employing genetic and genomic approaches effectively in their daily practice.
In Managing Patient Health in the Genomic Era: Family Health History and Chronic Disease Risk, Drs. Vincent Henrich, Lori Orlando, and Brian Shirts discuss the practical considerations surrounding the use of genomic and genetic tests to manage patient health, provide adult disease risk assessment, improve diagnosis, and support effective interventions and treatment. In ten chapters, evidence-based information and case studies are described and examine the central place of family health history (FHH) in genomic medicine, tools and strategies for compiling and analysing family health history, how to identify existing and novel genetic markers, how to identify lineage specific (or rare) variants within families, and how to find effective interventions based on genetic testing results and FHH. Factors which influence clinical practice, including gene-environment interactions, FHH social networking, direct to consumer (DTC) genetic testing and data sharing, algorithms for analyzing genetic data, and patient counseling are discussed from the standpoint of clinical practice.
Here frontline healthcare providers will discover succinct commentary and key examples to assist with their local needs. Relevant principles of genetic biology and inheritance are explored and guidance on available support networks and online resources is also provided.
Presents a practical, accessible resource for primary care providers, allied health professionals, pharmacologists, public health professionals, students and clinical researchers
Addresses genetic and genomic approaches in managing patient health, conducting and analyzing family health histories, and assessing adult disease risk
Features an expert author team with direct experience integrating genetics and genomics in primary care and family medicine settings
Examines the attributes and limitations of family health history, genetic testing, and genomic testing in clinical practice
Includes detailed explanations following practice-based examples
Автор: Montesinos Lуpez Osval Antonio, Montesinos Lуpez Abelardo, Crossa Josй Название: Multivariate Statistical Machine Learning Methods for Genomic Prediction ISBN: 3030890090 ISBN-13(EAN): 9783030890094 Издательство: Springer Рейтинг: Цена: 37260.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: It provides an accessible way to understand the theory behind each statistical learning tool, the required pre-processing, the basics of model building, how to train statistical learning methods, the basic R scripts needed to implement each statistical learning tool, and the output of each tool.
Автор: Joseph P Damon Название: Whole Genome Sequencing: Privacy & Security in an Era of Genomic Advancements ISBN: 1631171577 ISBN-13(EAN): 9781631171574 Издательство: Nova Science Рейтинг: Цена: 168950.00 T Наличие на складе: Невозможна поставка. Описание: Over the course of less than a decade, whole genome sequencing has progressed from being one of our nations boldest scientific aspirations to becoming a readily available technique for determining the complete sequence of an individuals deoxyribonucleic acid (DNA) -- that persons unique genetic blueprint. This book focuses on the privacy and progress in whole genome sequencing; and provides a scientific background for policymakers in genetic testing.
Автор: Kollmar Название: Eukaryotic Genomic Databases ISBN: 1493977369 ISBN-13(EAN): 9781493977369 Издательство: Springer Рейтинг: Цена: 125770.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume explores databases containing genome-based data and genome-wide analyses. This book covers databases from all eukaryotic taxa, except plants. The chapters describe database contents and classic use-cases, which assist in accessing eukaryotic genomic data and encouraging comparative genomic research.
Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Eukaryotic Genomic Databases: Methods and Protocols is a valuable resource for geneticists and molecular biologists who are interested in the latest eukaryotic genomics data. The chapters 'PomBase: The Scientific Resource for Fission Yeast' and 'The Ensembl Genome Browser: Strategies for Accessing Eukaryotic Genome Data' are available open access under a CC BY 4.0 license via link.springer.com.
Название: Genomic designing of climate-smart oilseed crops ISBN: 3319935356 ISBN-13(EAN): 9783319935355 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book highlights modern strategies and methods to improve oilseed crops in the era of climate change, presenting the latest advances in plant molecular breeding and genomics-driven breeding. Spectacular achievements in the fields of molecular breeding, transgenics and genomics in the last three decades have facilitated revolutionary changes in oilseed- crop-improvement strategies and techniques. Since the genome sequencing of rice, as the first crop plant, in 2002, the genomes of about one dozen oilseed crops have been sequenced and more are to follow. This has made it possible to decipher the exact nucleotide sequence and chromosomal positions of agroeconomic genes. Most importantly, comparative genomics and genotyping-by-sequencing have opened up new vistas for exploring available biodiversity, particularly of wild crop relatives, for identifying useful donor genes.
Автор: Kishore R. Sakharkar, Meena K. Sakharkar, Ramesh Chandra Название: Post-genomic Approaches in Cancer and Nano Medicine ISBN: 8793102860 ISBN-13(EAN): 9788793102866 Издательство: Taylor&Francis Рейтинг: Цена: 88800.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Understanding the molecular mechanisms of cancer is the key for transforming cancer medicine. Seen in several cancers is a substantial proportion of human genes showing alternative splicing and mis-regulation of Pre-mRNA splicing.
Post-genomic Approaches in Cancer and Nano Medicine further investigates these matters. The first few chapters provide an update on the role of genomics in understanding alternative splicing and targets in cancer pathogenesis. Advances and prospects in applications of nanotechnology for cancer prevention, detection, and treatment are a promising field of research. The subsequent chapters provide insights on how nanotechnology-based therapeutics are moving toward revolutionizing cancer and infectious disease treatment by minimizing toxicity and facilitating targeted delivery of drugs.
Technical topics discussed in the book include: - Alternative splicing and cancer - Cancer imaging - Nanomaterials in infectious diseases - Nanomedicine in oxidative stress and cancer - Nanoparticle based drug delivery systems
Автор: Emmert-Buck Michael R., Rosenberg Avi Z., Tangrea Michael A. Название: Pathological Specimens and Genomic Medicine - Emerging Issues ISBN: 9813276223 ISBN-13(EAN): 9789813276222 Издательство: World Scientific Publishing Рейтинг: Цена: 142560.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Pathological Specimens and Genomic Medicine -- Emerging Issues surveys various fields and medical disciplines related to the implementation of the new field of genomic medicine. The book includes sections on specimen processing, the effects of tissue fixation and storage impact on downstream molecular assays, image analysis and its role in the pathology workflow, molecular evaluation of samples, and how to present data to clinicians. The book contains examples of cases where these innovative technologies are applied in the real world, and also presents a look in to the future of the field of genomic medicine.
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