Автор: Bibekanand Mallick; Zhumur Ghosh Название: Regulatory RNAs ISBN: 3642442846 ISBN-13(EAN): 9783642442841 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Regulatory RNAs are key players in a number of cellular functions and thus are vital to the development of therapeutic and molecular medicine. This comprehensive study of the topic includes theoretical and historical perspectives as well as applications.
Автор: Mathieu Rederstorff Название: Small Non-Coding RNAs ISBN: 1493925466 ISBN-13(EAN): 9781493925469 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Small Non-Coding RNAs
Автор: Baohong Zhang Название: RNAi and Small Regulatory RNAs in Stem Cells ISBN: 1493971069 ISBN-13(EAN): 9781493971060 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Part I: Introduction
1. RNAi Technique in Stem Cell Research: Current Status and Future Perspectives
Gang-Ming Zou
2. RNAi and MicroRNA-Mediated Gene Regulation in Stem Cells
Alexander K. Murashov
Part II: RNA Interference
3. Forward RNAi Screens in Human Hematopoietic Stem Cells
Roman Galeev, Christine Karlsson, Aurйlie Baudet, and Jonas Larsson
4. Silencing of ATP11B by RNAi-Induced Changes in Neural Stem Cell Morphology
5. High-Efficiency Transfection of Glioblastoma Cells and a Simple Spheroid Migration Assay
Carsten Hagemann, Diana Amend, Almuth F. Kessler, Thomas Linsenmann, Ralf-Ingo Ernestus, and Mario Lцhr
6. Construction and Application of Random dsRNA Interference Library for Functional Genetic Screens in Embryonic Stem Cells
Xiaoxing Cheng and Rui Jian
7. Efficient Depletion of Essential Gene Products for Loss-of-Function Studies in Embryonic Stem Cells
Soizik Berlivet, Isabelle Hmitou, Hйlиne Picaud, and Matthieu Gйrard
8. Regulation and/or Repression of Cholinergic Differentiation of Murine Embryonic Stem Cells Using RNAi Directed Against Transcription Factor L3/Lhx8
Takayuki Manabe and Akio Wanaka
9. A Recessive Genetic Screen for Components of the RNA Interference Pathway Performed in Mouse Embryonic Stem Cells
Melanie I. Trombly and Xiaozhong Wang
10. RNAi Knockdown of Ape1 Gene in the Differentiation of Mouse Embryonic Stem Cells
Gang-Ming Zou, Jieqing Yu, Cynthia LeBron, and Yumei Fu
11. An Efficient Transfection Method for Differentiation and Cell Proliferation of Mouse Embryonic Stem Cells
Jun-Yang Liou, Bor-Sheng Ko, and Tzu-Ching Chang
12. Implanting Glioblastoma Spheroids into Rat Brains and Monitoring Tumor Growth by MRI Volumetry
Mario Lцhr, Thomas Linsenmann, Anna Jawork, Almuth F. Kessler, Nils Timmermann, Gyцrgy A. Homola, Ralf-Ingo Ernestus, and Carsten Hagemann
13. RNAi-Based Techniques for the Analysis of Gene Function in Drosophila Germline Stem Cells
Amelia J. Helms, Danielle S. Finger, Victoria L. Hardy, and Elizabeth T. Ables
14. In Vivo RNAi in the Drosophila Follicular Epithelium: Analysis of Stem Cell Maintenance, Proliferation, and Differentiation
Veit Riechmann
15. A Phenotype-Based RNAi Screening for Ras-ERK/MAPK Signaling-Associated Stem Cell Regulators in C. elegans
Myon-Hee Lee and Dong Suk Yoon
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Автор: F. Kenney Название: Gene Expression and its Regulation ISBN: 1468408798 ISBN-13(EAN): 9781468408799 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The Eleventh International Latin American Symposium is an important mile- stone reflecting the rapid development of basic biochemistry in Latin America.
Автор: Riki Kurokawa Название: Long Noncoding RNAs ISBN: 4431555757 ISBN-13(EAN): 9784431555759 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book presents a common principle of actions of long noncoding RNAs (lncRNAs) from points of view at the atomic, molecular and cellular levels. At the atomic level, chemical studies of ribonucleic acids explain the chemical behavior of lncRNAs. Structural biological analysis of lncRNAs and its binding proteins also reveal the precise mechanisms of their actions. Molecular biological approaches lead to insights into molecular mechanisms of these lncRNA actions. At the cellular or individual level of analysis, we grasp the biology and medicine of lncRNAs. These three layers of approaches are thoroughly new and produce novel insights into functions of lncRNAs in living cells. The book consists of five parts: 1) Bioinformatics and other methodologies for lncRNAs, 2) Atomic and molecular structures of lncRNAs, 3) Molecular functions of lncRNAs, 4) Biological actions of lncRNAs, and 5) Potential outcomes for clinical medicine. These sections connect well and work synergistically. The book is for researchers whose specialty is RNA biology and chemistry and also for advanced students at the graduate and undergraduate levels. Readers can grasp the leading edge of lncRNA studies in a comprehensive manner and are inspired to pursue their own particular interests.
Автор: Song Название: The Long and Short Non-coding RNAs in Cancer Biology ISBN: 9811014965 ISBN-13(EAN): 9789811014963 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.
Автор: Nils Walter; Sarah A. Woodson; Robert T. Batey Название: Non-Protein Coding RNAs ISBN: 3540708332 ISBN-13(EAN): 9783540708339 Издательство: Springer Рейтинг: Цена: 231990.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The 2006 Nobel Prize in Physiology or Medicine was awarded to the discoverers of RNA interference, highlighting just one example of a large number of non-protein coding RNAs. This work features chapters in the field of Biophysics of RNA that provide a view of the status of this field.
Автор: Catherine M. Greene Название: MicroRNAs and Other Non-Coding RNAs in Inflammation ISBN: 3319382306 ISBN-13(EAN): 9783319382302 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The book serves as a comprehensive resource for scientists and clinicians studying the role of non-coding RNAs in inflammation (viral infections, wound inflammation), human inflammatory diseases (i.e.
Автор: Christoph Dieterich; Argyris Papantonis Название: Circular RNAs ISBN: 1493975617 ISBN-13(EAN): 9781493975617 Издательство: Springer Рейтинг: Цена: 88500.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This volume provides established approaches for identifying, characterizing, and manipulating circRNAs in vitro, in vivo, and in silico. Chapters highlight the breakthroughs and the challenges in this new field of research. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Circular RNAs: Methods and Protocols aims to useful and informative for further study into this vital field.
Автор: Michael J. Clemens Название: Biochemistry of Cellular Regulation: Gene Expression - Volume I ISBN: 1315891042 ISBN-13(EAN): 9781315891040 Издательство: Taylor&Francis Рейтинг: Цена: 153120.00 T Наличие на складе: Невозможна поставка. Описание: Volume I of this series is focused on the organization of the eukaryotic cell genome, the mechanisms by which its information is transcribed into RNA and translated into protein and the responses of these processes to external influences such as hormones, mitogens and nutritional changes. Aspects of the sub-cellular organization and distribution of newly synthesized gene products are also considered.The Biochemistry of Cellular Regulation series was conceived with the intention of highlighting certain important areas of research which have made significant contributions to our understanding of how higher cells organize and control their activities. Much of the emphasis in the four volumes which comprise this series is on the responses of cells and tissues to their environments.
Автор: Suming Huang Название: Epigenetic Gene Expression and Regulation ISBN: 0127999582 ISBN-13(EAN): 9780127999586 Издательство: Elsevier Science Рейтинг: Цена: 108920.00 T Наличие на складе: Невозможна поставка. Описание:
Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies.
The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues.
The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment.
Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples.
Автор: Marc Feldmann; Andrew McMichael Название: Regulation of Immune Gene Expression ISBN: 0896031047 ISBN-13(EAN): 9780896031043 Издательство: Springer Рейтинг: Цена: 213360.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The immune response gene workshops that took place were based on the need to understand why certain experimental animal strains were high responders and others were low responders. Research in the ensuing years has identified the Ir gene products involved in antibody responses as the la antigens, or MHC Class II antigens.
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