Sialic Acids, Part II: Biological and Biomedical Aspects, Baker, David
Автор: Satya P. Gupta Название: Hydroxamic Acids ISBN: 3662511037 ISBN-13(EAN): 9783662511039 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides comprehensive coverage of the compound class of Hydroxamic Acids, which possess a wide spectrum of biological activities. These are of interest to theoretical and experimental chemists for their potential use in drug design and development.
Автор: Jean-Luc Popot Название: Membrane Proteins in Aqueous Solutions ISBN: 3030103242 ISBN-13(EAN): 9783030103248 Издательство: Springer Рейтинг: Цена: 153720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book is the first to be entirely devoted to the challenging art of handling membrane proteins out of their natural environment, a key process in biological and pharmaceutical research, but one plagued with difficulties and pitfalls. Written by one of the foremost experts in the field, Membrane Proteins in Aqueous Solutions is accessible to any member of a membrane biology laboratory. After presenting the structure, functions, dynamics, synthesis, natural environment and lipid interactions of membrane proteins, the author discusses the principles of extracting them with detergents, the mechanisms of detergent-induced destabilization, countermeasures, and recent progress in developing detergents with weaker denaturing properties. Non-conventional alternatives to detergents, including bicelles, nanodiscs, amphipathic peptides, fluorinated surfactants and amphipols, are described, and their relative advantages and drawbacks are compared. The synthesis and solution properties of the various types of amphipols are presented, as well as the formation and properties of membrane protein/amphipol complexes and the transfer of amphipol-trapped proteins to detergents, nanodiscs, lipidic mesophases, or living cells. The final chapters of the book deal with applications: membrane protein in vitro folding and cell-free expression, solution studies, NMR, crystallography, electron microscopy, mass spectrometry, amphipol-mediated immobilization of membrane proteins, and biomedical applications.Important features of the book include introductory sections describing foundations as well as the state-of-the-art for each of the biophysical techniques discussed, and topical tables which organize a widely dispersed literature. Boxes and annexes throughout the book explain technical aspects, and twelve detailed experimental protocols, ranging from in vitro folding of membrane proteins to single-particle electron cryomicroscopy, have been contributed by and commented on by experienced users.Membrane Proteins in Aqueous Solutions offers a concise, accessible introduction to membrane protein biochemistry and biophysics, as well as comprehensive coverage of the properties and uses of conventional and non-conventional surfactants. It will be useful both in basic and applied research laboratories and as a teaching aid for students, instructors, researchers, and professionals within the field.
Автор: Peter J. Cragg Название: Supramolecular Chemistry ISBN: 9400790481 ISBN-13(EAN): 9789400790483 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The aim of this book is to return to the biomimicry and medicinal potential that inspired many of the early supramolecular chemists and to set it in the context of current advances in the field. The author thus provides a unique perspective on the subject.
Автор: Nikolai L. Vekshin Название: Photonics of Biopolymers ISBN: 3642078559 ISBN-13(EAN): 9783642078552 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Photonics of biopolymers discusses the processes of energy transformation in photoexcited proteins, nucleic acids, membranes and model systems. The author addresses, among other topics: Light absorption, screening and reabsorption; Much of the information stems from the author`s own wide experience in the field.
Автор: Popot Название: Membrane Proteins in Aqueous Solutions ISBN: 3319731467 ISBN-13(EAN): 9783319731469 Издательство: Springer Рейтинг: Цена: 153720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book is the first to be entirely devoted to the challenging art of handling membrane proteins out of their natural environment, a key process in biological and pharmaceutical research, but one plagued with difficulties and pitfalls. Written by one of the foremost experts in the field, Membrane Proteins in Aqueous Solutions is accessible to any member of a membrane biology laboratory. After presenting the structure, functions, dynamics, synthesis, natural environment and lipid interactions of membrane proteins, the author discusses the principles of extracting them with detergents, the mechanisms of detergent-induced destabilization, countermeasures, and recent progress in developing detergents with weaker denaturing properties. Non-conventional alternatives to detergents, including bicelles, nanodiscs, amphipathic peptides, fluorinated surfactants and amphipols, are described, and their relative advantages and drawbacks are compared. The synthesis and solution properties of the various types of amphipols are presented, as well as the formation and properties of membrane protein/amphipol complexes and the transfer of amphipol-trapped proteins to detergents, nanodiscs, lipidic mesophases, or living cells. The final chapters of the book deal with applications: membrane protein in vitro folding and cell-free expression, solution studies, NMR, crystallography, electron microscopy, mass spectrometry, amphipol-mediated immobilization of membrane proteins, and biomedical applications.Important features of the book include introductory sections describing foundations as well as the state-of-the-art for each of the biophysical techniques discussed, and topical tables which organize a widely dispersed literature. Boxes and annexes throughout the book explain technical aspects, and twelve detailed experimental protocols, ranging from in vitro folding of membrane proteins to single-particle electron cryomicroscopy, have been contributed by and commented on by experienced users.Membrane Proteins in Aqueous Solutions offers a concise, accessible introduction to membrane protein biochemistry and biophysics, as well as comprehensive coverage of the properties and uses of conventional and non-conventional surfactants. It will be useful both in basic and applied research laboratories and as a teaching aid for students, instructors, researchers, and professionals within the field.
Автор: Likhtenshtein Gertz Название: Electron Spin Interactions in Chemistry and Biology: Fundamentals, Methods, Reactions Mechanisms, Magnetic Phenomena, Structure Investigation ISBN: 3319816349 ISBN-13(EAN): 9783319816340 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book presents the versatile and pivotal role of electron spin interactions in nature. It provides the background, methodologies and tools for basic areas related to spin interactions, such as spin chemistry and biology, electron transfer, light energy conversion, photochemistry, radical reactions, magneto-chemistry and magneto-biology.
Автор: Valeria Patricia S?lsen; Virginia Susana Martino Название: Sesquiterpene Lactones ISBN: 3030086607 ISBN-13(EAN): 9783030086602 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book addresses chemical and biological aspects related to sesquiterpene lactones (STLs). Experts in different fields have been invited to contribute on this class of compound's chemistry, isolation and identification, biological activities (antibacterial, antifungal, antiviral, antitrypanosomal, antileishmanial,antiplasmodial, antiproliferative and antiinflammatory), synthesis, biosynthesis, derivatization and QSAR analysis. Taxonomic and chemotaxonomic aspects related to the Asteraceae family are also contributed. The book begins by describing the chemical characteristics of STLs, their classification in different skeleton types, synthesis, distribution in nature and their most important biological properties. An overview of the group's main representatives, based on their importance for human health, as well as an update of the most recently isolated STLs, follow. The authors also provide an overview of the most common methods described in the literature for the extraction, purification, identification and structure elucidation of STLs, while also highlighting more recently developed methods. Furthermore, experts in the field provide an in-depth discussion of the most commonly employed in vitro and in vivo antiprotozoal assays against the different stages of parasites, as well as STLs' properties as anticancer agents in numerous cancer cell lines and animal models. Lastly, the book presents examples of the in vitro and in vivo activity of STLs and their mechanism of antiprotozoal action, together with an analysis of ultrastructural alterations, observed using TEM techniques. The book is aimed at scientists working on natural products: both those investigating this particular group of compounds and those who wish to further explore its potential as new drugs for medical conditions such as protozoal diseases and cancer.
Автор: Akitane Mori Название: Guanidines ISBN: 1475707541 ISBN-13(EAN): 9781475707540 Издательство: Springer Рейтинг: Цена: 113190.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In 1978, we had the first research meeting of guanidine compound analysis in Okayama, Japan. The last meeting of the Japan Guanidino Compounds Research Association in 1982 brought together more than 80 members, and about 30 papers were presented there.
Автор: J.D. Andrade Название: Surface and Interfacial Aspects of Biomedical Polymers ISBN: 1468486128 ISBN-13(EAN): 9781468486124 Издательство: Springer Рейтинг: Цена: 87070.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The surface chemistry and physics of polymeric materials is a subject not normally covered to any significant extent in classical surface chemistry textbooks. It moves on to consider the question of the dynamics of polymer surfaces and the implica- tions of polymer surface dynamics on all subsequent characterization and interfacial studies.
Автор: Abderrazzak Douhal Название: Chemistry of silica and zeolite-based materials : ISBN: 0128178132 ISBN-13(EAN): 9780128178133 Издательство: Elsevier Science Рейтинг: Цена: 193130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Chemistry of Silica and Zeolite-Based Materialscovers a wide range of topics related to silica-based materials from design and synthesis to applications in different fields of science and technology. Since silica is transparent and inert to the light, it is a very attractive host material for constructing artificial photosynthesis systems. As an earth-abundant oxide, silica is an ideal and basic material for application of various oxides, and the science and technology of silica-based materials are fundamentally important for understanding other oxide-based materials. The book examines nanosolvation and confined molecules in silica hosts, catalysis and photocatalysis, photonics, photosensors, photovoltaics, energy, environmental sciences, drug delivery, and health.
Written by a highly experienced and internationally renowned team from around the world, Chemistry of Silica and Zeolite-Based Materialsis ideal for chemists, materials scientists, chemical engineers, physicists, biologists, biomedical sciences, environmental scientists, toxicologists, and pharma scientists.
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The enormous versatility of silica for building a large variety of materials with unique properties has been very well illustrated in this book.... The reader will be exposed to numerous potential applications of these materials - from photocatalytic, optical and electronic applications, to chemical reactivity in confined spaces and biological applications. This book is of clear interest not only to PhD students and postdocs, but also to researchers in this field seeking an understanding of the possible applications of meso and microporous silica-derived materials. - Professor Avelino Corma, Institute of Chemical Technology (ITQ-CSIC) and Polytechnical University of Valencia, Spain
Автор: S?lsen Название: Sesquiterpene Lactones ISBN: 3319782738 ISBN-13(EAN): 9783319782737 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
PART I- CHEMICAL AND BIOCHEMICAL ASPECTS
1. Sesquiterpene lactones. Overview (V. Sьlsen, V. Martino - Argentina)
2. Taxonomy (G. Giberti)
3. Biosynthesis and biotechnology (M. Perassolo, J. Rodriguez Talou- Argentina)
4. Chemistry (Francis Barrios - USA)
4.1. Synthesis of sesquiterpene lactones
4.2. Chemical transformation of sesquiterpene lactones
5. Analytical procedures (V. Sьlsen, V. Martino, C. Catalбn - Argentina; S.M. Adekenov- Kazakhstan)
5.1. Extraction and isolation
5.2. Identification. Spectroscopic methods
PART II- BIOLOGICAL ACTIVITIES
6. Trypanocidal and leishmanicidal activities (S. Cazorla, A. Bivona, N. Cerny - Argentina)
7. Mode of action of sesquiterpene lactones on Trypanosoma and Leishmania spp. , (E. Lombardo, M. Sosa, E. Lozano, P. Barrera, R. Spina - Argentina)
7.1. Molecular targets
7.2. Contribution of microscopy for understanding the mechanism of action of sesquiterpene lactones
8. Effect of sesquiterpene lactones on other microorganisms (antibacterial, antifungal, antiviral and antiplasmodial) (authorship to confirm)
9. Antiproliferative and cytotoxic activities (C. Anesini, R. Martino - Argentina)
10. Anti-inflammatory activity (M.R. Alonso)
PART III- SESQUITERPENE LACTONES: MEDICINAL CHEMISTRY APPROACH
11. Structure-activity relationship (T. Schmidt - Germany)
11.3. Structure -anti-inflammatory activity relationship (authorship to confirm)
Автор: Satya P. Gupta Название: Hydroxamic Acids ISBN: 3642381103 ISBN-13(EAN): 9783642381102 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides comprehensive coverage of the compound class of Hydroxamic Acids, which possess a wide spectrum of biological activities. These are of interest to theoretical and experimental chemists for their potential use in drug design and development.
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