CRISPR in Animals and Animal Models, Volume 152, the latest release in the Progress in Molecular Biology and Translational Science series, explores the genome editing CRISPR system in cells and animal models, its applications, the uses of the CRISPR system, and the past, present and future of CRISPR genome editing. Topics of interest in this updated volume include a section on CRISPR history, The genome editing revolution, Programming CRISPR and its applications, CRISPR Delivery methods, CRISPR libraries and screening, CRISPR investigation in haploid cells, CRISPR in the generation of transgenic animals, CRISPR therapeutics, and Promising strategies and present challenges.
Автор: Robert J. Nordstrom (Editor) Название: Translational Research In Biophotonics ISBN: 162841068X ISBN-13(EAN): 9781628410686 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 75770.00 T Наличие на складе: Невозможна поставка. Описание: Translational research transforms scientific discoveries arising from laboratory, clinical, or population studies into clinical applications to reduce cancer incidence, morbidity, and mortality. Optical imaging in medicine is a rapidly growing field, showing promise for delivering new low-cost, point-of-care capabilities with dramatic increases in measurement sensitivity. Unfortunately, despite all of the promises offered by optical imaging, few concepts are making it through the translational pipeline from laboratory demonstration to commercialization for clinical use.The National Cancer Institute of the National Institutes of Health focused a research program on the study of optical imaging for translational advancement into clinical applications for reduction of cancer morbidity and mortality. This book highlights the translational activities of four research groups created for this program, called the Network for Translational Research (NTR). The research leads were Lihong Wang, Eva Sevick-Muraca, Thomas D. Wang, and Christopher Contag. While detailed insight into the nature of the research accomplished at each of these centers is provided, the purpose of this text is to demonstrate that the NTR centers with their industrial partners created significant pathways along the direction of translational research, and that these pathways can now be followed by other researchers seeking to bring these ideas closer to commercial reality. This book will be useful for academic researchers interested in taking concepts and devices beyond the usual ""proof-of-principle"" barrier into areas concerned with good laboratory practices and good manufacturing practices in order to prepare for the translation to FDA discussions.
Автор: Malini Olivo; U. S. Dinish Название: Frontiers in Biophotonics for Translational Medicine ISBN: 9811012466 ISBN-13(EAN): 9789811012464 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Fluorescence Lifetime Spectroscopy and Imaging Techniques in Medical Applications.- Translational Photoacoustic Microscopy.- Advances in Optoacoustic Imaging: From Benchside to Clinic.- Raman Spectroscopy Techniques: Developments and Applications in Translational Medicine.- Deep Tissue Hemodynamic Monitoring Using Diffuse Optical Probes.- High Resolution Optical Coherence Tomography for Bio-imaging.- Handheld Probe-based Dual Mode Ultrasound/Photoacoustics for Biomedical Imaging.- Plasmonic Exosome Biosensors for Medical Diagnostics.- Nanoparticle-enabled Endoscopy: Extending the Frontiers of Diagnosis and Treatment.- Monitoring Free Gas In-situ for Medical Diagnostics Using Laser Spectroscopic Techniques.- Next Frontier in Optical Imaging Techniques for Laparoscopic Surgery: An Industry Perspective.
Автор: Richard Xiao; Xianyao Hu Название: Corpus-Based Studies of Translational Chinese in English-Chinese Translation ISBN: 3642413625 ISBN-13(EAN): 9783642413629 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Поставка под заказ. Описание: This book provides a corpus of translational Chinese which, with a comparable native Chinese corpus, offers a basis for a comprehensive account of the macro-statistic, lexical and grammatical features of translational Chinese in English-to-Chinese translation.
Автор: Martin Wehling Название: Principles of Translational Science in Medicine ISBN: 0128006870 ISBN-13(EAN): 9780128006870 Издательство: Elsevier Science Рейтинг: Цена: 106660.00 T Наличие на складе: Невозможна поставка. Описание: Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. . The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine.
Автор: Robertson, David Название: Clinical and Translational Science ISBN: 0128021012 ISBN-13(EAN): 9780128021019 Издательство: Elsevier Science Рейтинг: Цена: 148220.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science.
Автор: Lyons-Weiler James Название: Cures Vs. Profits: Successes In Translational Research ISBN: 9814730130 ISBN-13(EAN): 9789814730136 Издательство: World Scientific Publishing Рейтинг: Цена: 33790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Did You Ever Wonder Whether Doctors Want Cures, Or Just Treatments?Did You Know ...•Grapefruit Can Interact With Over 100 Drugs, But It May Be Useful For Reducing Blood Pressure And For Weight Loss?•Adhd Over Diagnosis Is Now Recognized Widely As A Fact, And There Are Existing — And New Ways — To Avoid A Misdiagnosis?•Studies Have Been Conducted Demonstrating The Utility Of Omega 3 Fatty Acids, Meditation, Yoga, And Melatonin For Some Important Symptoms Of Adhd, Including Executive Functions?•Vaccines Have Saved Millions Of Lives In The Last Decade?•Breast Cancer Rates Are Declining In The Us, But Have Been Steadily Increasing In Japan?•Doctors Are Getting Better At Predicting Which Chemotherapy Will, And Will Not Work, On Certain Cancers?•There Are Vaccines Against Cancer?This Book Reviews Recent Key, Hard-Won Successes And Findings From Recent Biomedical Research. Written By One Of The Most Ardent Defenders Of The Public Trust In Science, It Provides An Accessible, Detailed Look At Successes In Translational Biomedical And Clinical Research. The Author Provides An Optimistic, Forward-Looking View For The Possibility Of Change For The Public Good, Cutting Through The Controversy And Gets To Very Core Of Each Topic. The Public Can Be Optimistic About The Future Of Medicine, But Only If They Learn The Facts Of These Advances, And Learn What Their Doctors Should Be Expected To Know.Highly Referenced, And Filled With Interviews From Experts And People Directly Involved In The Research Behind The New Facts In Each Chapter, This Book Is A Rich Source Of Information On Advances In Biomedicine That You Will Want To Share With Your Family & Friends.
Автор: Conn, P. Michael Название: Conn`s Translational Neuroscience ISBN: 0128023813 ISBN-13(EAN): 9780128023815 Издательство: Elsevier Science Рейтинг: Цена: 134750.00 T Наличие на складе: Поставка под заказ. Описание:
Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain, ' with the results providing insight into the underlying basis of many neurological disease processes.
This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis.
In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance.
Автор: Marius Erdt; Marius George Linguraru; Cristina Oya Название: Clinical Image-Based Procedures. Translational Research in Medical Imaging ISBN: 3319056654 ISBN-13(EAN): 9783319056654 Издательство: Springer Рейтинг: Цена: 49370.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book constitutes revised selected papers from the International Workshop on Clinical Image-Based Procedures, CLIP 2013, held in conjunction with MICCAI 2012 in Nagoya, Japan, in September 2013.
Автор: Richard Xiao; Xianyao Hu Название: Corpus-Based Studies of Translational Chinese in English-Chinese Translation ISBN: 3662516926 ISBN-13(EAN): 9783662516928 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides a corpus of translational Chinese which, with a comparable native Chinese corpus, offers a basis for a comprehensive account of the macro-statistic, lexical and grammatical features of translational Chinese in English-to-Chinese translation.
Автор: Cristina Oyarzun Laura; Raj Shekhar; Stefan Wesarg Название: Clinical Image-Based Procedures. Translational Research in Medical Imaging ISBN: 3319318071 ISBN-13(EAN): 9783319318073 Издательство: Springer Рейтинг: Цена: 39130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This bookconstitutes revised selected papers from the 4th International Workshop onClinical Image-Based Procedures, CLIP 2015, held in conjunction with MICCAI2015 in Munich, Germany, in October 2015. therefore, the goal of the works presentedin this workshop is to bring basic research methods closer to the clinicalpractice.
Автор: Dennis V. Cokkinos Название: Introduction to Translational Cardiovascular Research ISBN: 3319087975 ISBN-13(EAN): 9783319087979 Издательство: Springer Рейтинг: Цена: 167700.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The term “Translational Research” reflects today’s integration of basic research (“bench”) findings with the clinical practice of medicine, and in a wider scope the application of results from the individual patient (“bedside”) to entire populations for the improvement of public health. This book offers future researchers a stimulus in many aspects of cardiovascular research, so as to promote their interest in future fields of cardiovascular disease, diagnosis and treatment.Introduction to Translational Cardiovascular Research discusses the fundamental and important aspects of the topic. It describes the renin-angiotensin-aldosterone system, the beta adrenergic receptors and the hypothalamic-pituitary-adrenal axis, while covering genetic polymorphisms both generally and specifically as regards the vascular endothelium and the use of microRNAs. As such, this book will be relevant to young physicians, nurses and other scientists engaged in the clinical cardiovascular field who want to added research-oriented dimension to their efforts towards better understanding and practicing of medicine. It also aims to attract young basic researchers who want to develop a better comprehension of the organism as a whole, man or animal, that they are investigating.
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