Название: Rna interference ISBN: 3540751564 ISBN-13(EAN): 9783540751564 Издательство: Springer Рейтинг: Цена: 191560.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In the last few years the major effect that RNAi has had in invertebrate systems is beginning to take hold in mammalian systems through both single gene knockdown experiments and genome-scale screens. Through the introduction of RNAi, mammalian systems have finally gained admittance to the pantheon of model genetic systems.
Автор: Antonio Giuditta; Claire Zomzely-Neurath; Barry B. Название: Role of RNA and DNA in Brain Function ISBN: 1461294274 ISBN-13(EAN): 9781461294276 Издательство: Springer Рейтинг: Цена: 191560.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: There was once an old Chinese man working on a hill with a boy. Suddenly, the old man noticed that a huge wave, far distant in the sea, was approaching the shore endangering all. The villagers were too busy with their own work and paid little heed to the old man, who was considered a bit eccentric.
Автор: Klostermeier Dagmar Название: RNA Structure and Folding ISBN: 3110284596 ISBN-13(EAN): 9783110284591 Издательство: Walter de Gruyter Рейтинг: Цена: 173490.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: While structure-function relationships of proteins have been studied for a long time, structural studies of RNA face additional challenges. Nevertheless, with the continuous discovery of novel RNA molecules with key cellular functions and of novel pathways and interaction networks, the need for structural information of RNA is still increasing. This volume provides an introduction into techniques to assess structure and folding of RNA. Each chapter explains the theoretical background of one technique, and illustrates possibilities and limitations in selected application examples.
Автор: Rick Russell Название: Biophysics of RNA Folding ISBN: 1489988947 ISBN-13(EAN): 9781489988942 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course-grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding.
Автор: Ben-Naim Arieh Название: Molecular Theory Of Water And Aqueous Solutions - Part Ii: The Role Of Water In Protein Folding, Self-Assembly And Molecular Recognition ISBN: 9814350540 ISBN-13(EAN): 9789814350549 Издательство: World Scientific Publishing Рейтинг: Цена: 28510.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Starts out by presenting the evidence for hydrophilic interactions in biochemical processes and then goes on to describe the applications of the hydrophilic interactions in these processes, specifically protein folding, protein association, self assembly and molecular recognition.
Автор: Ben-Naim Arieh Название: Myths And Verities In Protein Folding Theories ISBN: 9814725994 ISBN-13(EAN): 9789814725996 Издательство: World Scientific Publishing Рейтинг: Цена: 29570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This book tells the story of a whole field of research which went disastrously wrong in many different directions when the wrong tools were used and the wrong targets aimed at, to solve a problem.
It all started from the misinterpretation of Schellman's experiments which were carried out in the mid-1950s, and which were later encapsulated by the so-called "Hydrogen-bond inventory argument." As a result, hydrogen bonding was ignored in protein folding; along with that a whole repertoire of other possible hydrophilic effects were not even considered. Against this background the hydrophobic effects, as suggested by Kauzmann, became the single most important effects in protein folding.
In addition, as a result of the misinterpretation of Anfinsen's hypothesis, as well as misunderstanding of the Second Law, people made futile attempts to search for the structure of proteins in the global minimum of either the Energy, or the Gibbs Energy Landscape.
Автор: Walid A. Houry Название: The Molecular Chaperones Interaction Networks in Protein Folding and Degradation ISBN: 1493948644 ISBN-13(EAN): 9781493948642 Издательство: Springer Рейтинг: Цена: 139310.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime.
Автор: Horwich Arthur L Et Al Название: Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell ISBN: 981474932X ISBN-13(EAN): 9789814749329 Издательство: World Scientific Publishing Рейтинг: Цена: 132000.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell.
Автор: Judit Ov?di; Ferenc Orosz Название: Protein folding and misfolding: neurodegenerative diseases ISBN: 9048181275 ISBN-13(EAN): 9789048181278 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Offering all the latest in the study of neurodegenerative diseases, this book reviews the molecular events initiated by unfolded or misfolded proteins leading to conformational human diseases, especially those found in Parkinson`s and Alzheimer`s diseases.
Автор: Ben-Naim Arieh Название: Myths And Verities In Protein Folding Theories ISBN: 9814725986 ISBN-13(EAN): 9789814725989 Издательство: World Scientific Publishing Рейтинг: Цена: 59130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This book tells the story of a whole field of research which went disastrously wrong in many different directions when the wrong tools were used and the wrong targets aimed at, to solve a problem.
It all started from the misinterpretation of Schellman's experiments which were carried out in the mid-1950s, and which were later encapsulated by the so-called "Hydrogen-bond inventory argument." As a result, hydrogen bonding was ignored in protein folding; along with that a whole repertoire of other possible hydrophilic effects were not even considered. Against this background the hydrophobic effects, as suggested by Kauzmann, became the single most important effects in protein folding.
In addition, as a result of the misinterpretation of Anfinsen's hypothesis, as well as misunderstanding of the Second Law, people made futile attempts to search for the structure of proteins in the global minimum of either the Energy, or the Gibbs Energy Landscape.
Автор: Ben-Naim Arieh Название: Molecular Theory Of Water And Aqueous Solutions - Part Ii: The Role Of Water In Protein Folding, Self-Assembly And Molecular Recognition ISBN: 9814350532 ISBN-13(EAN): 9789814350532 Издательство: World Scientific Publishing Рейтинг: Цена: 158400.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Starts out by presenting the evidence for hydrophilic interactions in biochemical processes and then goes on to describe the applications of the hydrophilic interactions in these processes, specifically protein folding, protein association, self assembly and molecular recognition.
Автор: Hargrove, Amanda Название: Hargrove-RNA Recognition V623 ISBN: 0128168315 ISBN-13(EAN): 9780128168318 Издательство: Elsevier Science Рейтинг: Цена: 162820.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
RNA Recognition, Volume 623, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This updated volume covers a variety of topics, including The Preparation of cooperative RNA recognition complexes for crystallographic structural studies, Methods for thermal denaturation studies of fluorogenic aptamers, Dynamic combinatorial chemistry as a rapid, fragment-based approach to RNA-targeted compound discovery, Using a click chemistry assay to identify natural product ligands for pre-microRNAs, Lessons from exploration of chemical and structural small molecule: RNA space, Using ligand-observed NMR to study RNA-small molecule interactions, and much more.
Provides the authority and expertise of leading contributors from an international board of authors
Presents the latest release in the Methods in Enzymology series
Includes the latest information on RNA Recognition
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