Receptor Purification, Gerald Litwack

Название: Receptor and Ion-channel Trafficking: Cell Biology of Ligand-gated and Voltage-sensitive Ion Channels
ISBN: 0192632248 ISBN-13(EAN): 9780192632241
Издательство: Oxford Academ
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Описание: This book reviews the recent advances in our understanding of the the molecular and cellular mechanisms regulating the targeted movement (trafficking) of receptors and ion channels in neurones - mechanisms fundamental to synaptic function.

Автор: Hinrich Gronemeyer; Ulrike Fuhrmann; Karsten Parcz
Название: Molecular Basis of Sex Hormone Receptor Function
ISBN: 3662036916 ISBN-13(EAN): 9783662036914
Издательство: Springer
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Описание: How sex hormone receptors and all the other members of the nuclear receptor superfamily do such a remarkable job has fascinated scientists for decades.

Автор: Gerald Litwack
Название: Receptor Purification
ISBN: 1461267714 ISBN-13(EAN): 9781461267713
Издательство: Springer
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Автор: Hao Wu
Название: TNF Receptor Associated Factors (TRAFs)
ISBN: 1441924205 ISBN-13(EAN): 9781441924209
Издательство: Springer
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Описание:

This book is the only literature that is entirely devoted to TNF Receptor Associated Factors (TRAFs). Almost every aspect of TRAF signaling is covered. The book is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up-to-date on the most recent advances in TRAF signal transduction.

Автор: Derek Leroith; Walter Zumkeller; Robert C. Baxter
Название: Insulin-like Growth Factor Receptor Signalling
ISBN: 0306478463 ISBN-13(EAN): 9780306478468
Издательство: Springer
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Описание: Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. This comprehensive book contains information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.

Автор: Vincent Laudet
Название: The Nuclear Receptor FactsBook,
ISBN: 0124377351 ISBN-13(EAN): 9780124377356
Издательство: Elsevier Science
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Описание: Devoted to nuclear receptors, this work presents an introduction and describes the mode of action of the receptors in general. It also contains detailed entries covering each type of receptor. Entries provide information on: Nomenclature and structure; Isolation; DNA binding properties; Ligands; Expression; Target genes; Knockouts; and more.

Автор: R. J. Lefkowitz
Название: Receptor Regulation
ISBN: 9400958242 ISBN-13(EAN): 9789400958241
Издательство: Springer
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Описание: Elucidation of receptor mechanisms and receptor structure has become the common goal of many scientists from diverse backgrounds. The second group of receptors are the soluble cytoplasmic receptors for the steroid hormones. A third type of hormone receptor is the receptor for the thyroid hormones which appears to be confined to the nucleus.

Автор: Serena Germano
Название: Receptor Tyrosine Kinases
ISBN: 1493954490 ISBN-13(EAN): 9781493954490
Издательство: Springer
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Описание:

Part I: RTKs Activation and Signalling

1. Analysis of Receptor Tyrosine Kinase (RTK) Phosphorylation by Immunoblotting

Martina McDermott and Norma O'Donovan

2. Analysis of Changes in Phosphorylation of Receptor Tyrosine Kinases: Antibody Arrays

Sweta Rani and Lorraine O'Driscoll

3. Analysis of Epidermal Growth Factor Receptor Dimerization by BS³ Crosslinking

Harmony F. Turk and Robert S. Chapkin

4. Single-Molecule Optical Methods Analyzing Receptor Tyrosine Kinase Activation in Living Cells

Inhee Chung and Ira Mellman

5. Evaluation of the Dimerization Profiles of HER Tyrosine Kinases by Time-Resolved Fцrster Resonance Energy Transfer (TR-FRET)

Evelyne Lopez-Crapez, Alexandre Ho-Pun-Cheung, Patrick Garnero, and Hervй Bazin

6. Applying the Proximity Ligation Assay (PLA) to Mouse Preimplantation Embryos for Identifying Protein-Protein Interactions In Situ

Ivan Bedzhov and Marc P. Stemmler

Part II: RTKs Aberrant Expression

7. Analysis of Receptor Tyrosine Kinase Gene Amplification on the Example of FGFR1

Diana Boehm, Anne von Mдssenhausen, and Sven Perner

8. Quantification of the Effects of Mutations on Receptor Tyrosine Kinase (RTK) Activation in Mammalian Cells

Lijuan He and Kalina Hristova

Part III: RTKs Trafficking and Negative Regulation

9. Cell Surface Biotinylation of Receptor Tyrosine Kinases to Investigate Intracellular Trafficking

Mathieu J.F. Crupi, Douglas S. Richardson, and Lois M. Mulligan

10. Studying N-Linked Glycosylation of Receptor Tyrosine Kinases

Harri M. Itkonen and Ian G. Mills

11. Identification of Receptor Protein Tyrosine Phosphatases (RPTPs) as Regulators of Receptor Tyrosine Kinases (RTKs) Using an RPTP siRNA-RTK Substrate Screen

Hojin Lee and Anton M. Bennett

12. Downregulation of Receptor Tyrosine Kinases Through Ubiquitination: Analysis by Immunodetection

Noriaki Shimokawa and Noriyuki Koibuchi

13. Regulation of Receptor Tyrosine Kinases by miRNA: Overexpression of miRNA Using Lentiviral Inducible Expression Vectors

XiangDong Le, Andrew T. Huang, Yunyun Chen, and Stephen Y. Lai

Part IV: RTKs as Pharmacological Targets

14. Human Tumor Xenografts in Mouse as a Model for Evaluating Therapeutic Efficacy of Monoclonal Antibodies or Antibody-Drug Conjugate Targeting Receptor Tyrosine Kinases

Liang Feng, Wei Wang, Hang-Ping Yao, Jianwei Zhou, Ruiwen Zhang, and Ming-Hai Wang

15. Receptor Tyrosine Kinase Targeting in Multicellular Spheroids

Susan Breslin and Lorraine O'Driscoll

16. Receptor Tyrosine Kinases and Drug Resistance: Development and Characterization of In Vitro Models of Resistance to RTK Inhibitors

Claire Corcoran and Lorraine O'Driscoll

Автор: David A. Jans
Название: The Mobile Receptor Hypothesis
ISBN: 1475706820 ISBN-13(EAN): 9781475706826
Издательство: Springer
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Описание: The Role of Membrane Receptor Lateral Movement in Signal Transduction.