Evolving Strategies and Tactics in Membrane Research, D.F. Hoelzl Wallach; R.J. Winzler
Автор: Bernard Testa Название: Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies ISBN: 3906390225 ISBN-13(EAN): 9783906390222 Издательство: Wiley Рейтинг: Цена: 153120.00 T Наличие на складе: Невозможна поставка. Описание: In this age of combinatorial chemistry and high-throughput technologies, bioactive compounds called hits are discovered by the thousands. However, the road that leads from hits to lead compounds and then to pharmacokinetically optimized clinical and drug candidates is very long indeed. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming develop-ment and high rate of attrition of active compounds ultimately doomed by hidden pharmacokinetic defects, drug researchers are coming to incorporate structure-permeation, structure-distribution, structure-metabolism, and structure-toxicity relations into drug-design strategies. To this end, powerful biological, physicochemical, and computational approaches are being developed whose objectives are to increase the clinical relevance of drug design, and to eliminate as soon as possible compounds with unfavorable physicochemical properties and pharmacokinetic profiles. Toxicological issues are also of utmost importance in this paradigm. There was, hence, an urgent need for a book covering this field in an authoritative, didactic, comprehensive, factual, and conceptual manner. In this work of unique breadth and depth, international authorities and practicing experts from academia and industry present the most modern biological, physicochemical, and computational strategies to optimize gastrointestinal absorption, protein binding and distribution, brain permeation, and metabolic profile. The biological strategies emphasized in the book include cell cultures and high-throughput screens. The physicochemical strategies focus on the determination and interpretation of solubility, lipophilicity, and related molecular properties as factors and predictors of pharmacokinetic bahavior. Particular attention is paid to the lipophilicity profiles of ionized compounds, to lipophicity measurements in anisotropic media (liposomes/water, IAM columns), and to permeability across artificial membranes. Computational strategies comprise virtual screening, molecular modelling, lipophilicity, and H-bonding fields and their importance for structure-disposition relations. This book is both about theoretical and technological breakthroughs. Thus, molecular properties are contemplated from a dual perspective, namely a) their interpretation in biological and/or physicochemical terms, and b) their value in screening, lead optimization, and drug-candidate selection. In addition to its 33 chapters, the book includes a CD-ROM containing the invited lectures, oral communications and posters (in full version) presented at the Second LogP Symposium, 'Lipophilicity in Drug Disposition -- Practical and Computational Approaches to Molecular Properties Related to Drug Permeation, Disposition and Metabolism', held at the University of Lausanne in March 2000.
Автор: Carew-Reid, Jeremy Prescott-Allen, Robert Bass, Stephen Dalal-Clayton, Barry Название: Strategies for National Sustainable Development ISBN: 041585086X ISBN-13(EAN): 9780415850865 Издательство: Taylor&Francis Рейтинг: Цена: 20410.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
The IUCN Strategies for Sustainable Development Handbook Series
This handbook is one in a series being produced by IUCN and its partners to assist countries and communities implement Agenda 21, the action programme of the United Nations Conference on Environment and Development. The series will include handbooks on national strategies for sustainable development, local strategies, assessing progress towards sustainability, biodiversity action plans, .involving indigenous peoples, and on integrating population and resource use planning; and regular companion volumes of case studies addressing the key issues of concern to strategy implementation. Many international agreements and action plans now call for countries to undertake national strategies. These strategies seek to involve communities in united approaches to sustainable development. Some are sectoral, such as tropical forest strategies, others are thematic, covering topics such as biodiversity, education or climate change. Still others, such as national conservation strategies and national environment action plans, are evolving to become more comprehensive processes, drawing together economic, social and environmental development actions. This handbook is for people� involved in strategies. It draws on experiences in different regions of the world to present options and examples of the role of strategies in sustainable development. Originally published in 1995
An analysis of two heuristic strategies for the development of mechanistic models, illustrated with historical examples from the life sciences.
In Discovering Complexity, William Bechtel and Robert Richardson examine two heuristics that guided the development of mechanistic models in the life sciences: decomposition and localization. Drawing on historical cases from disciplines including cell biology, cognitive neuroscience, and genetics, they identify a number of "choice points" that life scientists confront in developing mechanistic explanations and show how different choices result in divergent explanatory models. Describing decomposition as the attempt to differentiate functional and structural components of a system and localization as the assignment of responsibility for specific functions to specific structures, Bechtel and Richardson examine the usefulness of these heuristics as well as their fallibility -- the sometimes false assumption underlying them that nature is significantly decomposable and hierarchically organized.
When Discovering Complexity was originally published in 1993, few philosophers of science perceived the centrality of seeking mechanisms to explain phenomena in biology, relying instead on the model of nomological explanation advanced by the logical positivists (a model Bechtel and Richardson found to be utterly inapplicable to the examples from the life sciences in their study). Since then, mechanism and mechanistic explanation have become widely discussed. In a substantive new introduction to this MIT Press edition of their book, Bechtel and Richardson examine both philosophical and scientific developments in research on mechanistic models since 1993.
Автор: Peters B Guy Название: Strategies for Comparative Research in Political Science ISBN: 0230220916 ISBN-13(EAN): 9780230220911 Издательство: Springer Рейтинг: Цена: 40990.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Written by a prominent figure in the field, this book provides an accessible introduction to comparative methodology. Drawing on a wide range of approaches throughout, it is essential reading for anyone wanting to understand or research in this major area of political science.
Автор: Karten Toby J. Название: Inclusion Strategies That Work!: Research-Based Methods for the Classroom ISBN: 1483319903 ISBN-13(EAN): 9781483319902 Издательство: Sage Publications Рейтинг: Цена: 36950.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Students identified for special education services pose a variety of challenges, but this practical resource gives you research-based tools that make differentiating instruction for all students much easier.
Автор: Bland Название: The Research-Productive Department - Strategies From Departments that Excel ISBN: 1882982746 ISBN-13(EAN): 9781882982745 Издательство: Wiley Рейтинг: Цена: 39060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: American society thrives on innovation, which is advanced by the quality and productivity of research from higher education faculty. It is therefore typical for the responsibility of nurturing and sustaining faculty research to fall upon department chairs and deans at postsecondary schools.
Автор: Donald E. Brown; Chelsea C. White III Название: Operations Research and Artificial Intelligence: The Integration of Problem-Solving Strategies ISBN: 0792391063 ISBN-13(EAN): 9780792391067 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In addition to the obvious interest the book should have for members of the operations research and artificial intelligence communities, the papers here are also relevant to members of other research communities and development activities that can benefit from improvements to fundamental problem solving approaches.
Автор: Donald E. Brown; Chelsea C. White III Название: Operations Research and Artificial Intelligence: The Integration of Problem-Solving Strategies ISBN: 9401074887 ISBN-13(EAN): 9789401074889 Издательство: Springer Рейтинг: Цена: 177010.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In addition to the obvious interest the book should have for members of the operations research and artificial intelligence communities, the papers here are also relevant to members of other research communities and development activities that can benefit from improvements to fundamental problem solving approaches.
Автор: Hartvig Dahl; Horst K?chele; Helmut Thom? Название: Psychoanalytic Process Research Strategies ISBN: 364274267X ISBN-13(EAN): 9783642742675 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Hartvig Dahl This is a book about the future that we hope will arouse the curiosity of clinicians and point a direction for researchers.
Автор: Bernard Testa Название: Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies ISBN: 3906390357 ISBN-13(EAN): 9783906390352 Издательство: Wiley Рейтинг: Цена: 239660.00 T Наличие на складе: Поставка под заказ. Описание: Informatics and robotics are the workhorses of a technological revolution in drug research. On them are based combinatorial chemistry, which yields compounds by the many thousands, and high-throughput bioassays, which screen them for activity. The results are avalanches of `hits`, which invade the databases like swarms of locusts.
Автор: Dolicanin, Kajan, Randjelovic & Название: Handbook Of Research On Democratic Strategies And Citizen-Centered E-Government Services ISBN: 1466672668 ISBN-13(EAN): 9781466672666 Издательство: Turpin Рейтинг: Цена: 231610.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Over the past few years, e-government has been rapidly changing the way governmental services are provided to citizens and businesses. These services improve business and government exchange capability, provide a new way to discover and share information, and play a part in the evolution of future technologies.The Handbook of Research on Democratic Strategies and Citizen-Centered E-Government Services seeks to address which services in e-government should be provided to users and how. This premier reference work gives an overview of the latest achievements in the field of e-government services, provides in-depth analysis of and research on the development and deployment of cutting-edge applications, and provides insight into future trends for researchers, teachers, students, government workers, and IT professionals.
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