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The Future of Predictive Safety Evaluation, A.N. Worden; D.V. Parke; J. Marks


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Автор: A.N. Worden; D.V. Parke; J. Marks
Название:  The Future of Predictive Safety Evaluation
ISBN: 9789401079365
Издательство: Springer
Классификация:
ISBN-10: 9401079366
Обложка/Формат: Paperback
Страницы: 320
Вес: 0.45 кг.
Дата издания: 28.12.2011
Язык: English
Размер: 234 x 156 x 17
Основная тема: Biomedicine
Подзаголовок: In Two Volumes Volumes 2
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents.

The Future of Predictive Safety Evaluation

Автор: D.V. Parke; A.N. Worden; J. Marks
Название: The Future of Predictive Safety Evaluation
ISBN: 9401083363 ISBN-13(EAN): 9789401083362
Издательство: Springer
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Цена: 81050.00 T
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Описание: The earliest writings speak of such toxicity and, from the times of ancient Egypt and in the Old Tes- tament, controls have existed[l]. The Royal College of Physicians, for example, was originally established to control the activities of physicians within London.

Predictive Methods in Percutaneous Absorption

Автор: Gary P. Moss; Darren R. Gullick; Simon C. Wilkinso
Название: Predictive Methods in Percutaneous Absorption
ISBN: 3662508311 ISBN-13(EAN): 9783662508312
Издательство: Springer
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Цена: 113180.00 T
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Описание: This book sheds new light on the development and use of quantitative models to describe the process of skin permeation.

Drug Safety Evaluation

Автор: Jean-Charles Gautier
Название: Drug Safety Evaluation
ISBN: 1493971700 ISBN-13(EAN): 9781493971701
Издательство: Springer
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Цена: 139750.00 T
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Описание: Part I: General Toxicology

1. Nonclinical Development of Combination Drugs

Alberto Lodola

2. Juvenile Non-Clinical Safety Studies in Support of Pediatric Drug Development

Paul C. Barrow and Georg Schmitt

Part II: Pathology

3. Procedures of Necropsy and Tissue Sampling

Laurence Fiette, Mohamed Slaoui, and Anne-Laure Bauchet

4. Tissue Sampling and Processing for Histopathology Evaluation

Mohamed Slaoui, Anne-Laure Bauchet, and Laurence Fiette

5. Principles and Methods of Immunohistochemistry

Josй A. Ramos-Vara

6. Applications of Mass Spectrometry Imaging for Safety Evaluation

David Bonnel and Jonathan Stauber

Part III Genetic Toxicology

7. In vivo rat T-lymphocyte Pig-a assay: detection and expansion of cells deficient in the GPI-anchored CD48 surface marker for analysis of mutation in the endogenous Pig-a gene

Vasily N Dobrovolsky, Javier Revollo, Dayton M Petibone, and Robert H Heflich

8. Detection of In Vivo Mutation in the Pig-a Gene of Mouse Bone Marrow Erythroids

Takafumi Kimoto and Daishiro Miura

9. The Use of Bacterial Repair Endonucleases in the Comet Assay

Andrew R. Collins

Part IV Safety Pharmacology

10. Automated Patch-Clamp methods for the hERG Cardiac Potassium Channel

Sylvie Houtmann, Brigitte Schombert, Camille Sanson, Michel Partiseti, and G. Andrees Bohme

11. Impedance Measurement in Induced Pluripotent Stem Cell Derived Cardiomyocytes

Emma-Jane Poulton

Part V Investigative Toxicology

12. Target Safety Assessment: Strategies and Resources

Richard J. Brennan

13. NMR and MS Methods for Metabolomics

Alexander Amberg, Bjцrn Riefke, Gцtz Schlotterbeck, Alfred Ross, Hans Senn, Frank Dieterle, and Matthias Keck

14. Protocols and Applications of Cellular Metabolomics in Safety Studies Using

Precision-Cut Tissue Slices and Carbon 13 NMR

Gabriel Baverel, Maha El Hage, and Guy Martin

15. Statistical Analysis of Quantitative RT-PCR Results

Richard Khan-Malek and Ying Wang

16. Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes

Jean-Pierre Marchandeau and Gilles Labbe

Part VI Screening Assays for Developmental Toxicity

17. FETAX Assay for Evaluation of Developmental Toxicity

Isabelle Mouche, Laure Malйsic, and Olivier Gillardeaux

18. Evaluation of Embryotoxicity Using

Predictive Toxicology in Drug Safety

Автор: Xu
Название: Predictive Toxicology in Drug Safety
ISBN: 0521763649 ISBN-13(EAN): 9780521763646
Издательство: Cambridge Academ
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Цена: 132000.00 T
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Описание: This book is a handbook on drug discovery toxicology for scientists working in this field dedicated to the development of safe drugs. It provides information on the present knowledge of drug side effects and their mitigation strategy during drug discovery, gives guidance for risk assessment and promotes evidence-based toxicology.

Predictive ADMET: Integrated Approaches in Drug Discovery and Development

Автор: Wang
Название: Predictive ADMET: Integrated Approaches in Drug Discovery and Development
ISBN: 1118299922 ISBN-13(EAN): 9781118299920
Издательство: Wiley
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Цена: 142510.00 T
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Описание: By guiding in the application of techniques and tools for predicting ADMET outcomes in drug candidates, Predictive ADMET offers a road map for drug discovery scientists to generate effective and safe drugs for unmet medical needs.

Predictive Drug Testing on Human Tumor Cells

Автор: V. Hofmann; M.E. Berens; G. Martz
Название: Predictive Drug Testing on Human Tumor Cells
ISBN: 3642822975 ISBN-13(EAN): 9783642822971
Издательство: Springer
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Цена: 121110.00 T
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Описание: Predictive drug testing on human tumor cells in order to define the appropriate chemotherapy will remain imperative as long as the anticancer agents available are few in number and show only limited activity.

Preventive and Predictive Genetics: Towards Personalised Medicine

Автор: Godfrey Grech; Iris Grossman
Название: Preventive and Predictive Genetics: Towards Personalised Medicine
ISBN: 3319380575 ISBN-13(EAN): 9783319380575
Издательство: Springer
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Цена: 130590.00 T
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Описание: Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.

Preventive and Predictive Genetics: Towards Personalised Medicine

Автор: Godfrey Grech; Iris Grossman
Название: Preventive and Predictive Genetics: Towards Personalised Medicine
ISBN: 3319153439 ISBN-13(EAN): 9783319153438
Издательство: Springer
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Цена: 149060.00 T
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Описание: Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.

Drug Safety Evaluation.2002

Автор: Gad
Название: Drug Safety Evaluation.2002
ISBN: 0471407275 ISBN-13(EAN): 9780471407270
Издательство: Wiley
Цена: 118270.00 T
Наличие на складе: Невозможна поставка.
Описание: Covers a wide variety of topics, including: acute toxicity testing in pharmaceutical safety evaluation; genotoxicity; safety assessment of inhalant drugs; immunotoxicology in pharmaceutical development; large animal studies; and, evaluation of human tolerance and safety in clinical trials.

Drug Safety Evaluation, 2nd Edition

Автор: Gad
Название: Drug Safety Evaluation, 2nd Edition
ISBN: 0470253169 ISBN-13(EAN): 9780470253168
Издательство: Wiley
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Цена: 167910.00 T
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Описание: Government regulatory agencies must approve any drug before it can be sold. This book presents a road map for safety assessment as an integral part of the development of new drugs and therapeutics. It also addresses specific approaches to evaluating hazards, including problems and solutions.

Drug Safety Evaluation

Автор: Jean-Charles Gautier
Название: Drug Safety Evaluation
ISBN: 1493956698 ISBN-13(EAN): 9781493956692
Издательство: Springer
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Цена: 135090.00 T
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Описание: These meticulous contributions feature key topics such as acute to chronic general toxicity studies, histopathology studies, reproductive toxicity studies, genotoxicity studies, safety pharmacology studies, investigative toxicity studies, and safety biomarker studies.

Safety Evaluation of Pharmaceuticals and Medical Devices

Автор: Shayne C. Gad
Название: Safety Evaluation of Pharmaceuticals and Medical Devices
ISBN: 148998187X ISBN-13(EAN): 9781489981875
Издательство: Springer
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Цена: 130590.00 T
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Описание: The inspiration for this text was the 1988 volume by Alder and Zbinden. Since then, much has changed. But the intent of this volume is to provide similar guidance as to what nonclinical safety assessment tests need to be performed to move a drug into man.


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