The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states.
Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches.
With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments -- endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer.
It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.
Автор: D.G. Hardie Название: Biochemical Messengers: Hormones, Neurotransmitters and Growth Factors ISBN: 0412303507 ISBN-13(EAN): 9780412303500 Издательство: Springer Рейтинг: Цена: 148020.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Argues that cell signalling via nerves, hormones, local mediators and growth factors are not distinct phenomena, but branches of one general mechanism. This volume is designed to act as a bridge between general texts and is aimed at biologists coming to the topic from a variety of backgrounds.
Автор: Lena Claesson-Welsh Название: Vascular Growth Factors and Angiogenesis ISBN: 3642641954 ISBN-13(EAN): 9783642641954 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: FERRARA Vascular Endothelial Growth Factor: Molecular and Biological Aspects . . . . . . . . . . . . . . . . . . . . . . . . . . DIPALMA Structure, Expression and Receptor-Binding Properties of Placenta Growth Factor (PIGF) . . . . . . . . . . . . . . CLAESSON-WELSH Structure and Function of Vascular Endothelial Growth Factor Receptor-I and -2 .
Автор: Mark Bothwell Название: Neuronal Growth Factors ISBN: 3642757499 ISBN-13(EAN): 9783642757495 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Nerve growth factor (NGF) was the first such factor to be characterized (LEVI- MONTALCINI and HAMBURGER 1953) and has served as the model against which all similar factors are compared. These include: three structurally related factors, NGF itself (SCOTT et al. acidic and basic fibroblast growth factors (aFGF, bFGF) (ABRAHAM et al.
Автор: Michael B. Sporn; Anita B. Roberts Название: Peptide Growth Factors and Their Receptors II ISBN: 3642747833 ISBN-13(EAN): 9783642747830 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: With contributions by numerous experts
Автор: Andreas Habenicht Название: Growth Factors, Differentiation Factors, and Cytokines ISBN: 3642748589 ISBN-13(EAN): 9783642748585 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Leading international experts contribute to this selection of reviews covering the merging fields of growth factors, differentiation factors, and cytokines.
Автор: Michael B. Sporn; Anita B. Roberts Название: Peptide Growth Factors and Their Receptors I ISBN: 3642492975 ISBN-13(EAN): 9783642492976 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: With contributions by numerous experts
Автор: Manyonda Название: Immunology Human Reproduction ISBN: 185070791X ISBN-13(EAN): 9781850707912 Издательство: Taylor&Francis Рейтинг: Цена: 178640.00 T Наличие на складе: Невозможна поставка. Описание: The Immunology of Human Reproduction
Автор: Morser Название: Stem Cells in Reproduction and in the Brain. 2006 ISBN: 3540314369 ISBN-13(EAN): 9783540314363 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: What Lessons can Regenerative Medicine Learn From Developmental Biology?- What is a Stem Cell Niche?- New Strategy for Comprehensive Analysis of Gene Functions in ES Cells.-Paternal Dual Barrier by Ifg2-H9 and Dlk1-Gtl2 to parthenogenesis in Mice?- Cell-Cell Fusion as a Means to Establish Pluripotency.- Towards Reprogramming Cells to Pluripotency.- Molecular Switches and Developmental Potential of Adult Stem Cells.- Adult Small Intestinal Stem Cells. Identification, Location, Characteristics and Clinical Applications. Tracking Stem Cells in vivo. Establishment of Nuclear Transfer Embryonic Stem Cell Lines From Adult Somatic Cells by Nuclear Transfer and its Application.- Derivation of Germ Cells From Embryonic Stem Cells.-Germline Recruitment in Mice: A Genetic Program for Epigenetic Reprogramming.- Transplantation of Germ Line Stem Cells for the Study and Manipulation of Spermatogenesis.- Progenitor Cell-Based Myelination as a Model for Cell-Based Therapy of the CNS.- Adult Neural Stem Cells and CNS Repair.- Stem Cell Therapy for Parkinson’s Disease
Название: Exercise and human reproduction ISBN: 1493934007 ISBN-13(EAN): 9781493934003 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Providing a comprehensive review of the interactions between exercise and human reproduction, this unique text focuses on both the positive and negative consequences of sport and physical activity on male and female fertility and infertility and the biological mechanisms and processes behind them. Beginning with a review of the structure and function of the male and female reproductive systems as well as fertilization and gestation, the discussion then turns to the physiology and endocrinology of sport and exercise, which is further elaborated in subsequent chapters on the impact of physical activity, hormonal changes, pathologies, and consequences of drug use for active men and women. Additional chapters address related topics, such as the impact of sport on young athletes and developing reproductive potential, physical activity and pregnancy, the use of oral contraceptives in athletes, oxidative stress, and the impact of nutritional deficiencies on athletes’ fertility, with a final chapter providing recommendations and therapeutic guidelines for exercise-related reproductive disorders. Covering everything from the fundamental principles of sports physiology and human reproductive potential to the interaction between physical exercise and the endocrinology of the reproductive system, Exercise and Human Reproduction is an authoritative resource for helping clinicians understand how the reproductive system adapts to activity and exercise and offers strategies to avoid potential harm to human reproduction.
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