Polyneuropathies Associated with Plasma Cell Dyscrasias, John J. Kelly; Robert A. Kyle; Norman Latov

Автор: Roccaro
Название: Plasma Cell Dyscrasias
ISBN: 3319403184 ISBN-13(EAN): 9783319403182
Издательство: Springer
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Цена: 158380.00 T
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Описание: This book provides a concise overview of the state of the art in the biology and treatment of plasma cell malignancies, a heterogeneous group of diseases primarily characterized by the presence of clonal plasma cells within the bone marrow or extramedullary sites. The plasma cell dyscrasias investigated include monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma, plasmacytoma, immunoglobulin deposition diseases (primary amyloidosis and systemic light and heavy chain deposition diseases), and Waldenstr?m’s macroglobulinemia. In the case of multiple myeloma, the coverage ranges from genomic aberrations and microRNAs to treatment for different patient groups, upcoming novel therapies, immunotherapy, and transplantation. The book reflects the significant research advances achieved in this field during the past few years, which have enhanced our understanding of the molecular mechanisms responsible for the pathogenesis of plasma cell dyscrasias.

Автор: John J. Kelly; Robert A. Kyle; Norman Latov
Название: Polyneuropathies Associated with Plasma Cell Dyscrasias
ISBN: 0898388848 ISBN-13(EAN): 9780898388848
Издательство: Springer
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Цена: 186340.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Plasma cell dyscrasias are common causes of peripheral neuropathy. Peri- pheral neuropathy may be the first manifestation of multiple myeloma, amyloidosis, or monoclonal gammopathy of undetermined significance (MGUS). Peripheral neuropathy occurs in more than one-half of patients with osteosclerotic myeloma. The hematologic disorders are such an important association with peripheral polyneuropathy that, for the last decade, we have obtained a metastatic bone survey and immunoelectrophoresis of serum and a 24-hour urine specimen on all patients older than 40 years with undiagnosed peripheral neuropathy. This textbook on polyneuropathies and plasma cell dyscrasia is welcome, because the subject is of considerable medical importance and because the authors are expert in these disorders. Kelly's studies have shown that a systematic search for monoclonal proteins in plasma and urine among patients with neuropathy of unknown cause increases diagnostic yield. Latov's studies have focused on the role of myelin associated glycoproteins (MAG) in the induction of neuropathy. Kyle, director of the Special Protein Laboratory at Mayo Clinic, brings a broad clinical and laboratory perspective and experi- ence. The timing of the textbook is just right, because there is much new information which needs to be summarized.