Chemical Mutagens, Frederick J. De Serr; A. Hollaender

Автор: Frederick J. De Serr; A. Hollaender
Название: Chemical Mutagens
ISBN: 1461330742 ISBN-13(EAN): 9781461330745
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Описание: In the rapidly developing field of environmental mutagenesis, the use of stand- ardized protocols has permitted the evaluation of large numbers of chemicals for mutagenic and potential carcinogenic activity. In this sixth volume of Chemical Mutagens, the chapters by Perry, Williams, Rosenkranz and Leifer, Kada et al., Pienta, Tazima, Epler, and Rinkus and Legator provide a systematic listing of the chemicals that have been tested, bringing together both unpublished and previously published data. These chapters will serve as an important milestone by providing a convenient reference to tabulated test data with particular assay systems. Another important area of research is the modification of mutagenic activity. In the chapter by Sugimura and Nagao, factors that alter in vitro metabolic activation are discussed, whereas in the chapter by Maher and McCormick, the role of genetic heterogeneity is considered. Equally important is our need to obtain a better understanding of mutation-induction kinetics, and the mathematical analysis by Haynes and Eckardt provides an important step in this direction. An important new approach for the induction of specific locus mutations in human cells in culture is discussed in the chapter by Thilly and co-workers. We have also been concerned about the problems in the practical applica- tion of various short-term tests in commerical testing laboratories. The prob- lems emerging in the evaluation of potentially important new chemicals have been discussed in a chapter by Brusick et al.

Автор: Alexander Hollaender
Название: Chemical Mutagens
ISBN: 1461589711 ISBN-13(EAN): 9781461589716
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Описание: For this reason, I think that somatic tests are preferable to germinal tests, despite the fact that it is germinal mutations which are feared.

Автор: Alexander Hollaender; Frederick J. de Serres
Название: Chemical Mutagens
ISBN: 1461292670 ISBN-13(EAN): 9781461292678
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Описание: Origin of Colonies . Life Cycle . Colony Maintenance . Pathology . Allergy to Grasshoppers . Grasshopper Egg, Embryo, and Cells . The Egg Shell and Membranes . Embryonic Development . Cells . Preparation of Embryos for Cell Analysis . Response of the Grasshopper Neuroblast to Mutagens . Reproducibility of Data . Chemical Mutagens .

Автор: Frederick J. De Serr; A. Hollaender
Название: Chemical Mutagens
ISBN: 1461336961 ISBN-13(EAN): 9781461336969
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Описание: Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The Classical Approach: Phenotypic Monitoring . . . . . . . Monitoring for Changes in Gene Products . . . . Drug-Resistant Lymphocytes . Hemoglobin Variants . Nongenetic Indicators of Mutagen Exposure . Alkylation of Proteins . DNA Damage .

Автор: Alexander Hollaender
Название: Chemical Mutagens
ISBN: 1461589746 ISBN-13(EAN): 9781461589747
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Описание: The ready acceptance and wide demand for copies of the first two volumes of Chemical Mutagens: Principles and Methods Jar Their Detection have demon- strated the need for wider dissemination of information on this timely and urgent subject.

Автор: Alexander Hollaender
Название: Chemical Mutagens
ISBN: 1461589681 ISBN-13(EAN): 9781461589686
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Описание: Its Panel on Mutagenicity recommends that all currently used pesticides be tested for mutagenicity in several recently developed and relatively simple systems.

Автор: Alexander Hollaender
Название: Chemical Mutagens
ISBN: 1468408941 ISBN-13(EAN): 9781468408942
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Автор: Beatrice Singer; D. Grunberger
Название: Molecular Biology of Mutagens and Carcinogens
ISBN: 1461337747 ISBN-13(EAN): 9781461337744
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Описание: This book originated in numerous Gordon Research Conferences and many other meetings of scientists working in chemistry, biophysics, biochemistry, and biology related to mutagenesis and carcinogenesis.

Автор: F.A. Beland; L.G. Cain; J.S. Felton; J.D. Groopman
Название: Chemical Carcinogenesis and Mutagenesis I
ISBN: 3642747779 ISBN-13(EAN): 9783642747779
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Описание: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin- Madison.

Автор: F. Vogel; G. R?hrborn
Название: Chemical Mutagenesis in Mammals and Man
ISBN: 3642858767 ISBN-13(EAN): 9783642858765
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Описание: Encouraged by the results with radiation genetics, the editors of this volume have tried since 1963 to organize a team of scientists in Heidelberg who would examine the problem of chemical mutagenesis in mammals with a variety of methods. Meanwhile, other organizations have also become interested in this problem and various teams, particularly in the U.S.A., but also in West Germany, are working in this field. This development is very auspicious; the spectrum of our methods does permit limited conclusions as to the mutagenic effects of chemical substances in mammals, but we are still far away from a thorough determination of all the genetically relevant effects. New methods must be developed. This volume is the result of a request by the Chairman of the "Gesellschaft fUr Anthropologie und Humangenetik", Frau Professor Dr. I. SCHWIDETZKY (Mainz), that one of us (F.V.) organize a symposium concerning mutation research in the framework of its annual meeting on October 7, 1969. The most sensible approach seemed to be one of centering the discussion on the test methods employed in mutagenicity research with mammals. With the aid of the Deutsche Forschungsgemeinschaft and the pharma- ceutical industry it was possible to invite scientists from the U.S.A. We wish to thank Firma Thomae, Biberach, Firma Bayer, Leverkusen, and Firma Boehringer, Mannheim, for their contributions. We wish to thank Dr. HAsso SCHROEDER especially for his efforts on our behalf.

Автор: Frederick De Serres
Название: Comparative Chemical Mutagenesis
ISBN: 146133411X ISBN-13(EAN): 9781461334118
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Описание: ) 27709 The Workshop on Comparative Chemical Mutagenesis was orga- nized to begin the process of problem identification and resolution concerning our needs to evaluate the data on test chemicals arising from assays for mutagenic activity on laboratory organisms.

Автор: C.F. Arlett; Colin S. Cooper; Philip L. Grover; D.
Название: Chemical Carcinogenesis and Mutagenesis II
ISBN: 3642747809 ISBN-13(EAN): 9783642747809
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Описание: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin- Madison.