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Adenosine and Adenosine Receptors, Michael Williams


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Автор: Michael Williams
Название:  Adenosine and Adenosine Receptors
ISBN: 9781461288503
Издательство: Springer
Классификация:

ISBN-10: 1461288509
Обложка/Формат: Paperback
Страницы: 516
Вес: 0.70 кг.
Дата издания: 04.10.2011
Серия: The Receptors
Язык: English
Размер: 229 x 152 x 27
Основная тема: Biomedicine
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: Historically, the major emphasis on the study of purinergic systems has been predominantly in the areas of physiology and gross pharmacology. The last decade has seen an exponential in- crease in the number of publications related to the role of both adenosine and A TP in mammalian tissue function, a level of interest that has evolved from a more molecular focus on the identity of adenosine and A TP receptor subtypes and the search for selective ligands and development of radioligand binding assays by Fred Bruns and colleagues (especially that for A receptors) that played z a highly significant role in advancing research in the area. In the 60 years since adenosine was first shown to be a potent hypotensive agent, a considerable investment has been made by several pharmaceutical companies-including Abbott, Byk Gulden, Takeda, Warner-LambertlParke Davis, Boehringer Mann- heim, Boehringer Ingelheim, Nelson/Whitby Research and CffiA- Geigy-as well as John Dalys laboratory at the National Institutes of Health, to design new adenosine receptor ligands, and both agon- ists and antagonists with the aim of developing new therapeutic entiities. Numerous research tools have derived from these efforts including: 2-chloroadenosine, R-PIA ( -phenylisopropyladeno- sine; NECA (5 N-ethylcarboxamidoadenosine); CV1808; CI936; PD 125,944; -benzyladenosine; PACPX; CPX; CPT; XAC; CGS 15943 and CGS 21680. Yet in the realm of therapeutics it was only in 1989 that adenosine itself was approved for human use in the treatment of supraventricular arrythmias.

The Adenosinergic System

Автор: Micaela Morelli; Nicola Simola; Jadwiga Wardas
Название: The Adenosinergic System
ISBN: 3319202723 ISBN-13(EAN): 9783319202723
Издательство: Springer
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Цена: 149060.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

Adenosine A2A receptors: localization and function.- Allosteric Mechanisms in the adenosine A2A-dopamine D2 receptor heteromer.- Adenosine A2A receptor antagonists in drug development.- Adenosine A2A Receptors and Neurotrophic Factors: Relevance for Parkinson's Disease.- Role of adenosine A2A receptors in the control of neuroinflammation - relevance for Parkinson's disease.- Purines in Parkinson's: Adenosine A2A receptors and urate as targets for neuroprotection.- Adenosine A2A receptor antagonists as drugs for symptomatic control of Parkinson's disease in preclinical studies.- Dopamine/adenosine interactions related to tremor in animal models of Parkinsonism.- Adenosine A2A receptor antagonists in L-DOPA-induced motor fluctuations.- Adenosine A2A receptor-mediated control of non-motor functions in Parkinson's disease.- Imaging Studies with A2A Receptor Antagonists.- Caffeine and neuroprotection in Parkinson's disease.- The story of istradefylline - the first approved A2A antagonist for the treatment of Parkinson's disease.- Adenosinergic Receptor Antagonists: Clinical Experience in Parkinson's Disease.- Adenosinergic regulation of sleep-wake behavior in the basal ganglia.


Adenosine

Автор: Susan Masino; Detlev Boison
Название: Adenosine
ISBN: 148998755X ISBN-13(EAN): 9781489987556
Издательство: Springer
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Цена: 191550.00 T
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Описание: Following on new understanding of its influence in dopaminergic disorders, sleep and epilepsy, this book collects recent research on regulating the influence of adenosine, outlines clinical implications, and highlights emerging adenosine-based therapies.

Adenosine Receptors in Neurodegenerative Diseases

Автор: Blum, David
Название: Adenosine Receptors in Neurodegenerative Diseases
ISBN: 0128037245 ISBN-13(EAN): 9780128037249
Издательство: Elsevier Science
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Цена: 117900.00 T
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Описание:

Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeutics. The book provides an up-to-date overview by the best specialists in the field, helping readers consider the importance of adenosine and expand the global impact and visibility of adenosine research in the CNS field.

Chapters include adenosine biology and signaling, gene regulation, control of motor function, and novel adenosine-based therapies in the CNS. It is an ideal resource for researchers, advanced graduate students, clinicians, and industry scientists working in the fields of clinical neuroscience and molecular and cellular neuroscience.



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