Coordinated Regulation of Gene Expression, R. Clayton
Автор: Zhang Название: RNAi and microRNA-Mediated Gene Regulation in Stem Cells ISBN: 1607617684 ISBN-13(EAN): 9781607617686 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This cutting-edge text will be a valuable resource for scientists and aspiring graduate students interested in the intersection of RNAi, miRNA, and stem cell molecular biology and exciting areas of research such as regenerative medicine and cancer.
Автор: Wajapeyee Название: Eukaryotic Transcriptional and Post-Transcriptional Gene Expression Regulation ISBN: 1493965166 ISBN-13(EAN): 9781493965168 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume describes a variety of protocols that will allow the readers to study different aspects of transcriptional and posttranscriptional gene expression regulation in eukaryotic cells. Chapters focus on the latest use of CRISPRi and RNAi technologies for studying various aspects of transcriptional and posttranscriptional regulation and tools to navigate protocols on key bioinformatics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfallsAuthoritative and cutting-edge, Eukaryotic Transcription and Post-Transcription Gene Expression Regulation aims to ensure successful results in the further study of this vital field.
Автор: Gary H. Perdew; Jack P. Vanden Heuvel; Jeffrey M. Название: Regulation of Gene Expression ISBN: 1627038086 ISBN-13(EAN): 9781627038089 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http://moltox. cas. psu. edu and select “Courses. ” The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.
Автор: J. Ilan Название: Translational Regulation of Gene Expression ISBN: 146845367X ISBN-13(EAN): 9781468453676 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Given the accelerated growth of knowledge in the field of gene expression, it seemed timely to discuss current developments in the area of translational reg- ulation of gene expression as well as to evaluate emerging technology. Translational regulation occurs with prokaryotic as well as with eukaryotic messenger RNA (mRNA) in vivo and in vitro. In prokaryotes, through genetic manipulations and mutagenesis, the mechanisms are much better understood, as for example the mechanism of attenuation. In bacteria, different translational efficiencies for the same mRNA may vary by lOOO-fold. Translational regulation was first observed in 1966 with RNA phages of Escherichia coli by Lodish and Zinder. However, translational regulation of proteins from DNA genomes is also well described for bacteria, as for example gene 32 protein of bacteriophage T4 and E. coli ribosomal proteins. In eukaryotes, the utilization of an individual mRNA species with different efficiencies is poorly understood. For example, mRNA for ribosomal proteins is translationally regulated during Drosophila oogenesis, without any clue to the mechanism involved. It was observed that ribosomal protein mRNA during Drosophila oogenesis and embryogenesis is selectively on or off the polysomes during different developmental stages. In contrast, bacterial ribosomal protein is also translationally regulated by autogenous regulation. The mechanism is well understood and involves binding of the gene product to its transcript in competition with rRNA.
Автор: Luis Carrasco; Nahum Sonenberg; Eckard Wimmer Название: Regulation of Gene Expression in Animal Viruses ISBN: 1461362717 ISBN-13(EAN): 9781461362715 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of a NATO ASI held in Mallorca, Spain, May 30-June 8, 1992
Автор: J. Ilan Название: Translational Regulation of Gene Expression 2 ISBN: 1461362547 ISBN-13(EAN): 9781461362548 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book, which results from the dramatic increase in interest in the control mechanism employed in gene expression and the importance of the regulated proteins, presents new information not covered in Translational Regulation of Gene Expression, which was published in 1987.
Автор: Ma Название: Regulation of Cytokine Gene Expression in Immunity and Diseases ISBN: 940240919X ISBN-13(EAN): 9789402409192 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book explores the major cytokines, such as IL-1 and IFN-?, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presenting cutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.
Автор: Suming Huang Название: Epigenetic Gene Expression and Regulation ISBN: 0127999582 ISBN-13(EAN): 9780127999586 Издательство: Elsevier Science Рейтинг: Цена: 108920.00 T Наличие на складе: Невозможна поставка. Описание:
Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies.
The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues.
The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment.
Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples.
Автор: J. E. Celis Название: Gene Expression in Normal and Transformed Cells ISBN: 146844543X ISBN-13(EAN): 9781468445435 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The concluding section deals with various aspects of gene expression in normal and transformed cells with special emphasis given to studies using two dimensional gel electrophoresis, cell hybridization, gene transfer and immunological techniques.
Автор: Giovanni Parmigiani; Elizabeth S. Garett; Rafael A Название: The Analysis of Gene Expression Data ISBN: 1475781245 ISBN-13(EAN): 9781475781243 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book presents practical approaches for the analysis of data from gene expression micro-arrays. The book includes coverage of various packages that are part of the Bioconductor project and several related R tools. The materials presented cover a range of software tools designed for varied audiences.
Автор: Jean M. Lauder Название: Gene Expression and Cell-Cell Interactions in the Developing Nervous System ISBN: 1468448706 ISBN-13(EAN): 9781468448702 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book seeks to emphasize the importance of molecular technology in the study of neurogenetic mechanisms and to explore the possible relationships between specific cell- cell interactions and regulated gene expression in the develop- ing nervous ~stem.
Автор: John E.G. McCarthy; Mick F. Tuite Название: Post-Transcriptional Control of Gene Expression ISBN: 3642751415 ISBN-13(EAN): 9783642751417 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the NATO/CEC Advanced Research Workshop on Post-Transcriptional Control of Gene Expression, held in Goslar, FRG, April 6-12, 1990
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