Advanced Physicochemical Treatment Processes, Lawrence K. Wang; Yung-Tse Hung; Nazih K. Shammas
Автор: Lawrence K. Wang; Yung-Tse Hung; Nazih K. Shammas Название: Advanced Physicochemical Treatment Technologies ISBN: 1617378097 ISBN-13(EAN): 9781617378096 Издательство: Springer Рейтинг: Цена: 174130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In Advanced Physiochemical Treatment Technologies, leading pollution control educators and practicing professionals describe how various combinations of different cutting-edge process systems can be arranged to solve air, noise, and thermal pollution problems.
Автор: Herwig J. Hilderson; Gregory B. Ralston Название: Physicochemical Methods in the Study of Biomembranes ISBN: 1461357578 ISBN-13(EAN): 9781461357575 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In mammalian cells many physiological processes rely on the dynamics of the organization of lipids and proteins in biological membranes.
Автор: Bernard Testa Название: Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies ISBN: 3906390225 ISBN-13(EAN): 9783906390222 Издательство: Wiley Рейтинг: Цена: 153120.00 T Наличие на складе: Невозможна поставка. Описание: In this age of combinatorial chemistry and high-throughput technologies, bioactive compounds called hits are discovered by the thousands. However, the road that leads from hits to lead compounds and then to pharmacokinetically optimized clinical and drug candidates is very long indeed. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming develop-ment and high rate of attrition of active compounds ultimately doomed by hidden pharmacokinetic defects, drug researchers are coming to incorporate structure-permeation, structure-distribution, structure-metabolism, and structure-toxicity relations into drug-design strategies. To this end, powerful biological, physicochemical, and computational approaches are being developed whose objectives are to increase the clinical relevance of drug design, and to eliminate as soon as possible compounds with unfavorable physicochemical properties and pharmacokinetic profiles. Toxicological issues are also of utmost importance in this paradigm. There was, hence, an urgent need for a book covering this field in an authoritative, didactic, comprehensive, factual, and conceptual manner. In this work of unique breadth and depth, international authorities and practicing experts from academia and industry present the most modern biological, physicochemical, and computational strategies to optimize gastrointestinal absorption, protein binding and distribution, brain permeation, and metabolic profile. The biological strategies emphasized in the book include cell cultures and high-throughput screens. The physicochemical strategies focus on the determination and interpretation of solubility, lipophilicity, and related molecular properties as factors and predictors of pharmacokinetic bahavior. Particular attention is paid to the lipophilicity profiles of ionized compounds, to lipophicity measurements in anisotropic media (liposomes/water, IAM columns), and to permeability across artificial membranes. Computational strategies comprise virtual screening, molecular modelling, lipophilicity, and H-bonding fields and their importance for structure-disposition relations. This book is both about theoretical and technological breakthroughs. Thus, molecular properties are contemplated from a dual perspective, namely a) their interpretation in biological and/or physicochemical terms, and b) their value in screening, lead optimization, and drug-candidate selection. In addition to its 33 chapters, the book includes a CD-ROM containing the invited lectures, oral communications and posters (in full version) presented at the Second LogP Symposium, 'Lipophilicity in Drug Disposition -- Practical and Computational Approaches to Molecular Properties Related to Drug Permeation, Disposition and Metabolism', held at the University of Lausanne in March 2000.
Автор: K. L. Mittal Название: Physicochemical Aspects of Polymer Surfaces ISBN: 1461575869 ISBN-13(EAN): 9781461575863 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This and its companion Volume 2 document the proceedings of the International Symposium on Physicochemical Aspects of Polymer Surfaces held under the auspices of the American Chemical Society in New York City, August 23-28, 1981.
Автор: Jacques Huyghe; Peter A.C. Raats; Stephen C. Cowin Название: IUTAM Symposium on Physicochemical and Electromechanical, Interactions in Porous Media ISBN: 9048169844 ISBN-13(EAN): 9789048169849 Издательство: Springer Рейтинг: Цена: 213360.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The purpose of the IUTAM symposium from which this proceedings volume has been compiled was to dive deep into the mechanics of those porous media that involve mechanics and chemistry, mechanics and electromagnetism, mechanics and thermal fluctuations of mechanics and biology.
Автор: Alan A. Boulton; Glen B. Baker; Donald P. J. Boisv Название: Imaging and Correlative Physicochemical Techniques ISBN: 1489941118 ISBN-13(EAN): 9781489941114 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Казахстан, 010000 г. Астана, проспект Туран 43/5, НП2 (офис 2) ТОО "Логобук" Тел:+7 707 857-29-98 ,+7(7172) 65-23-70 www.logobook.kz
