Nucleic Acids Hybridization, Anton Buzdin; Sergey Lukyanov

Автор: M. A. Hayat
Название: Handbook of Immunohistochemistry and in Situ Hybridization of Hum
ISBN: 0123339421 ISBN-13(EAN): 9780123339423
Издательство: Elsevier Science
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Цена: 218960.00 T
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Описание: Discusses various aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. This book explains the principles and applications of techniques used in the field of molecular genetics. It also translates molecular genetics into cancer diagnosis.

Название: FISH (Fluorescence in Situ Hybridization)
ISBN: 0199638845 ISBN-13(EAN): 9780199638840
Издательство: Oxford Academ
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Цена: 126720.00 T
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Описание: FISH (Fluorescence In Situ Hybridization) is a versatile technique that is constantly being applied to branches of research. With over 100 protocols, this book will be of significant interest to students and technicians in both clinical service and basic science laboratories who employ genetic or genomic technologies.

Автор: M. A. Hayat
Название: Handbook of Immunohistochemistry and in Situ Hybridization of Hum
ISBN: 0123339413 ISBN-13(EAN): 9780123339416
Издательство: Elsevier Science
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Цена: 218960.00 T
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Описание: Discusses various aspects of immunohistochemistry and in situ hybridization technologies and the role they play in reaching a cancer diagnosis. This work provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, and the benefits and limitations of each method.

Автор: Liehr
Название: Fluorescence In Situ Hybridization (FISH)
ISBN: 3662529572 ISBN-13(EAN): 9783662529577
Издательство: Springer
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Цена: 130430.00 T
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Описание: This manual offers detailed protocols for fluorescence in situ hybridization (FISH) and comparative genomic hybridization approaches, which have been successfully used to study various aspects of genomic behavior and alterations. Methods using different probe and cell types, tissues and organisms, such as mammalians, fish, amphibians (including lampbrush-chromosomes), insects, plants and microorganisms are described in 57 chapters. In addition to multicolor FISH procedures and special applications such as the characterization of marker chromosomes, breakpoints, cryptic aberrations, nuclear architectures and epigenetic changes, as well as comparative genomic hybridization studies, this 2nd edition describes how FISH can be combined with other techniques. The latter include immunostaining, electron microscopy, single cell electrophoresis and microdissection. This well-received application guide provides essential protocols for beginning FISHers and FISH experts alike working in the fields of human genetics, microbiology, animal and plant sciences.

Автор: Joanna M. Bridger; Keith Morris
Название: Fluorescence in situ Hybridization (FISH)
ISBN: 1493957244 ISBN-13(EAN): 9781493957248
Издательство: Springer
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Цена: 139750.00 T
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Описание: Fluorescence in situ Hybridization (FISH) belongs to that special category of well-established molecular biology techniques that, since their inception a few decades ago, have succeeded in keeping a prominent position within the constantly expanding list of laboratory pro- dures for biomedical research and clinical diagnostics. The design simplicity and cost-effectiveness of the early FISH protocols, combined with the signifcant acceleration of discoveries in related technical areas such as fuor- cence microscopy, digital imaging, and nucleic acid technology have prompted the div- sifcation of the original technique into an outstanding number of imaginative and useful applications, and thus have not only held back its outmoding but have also promoted its expansion into different areas of basic and applied research in the post-genomic era. The 34 chapters included in this book aim at portraying the vibrant complexity and diversity of the current FISH protocol landscape, providing cutting-edge examples of va- ous applications for genetic and developmental research, cancer research, reproductive medicine, diagnostic and prognostic purposes, microbial ecology, and evolutionary st- ies. The book is divided in four parts: (I) Core Techniques, (II) Technical Advancements and Novel Adaptations, (III) Translational FISH: Applications for Human Genetics and Medicine, and (IV) Protocols for Model Organisms.

Автор: Ashley T. Haase; Michael B.A. Oldstone
Название: In Situ Hybridization
ISBN: 3642744273 ISBN-13(EAN): 9783642744273
Издательство: Springer
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Цена: 121110.00 T
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Описание: Leading researchers present contemporary treatment of in situ hybridization applied to current issues in animal virus pathogenesis. The genetic programs played out in these cells and the newer methods of hybridization at the electron microscopic level provide valuable insight into the complexities of virus-host interaction.

Автор: Diponkar Banerjee; Sohrab P. Shah
Название: Array Comparative Genomic Hybridization
ISBN: 1493959557 ISBN-13(EAN): 9781493959556
Издательство: Springer
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Цена: 135090.00 T
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Описание: This Methods in Molecular Biology (TM) book explores the scope of what is possible today in documenting abnormalities associated with several human cancers. Offers materials and reagents lists, step-by-step protocols, troubleshooting tips, pitfalls and more.

Автор: G.R. Coulton; J. de Belleroche
Название: In Situ Hybridization: Medical Applications
ISBN: 940105326X ISBN-13(EAN): 9789401053266
Издательство: Springer
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Цена: 93160.00 T
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Описание: In situ hybridization has developed as a means of localizing specific DNA and RNA sequences within tissues. Complementary DNA, RNA or oligonucleotide probes, suitably labelled, are hybridized to specific DNA or RNA targets within tissues.

Автор: Peter B. Gahan
Название: Circulating Nucleic Acids in Plasma and Serum
ISBN: 9400790414 ISBN-13(EAN): 9789400790414
Издательство: Springer
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Цена: 204040.00 T
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Описание: DNA and RNA fractions have been isolated from the whole blood, serum, plasma, the surface of blood cells, urine, saliva and spinal fluid from both healthy individuals and clinical patients. Recent developments are presented concerning the isolation, quantification and analysis of these molecules and their use in the identification of specific nucleic acid fragments related to a variety of clinical disorders thereby permitting their early diagnosis and prognosis.

Автор: Jurga
Название: Modified Nucleic Acids in Biology and Medicine
ISBN: 3319341731 ISBN-13(EAN): 9783319341736
Издательство: Springer
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Цена: 158380.00 T
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Описание: This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.

Автор: Christopher Janson; Matthew During
Название: Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules
ISBN: 1489986448 ISBN-13(EAN): 9781489986443
Издательство: Springer
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Цена: 174130.00 T
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Описание: This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications.

Автор: Boye Schnack Nielsen
Название: In Situ Hybridization Protocols
ISBN: 1493955268 ISBN-13(EAN): 9781493955268
Издательство: Springer
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Цена: 93160.00 T
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Описание: In Situ Hybridization Protocols, Fourth Edition contains 21 protocols that utilize the in situ hybridization technology to document or take advantage of the visualization of specific RNA molecules.