Risk Assessment in Chemical Carcinogenesis, Gotthard Schettler; Dietrich Schm?hl; Thomas Klenn

Автор: R. Colin Garner; Jan Hradec
Название: Biochemistry of Chemical Carcinogenesis
ISBN: 1461278562 ISBN-13(EAN): 9781461278566
Издательство: Springer
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Описание: The hepatocarcinogenicity of aflatoxin BI in rats, ducks and rainbow trout has been convincingly demonstrated (1). In contrast, adult mice appear to be resistant to the toxic and carcinogenic effects. Newborn and infant mice are more sensitive to the effects of different hepatocarcinogens (2,3) and also to AFB, which induced hepatomas in newborn C57BL/6 x C3H FI I mice (4). A singl dose model of aflatoxin hepatocarcinogenesis was tested in infant C57BL/6 mice. AFBI was administered i.p. on day 7 after birth and the following data were investigated: 1) Changes in the activities of microsomal cytochrome P-450 dependant enzymes and conjugating enzymes in the course of the 20-month-Iong aflatoxin hepa- tocarcinogenesis study. At intervals of 6,8,12,18 and 20 months a ter AFBI administration, the concentrations of cyt P-450 andb and the acti- 5 vities of NADPH-, NADH-cyt c reductase, AOH, ADM, EH and GST were deter- mined. 2) Effect of continually administered diethyldithiocarbamate on the course of aflatoxin carcinogenesis. MATERIALS AND METHODS Aflatoxin BI was prepared biosynthetically in our laboratory and was checked for purity chromatographically, spectrophotometrically and by NMR.

Автор: Erich Hecker; H. Zur Hausen; E.G. Jung; F. Marks;
Название: Skin Carcinogenesis in Man and in Experimental Models
ISBN: 3642848834 ISBN-13(EAN): 9783642848834
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Автор: Frederick F. Becker
Название: Etiology: Chemical and Physical Carcinogenesis
ISBN: 1461566002 ISBN-13(EAN): 9781461566007
Издательство: Springer
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Описание: Although great strides have been made toward those goals, as evidenced by a number of new chapters and the new information gathered into others, and although the achievement of those goals sometimes appears but a tantalizing experiment away, none have been achieved.

Автор: Trevor M. Penning
Название: Chemical Carcinogenesis
ISBN: 1617797294 ISBN-13(EAN): 9781617797293
Издательство: Springer
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Описание: Presenting the current advances in chemical carcinogenesis, this volume promotes the view that the chemical alteration of DNA is a route cause of many cancers. Topics include the multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action.

Автор: F.A. Beland; L.G. Cain; J.S. Felton; J.D. Groopman
Название: Chemical Carcinogenesis and Mutagenesis I
ISBN: 3642747779 ISBN-13(EAN): 9783642747779
Издательство: Springer
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Описание: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin- Madison.

Автор: C.F. Arlett; Colin S. Cooper; Philip L. Grover; D.
Название: Chemical Carcinogenesis and Mutagenesis II
ISBN: 3642747809 ISBN-13(EAN): 9783642747809
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Описание: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin- Madison.

Автор: Yusaku Tagashira
Название: P-450 and Chemical Carcinogenesis
ISBN: 1468450328 ISBN-13(EAN): 9781468450323
Издательство: Springer
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Описание: This book is one of a GANN Monograph on Cancer Research series and is based on a Japanese Cancer Association-sponsored symposium entitled "Multiplicity of Chemical Carcinogen-Activating Enzymes* with Particular Emphasis on Cytochrome P-450" which was held in Tokyo on November 21, 1983.

Автор: H.K. M?ller-Hermelink; H.G. Neumann; W. Dekant
Название: Risk and Progression Factors in Carcinogenesis
ISBN: 364264385X ISBN-13(EAN): 9783642643859
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Описание: Cellular transformation and carcinogenesis are considered a multistep process starting with DNA lesions and progressing through loss of cellular growth control and increase invasive and metastatic properties.

Автор: Oscar Sudilovsky; Henry C. Pitot; L.A. Liotta
Название: Boundaries between Promotion and Progression during Carcinogenesis
ISBN: 1468459961 ISBN-13(EAN): 9781468459968
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Описание: Based on a conference held in Cleveland, Ohio, September 28--30, 1988

Автор: A. Schimpl; Peter Bannasch
Название: The Cytoplasm of Hepatocytes during Carcinogenesis
ISBN: 3642884016 ISBN-13(EAN): 9783642884016
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Описание: Used in the proper dose, these carcinogens lead within a few months to the formation of multicentric hepatomas in practically 100 Ufo of the experimental animals, and are therefore a very useful tool for studies of the cytogenesis of cancer (see BUCHNER, 1961;

Автор: P. H?hn; E. Grundmann; E. Kunze; K. Nomura; C. Wit
Название: Carcinogenesis
ISBN: 3642672949 ISBN-13(EAN): 9783642672941
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Описание: Concepts on the Causal Genesis of Human Intestinal Tumors The action of chemical substances has a significant role in the genesis of human tumors. It is assumed that most human tumors are induced by exogenous chemical noxae (Schmahl, 1970;Heidelberger, 1975;

Автор: Max Costa
Название: Metal Carcinogenesis Testing
ISBN: 148994091X ISBN-13(EAN): 9781489940919
Издательство: Springer
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Описание: Metal Carcinogenesis Testing explains fundamental principles of metal carcinogenesis as they are currently understood, and provides detailed practical descriptions of rapid and inexpensive in vitro assay methodology presently in use for the detection of potentially carci- nogenic metals and their compounds.