Manual for the Planning and Implementation of Therapeutic Studies, S. Biefang; W. K?pcke; M.A. Schreiber

Автор: R.J. Does; C.B. Roes; A. Trip
Название: Statistical Process Control in Industry
ISBN: 0792355709 ISBN-13(EAN): 9780792355700
Издательство: Springer
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Цена: 130390.00 T
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Описание: One of the central elements of Total Quality Management is Statistical Process Control, more commonly known as SPC. This book describes the pitfalls and traps which businesses encounter when implementing and assuring SPC. Illustrations are given from practical experience in various companies.

Название: Analysis of contingency tables
ISBN: 0817648100 ISBN-13(EAN): 9780817648107
Издательство: Springer
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Цена: 79190.00 T
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Описание: Characterized by the diversity of their applications, contingency tables play a key role in fields such as education and the social sciences. This volume presents a variety of new and sophisticated models for analyzing two- and multidimensional tables.

Автор: Gagniuc, Paul A.,
Название: Markov Chains: From Theory to Implementation and E xperimentation
ISBN: 1119387558 ISBN-13(EAN): 9781119387558
Издательство: Wiley
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Цена: 109770.00 T
Наличие на складе: Нет в наличии.
Описание: A fascinating and instructive guide to Markov chains for experienced users and newcomers alike This unique guide to Markov chains approaches the subject along the four convergent lines of mathematics, implementation, simulation, and experimentation.

Автор: Giovanni Peccati; Murad Taqqu
Название: Wiener Chaos: Moments, Cumulants and Diagrams
ISBN: 8847056047 ISBN-13(EAN): 9788847056046
Издательство: Springer
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Цена: 93160.00 T
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Описание: The concept of Wiener chaos generalizes to an infinite-dimensional setting the properties of orthogonal polynomials associated with probability distributions on the real line.This book is concerned with combinatorial structures arising from the studyof chaotic random variables related to infinitely divisible random measures.

Автор: Robert
Название: The bayesian choice
ISBN: 0387715983 ISBN-13(EAN): 9780387715988
Издательство: Springer
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Цена: 60550.00 T
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Описание: This is an introduction to Bayesian statistics and decision theory, including advanced topics such as Monte Carlo methods. This new edition contains several revised chapters and a new chapter on model choice.

Автор: Maria Kateri
Название: Contingency Table Analysis
ISBN: 1493939599 ISBN-13(EAN): 9781493939596
Издательство: Springer
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Цена: 55890.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Characterized by the diversity of their applications, contingency tables play a key role in fields such as education and the social sciences. This volume presents a variety of new and sophisticated models for analyzing two- and multidimensional tables.

Автор: Weili He; Jos? Pinheiro; Olga M. Kuznetsova
Название: Practical Considerations for Adaptive Trial Design and Implementation
ISBN: 149395539X ISBN-13(EAN): 9781493955398
Издательство: Springer
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Цена: 158380.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive trials in saving costs and time, ultimately getting drugs to patients sooner, their adoption in clinical development is still relatively low. One of the chief reasons is the higher complexity of adaptive design trials as compared to traditional trials. Barriers to the use of clinical trials with adaptive features include the concerns about the integrity of study design and conduct, the risk of regulatory non-acceptance, the need for an advanced infrastructure for complex randomization and clinical supply scenarios, change management for process and behavior modifications, extensive resource requirements for the planning and design of adaptive trials and the potential to relegate key decision makings to outside entities. There have been limited publications that address these practical considerations and recommend best practices and solutions. This book fills this publication gap, providing guidance on practical considerations for adaptive trial design and implementation. The book comprises three parts: Part I focuses on practical considerations from a design perspective, whereas Part II delineates practical considerations related to the implementation of adaptive trials. Putting it all together, Part III presents four illustrative case studies ranging from description and discussion of specific adaptive trial design considerations to the logistic and regulatory issues faced in trial implementation. Bringing together the expertise of leading key opinion leaders from pharmaceutical industry, academia, and regulatory agencies, this book provides a balanced and comprehensive coverage of practical considerations for adaptive trial design and implementation.

Автор: Weili He; Jos? Pinheiro; Olga M. Kuznetsova
Название: Practical Considerations for Adaptive Trial Design and Implementation
ISBN: 149391099X ISBN-13(EAN): 9781493910991
Издательство: Springer
Рейтинг:
Цена: 158380.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive trials in saving costs and time, ultimately getting drugs to patients sooner, their adoption in clinical development is still relatively low. One of the chief reasons is the higher complexity of adaptive design trials as compared to traditional trials. Barriers to the use of clinical trials with adaptive features include the concerns about the integrity of study design and conduct, the risk of regulatory non-acceptance, the need for an advanced infrastructure for complex randomization and clinical supply scenarios, change management for process and behavior modifications, extensive resource requirements for the planning and design of adaptive trials and the potential to relegate key decision makings to outside entities. There have been limited publications that address these practical considerations and recommend best practices and solutions. This book fills this publication gap, providing guidance on practical considerations for adaptive trial design and implementation. The book comprises three parts: Part I focuses on practical considerations from a design perspective, whereas Part II delineates practical considerations related to the implementation of adaptive trials. Putting it all together, Part III presents four illustrative case studies ranging from description and discussion of specific adaptive trial design considerations to the logistic and regulatory issues faced in trial implementation. Bringing together the expertise of leading key opinion leaders from pharmaceutical industry, academia, and regulatory agencies, this book provides a balanced and comprehensive coverage of practical considerations for adaptive trial design and implementation.

Автор: R.J. Does; C.B. Roes; A. Trip
Название: Statistical Process Control in Industry
ISBN: 9048151708 ISBN-13(EAN): 9789048151707
Издательство: Springer
Рейтинг:
Цена: 130390.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It will also appeal to specialists in engineering and management, for example in the electronic industry, discrete parts industry, process industry, automotive and aircraft industry and food industry.

Автор: Wolfgang H?rdle
Название: Smoothing Techniques
ISBN: 1461287685 ISBN-13(EAN): 9781461287681
Издательство: Springer
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Цена: 130430.00 T
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Описание: A principal feature of smoothing, the averaging of data points in a prescribed neighborhood, is not really practicable in dimensions greater than three if we have just one hundred data points.

Автор: Coelho, Jo?o Paulo | Pin
Название: Hidden Markov Models
ISBN: 0367203499 ISBN-13(EAN): 9780367203498
Издательство: Taylor&Francis
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Цена: 163330.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It presents analysis of both continuous and discrete Markov chains. It deals with concepts in a generic way, most books on Hidden Markov Models focus on speech processing applications. It presents the translation of Hidden Markov Models concepts from the realm of formal mathematics into computer codes using a high-level language.

Автор: William E. Schiesser
Название: PDE Models for Atherosclerosis Computer Implementation in R
ISBN: 1681734451 ISBN-13(EAN): 9781681734453
Издательство: Mare Nostrum (Eurospan)
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Цена: 82230.00 T
Наличие на складе: Невозможна поставка.
Описание: Atherosclerosis is a pathological condition of the arteries in which plaque buildup and stiffening (hardening) can lead to stroke, myocardial infarction (heart attacks), and even death. Cholesterol in the blood is a key marker for atherosclerosis, with two forms: (1) LDL - low density lipoproteins and (2) HDL - high density lipoproteins. Low LDL and high HDL concentrations are generally considered essential for limited atherosclerosis and good health.This book pertains to a mathematical model for the spatiotemporal distribution of LDL and HDL in the arterial endothelial inner layer (EIL, intima). The model consists of a system of six partial differential equations (PDEs) with the dependent variables1. concentration of modified LDL2. ℎ concentration of HDL3. concentration of chemoattractants4. concentration of ES cytokines5. density of monocytes/macrophages6. density of foam cells and independent variables1. distance from the inner arterial wall2. timeThe focus of this book is a discussion of the methodology for placing the model on modest computers for study of the numerical solutions. The foam cell density as a function of the bloodstream LDL and HDL concentrations is of particular interest as a precursor for arterial plaque formation and stiffening.The numerical algorithm for the solution of the model PDEs is the method of lines (MOL), a general procedure for the computer-based numerical solution of PDEs. The MOL coding (programming) is in R, a quality, open-source scientific computing system that is readily available from the Internet. The R routines for the PDE model are discussed in detail, and are available from a download link so that the reader/analyst/researcher can execute the model to duplicate the solutions reported in the book, then experiment with the model, for example, by changing the parameters (constants) and extending the model with additional equations.