Enzyme Technology, Ashok Pandey; Colin Webb; Carlos Ricardo Soccol; C

Автор: Dwevedi
Название: Enzyme Immobilization
ISBN: 331941416X ISBN-13(EAN): 9783319414164
Издательство: Springer
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Цена: 130430.00 T
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Описание: This book covers the latest developments in enzyme immobilization with its wide applications, such as for industry, agriculture, medicine, and the environment. Topics covered include basics of enzyme immobilization, its implication in therapeutics and disease diagnostics, and its significance in solving environmental problems. This is an ideal book for researchers, graduate and postgraduate students, as well as scientists in industry, agriculture and health sectors. This book is a complete summary of enzyme immobilization and also thoroughly covers all the latest research.

Автор: Jeffrey W. Kelly; Thomas O. Baldwin
Название: Applications of Enzyme Biotechnology
ISBN: 1475792379 ISBN-13(EAN): 9781475792379
Издательство: Springer
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Цена: 174150.00 T
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Описание: Proceedings of the Texas A&M University IUCCP Ninth Annual Symposium held in College Station, Texas, March 18-21, 1991.

Автор: Maddela
Название: Soil Enzymes. Influence of Sugar Industry Effluents on Soil Enzyme Activities
ISBN: 3319426540 ISBN-13(EAN): 9783319426549
Издательство: Springer
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Цена: 51230.00 T
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Описание: This book addresses issues arising from discharge of effluents from sugar industry on to surrounding land or into a water body such as physicochemical properties of soil, changes in the micro flora, quantification of soil enzyme activities as influenced by effluents. Disposal of effluents without neutralization has become general practice. These effluents are chemically heterogeneous, contain organic and inorganic pollutants including, sugar baggage, molasses, carbonates, bicarbonates. The impact of sugar industry effluents on microbial activities in terrestrial ecosystem is scanty. There is also significant interest in the study of soil enzymes because such effect reflects the potential capacity of a soil to perform certain biological transformation of soil fertility.

Автор: Ashok Pandey; Colin Webb; Carlos Ricardo Soccol; C
Название: Enzyme Technology
ISBN: 1441921249 ISBN-13(EAN): 9781441921246
Издательство: Springer
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Цена: 174130.00 T
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Описание: This book is a unique resource for state-of-the-art research findings on biotechnological enzyme innovations. It provides a great deal of information on the potential of enzymes for commercial exploitation. The book includes photographs, figures, and tables.

Название: Enzyme kinetics in drug metabolism
ISBN: 1627037578 ISBN-13(EAN): 9781627037570
Издательство: Springer
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Цена: 204970.00 T
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Описание:

1. Enzyme Kinetics in Drug Metabolism - Fundamentals and Applications

Swati Nagar, Upendra A. Argikar, and Donald J. Tweedie

Part I. Fundamentals of Enzyme Kinetics

2. Fundaments of Enzyme Kinetics

Eleanore Seibert and Timothy S. Tracy

3. Different Enzyme Kinetic Models

Eleanore Seibert and Timothy S. Tracy

4. Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance

Barbara Ring, Steven A. Wrighton, and Michael Mohutsky

5. Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions

Michael Mohutsky and Stephen D. Hall

6. Multi-Enzyme Kinetics and Sequential Metabolism

Larry C. Wienkers and Brooke VandenBrink

7. Consideration of the Unbound Drug Concentration in Enzyme Kinetics

Nigel J. Waters, R. Scott Obach, and Li Di

Part II. Kinetics of Drug Metabolizing Enzymes and Transporters

8. Enzyme Kinetics of Oxidative Metabolism - Cytochromes P450

Ken Korzekwa

9. Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase

John T. Barr, Kanika Choughule, and Jeffrey P. Jones

10. Enzyme Kinetics of Conjugative Enzymes - PAPS

Margaret O. James

11. Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)

Jin Zhou and John Miners

12. Principles and Experimental Considerations for in vitro Transporter Interaction Assays

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Wiskercher, and Ismael J. Hidalgo

Part III. Modeling Considerations

13. Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data - from in vitro Tools to Mechanistic Modeling

Aleksandra Galetin

14. The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers

Joseph Bentz and Harma Ellens

15. Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism

Nnena A. Finn and Melissa L. Kemp

Part IV. Variability in Kinetics

16. Variability in Human in vitro Enzyme Kinetics

Ying-Hong Wang and Christopher R. Gibson

17. Sources of Interindividual Variability

Yvonne Lin and Kenneth E. Thummel

Part V. Case Studies

18. Case Study 1. Practical Considerations with Experimental Design and Interpretation

John T. Barr, Darcy R. Flora, and Otito Iwuchukwu

19. Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies

Upendra A. Argikar and Swati Nagar

20. Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies - Real Life Examples

Yongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy, and Donald J. Tweedie

21. Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast

Ken Korzekwa

22. Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development

Ian Templeton, Gary Eichenbaum, Rucha Sane, and Jin Zhou

23. Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Weiskircher, and Ismael J. Hidalgo

24. Case Study 7. Compiled Aha Moments in Enzyme Kine

Автор: Daniel L. Purich
Название: Enzyme Kinetics and Mechanism, Part F: Detection and Characteriza
ISBN: 0121822575 ISBN-13(EAN): 9780121822576
Издательство: Elsevier Science
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Цена: 167030.00 T
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Описание: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with mo than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Автор: Helmut Sies
Название: Protein Sensors and Reactive Oxygen Species, Part B: Thiol Enzyme
ISBN: 0121822516 ISBN-13(EAN): 9780121822514
Издательство: Elsevier Science
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Цена: 167030.00 T
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Описание: This volume of Methods in Enzymology is a companion to Volume 347 and addresses direct sensing of reactive oxygen species and related free radicals by thiol enzymes and proteins.

Автор: Colin Suckling
Название: Enzyme Chemistry
ISBN: 9401073171 ISBN-13(EAN): 9789401073172
Издательство: Springer
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Цена: 139310.00 T
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Описание: As the first edition of this book was going through the publication process, a revolution was taking place in the technologies available for the study of enzymes. The second edition of `Enzyme Chemistry, Impact and Applications` takes on board these new develop- ments whilst maintaining the overall aims and views of the first edition.

Автор: Judith Klinman; Sharon Hammes- Schiffer
Название: Dynamics in Enzyme Catalysis
ISBN: 3642389619 ISBN-13(EAN): 9783642389610
Издательство: Springer
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Цена: 260870.00 T
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Описание: Cindy Schulenburg and Donald Hilvert, Protein Conformational Disorder and Enzyme Catalysis. Brooks III, Multiple Intermediates, Diverse Conformations, and Cooperative Conformational Changes Underlie the Catalytic Hydride Transfer Reaction of Dihydrofolate Reductase.

Автор: A. Cooper
Название: The Enzyme Catalysis Process
ISBN: 1475716095 ISBN-13(EAN): 9781475716092
Издательство: Springer
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Цена: 113190.00 T
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Автор: Antonio Baici
Название: Kinetics of Enzyme-Modifier Interactions
ISBN: 3709114012 ISBN-13(EAN): 9783709114018
Издательство: Springer
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Цена: 149060.00 T
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Описание: The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism.

Автор: Young Je Yoo; Yan Feng; Yong-Hwan Kim; Camila Flor
Название: Fundamentals of Enzyme Engineering
ISBN: 9402410244 ISBN-13(EAN): 9789402410242
Издательство: Springer
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Цена: 111790.00 T
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