Mouse Models in the Study of Genetic Neurological Disorders, Brian Popko

Автор: Brian Popko
Название: Mouse Models in the Study of Genetic Neurological Disorders
ISBN: 1461372178 ISBN-13(EAN): 9781461372172
Издательство: Springer
Рейтинг:
Цена: 113190.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The number of mouse models that are available for the study of human genetic neurological disorders is large and growing rapidly.

Автор: Basabdatta Sen Bhattacharya; Fahmida N. Chowdhury
Название: Validating Neuro-Computational Models of Neurological and Psychiatric Disorders
ISBN: 3319200364 ISBN-13(EAN): 9783319200361
Издательство: Springer
Рейтинг:
Цена: 130430.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is a collection of articles by leading researchers working at the cutting edge of neuro-computational modelling of neurological and psychiatric disorders. Each article contains model validation techniques used in the context of the specific problem being studied. Validation is essential for neuro-inspired computational models to become useful tools in the understanding and treatment of disease conditions. Currently, the immense diversity in neuro-computational modelling approaches for investigating brain diseases has created the need for a structured and coordinated approach to benchmark and standardise validation methods and techniques in this field of research. This book serves as a step towards a systematic approach to validation of neuro-computational models used for studying brain diseases and should be useful for all neuro-computational modellers.

Автор: Basabdatta Sen Bhattacharya; Fahmida N. Chowdhury
Название: Validating Neuro-Computational Models of Neurological and Psychiatric Disorders
ISBN: 3319371363 ISBN-13(EAN): 9783319371368
Издательство: Springer
Рейтинг:
Цена: 113180.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book serves as a step towards a systematic approach to validation of neuro-computational models used for studying brain diseases and should be useful for all neuro-computational modellers.

Автор: A.J. Nonneman; M.L. Woodruff
Название: Toxin-Induced Models of Neurological Disorders
ISBN: 1489914498 ISBN-13(EAN): 9781489914491
Издательство: Springer
Рейтинг:
Цена: 93160.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Tbis volume discusses and evaluates the use of neurotoxins to produce animal models of human neurodegenerative diseases.

Автор: Van Bockstaele
Название: Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders
ISBN: 1461479398 ISBN-13(EAN): 9781461479390
Издательство: Springer
Рейтинг:
Цена: 174150.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book offers current information on advances in the field of endocannabinoid signaling and potential therapeutic applications with a particular emphasis on monoaminergic circuits.

Автор: Farooqui
Название: Phytochemicals, Signal Transduction, and Neurological Disorders
ISBN: 1489991069 ISBN-13(EAN): 9781489991065
Издательство: Springer
Рейтинг:
Цена: 174130.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Phytochemicals Signal Transduction and Neurological DisordersPhytochemicals are heterogeneous group of bioactive compounds produced by plants, which are extensively researched by scientists for their health-promoting potentials in human diseases.

Автор: Farooqui, Tahira
Название: Trace Amines and Neurological Disorders
ISBN: 0128036036 ISBN-13(EAN): 9780128036037
Издательство: Elsevier Science
Рейтинг:
Цена: 116780.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders.

Автор: E. Antonio Chiocca; Xandra O. Breakefield
Название: Gene Therapy for Neurological Disorders and Brain Tumors
ISBN: 1475753144 ISBN-13(EAN): 9781475753141
Издательство: Springer
Рейтинг:
Цена: 174150.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology.

Автор: James R. Connor
Название: Metals and Oxidative Damage in Neurological Disorders
ISBN: 148990199X ISBN-13(EAN): 9781489901996
Издательство: Springer
Рейтинг:
Цена: 174150.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The purpose of this book is to bring together scientists and clinicians interested in oxidative injury in the nervous system but whose approaches to investigation and treatment design vary widely. The third section contains the clinicaI diseases in which oxidative injury is known to contribute to the pathogenic process.

Автор: Akhlaq A. Farooqui
Название: Inflammation and Oxidative Stress in Neurological Disorders
ISBN: 331904110X ISBN-13(EAN): 9783319041100
Издательство: Springer
Рейтинг:
Цена: 158380.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents readers with cutting edge and comprehensive information on the effect of diet, exercise and sleep on neuroinflammation and oxidative stress in normal brains and brains from patients with neurological disorders.

Автор: Raphael Pinaud; Liisa A. Tremere
Название: Immediate Early Genes in Sensory Processing, Cognitive Performance and Neurological Disorders
ISBN: 1489987436 ISBN-13(EAN): 9781489987433
Издательство: Springer
Рейтинг:
Цена: 148010.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a compilation of the most up-to-date literature on the topic of immediate early genes (IEGs). It reviews and details experiments and theories that challenge the reader to expand their view on how IEG research is currently being used to advance our understanding of static and active brain circuits.

Автор: Xuenong Bo; Joost Verhaagen
Название: Gene Delivery and Therapy for Neurological Disorders
ISBN: 1493923056 ISBN-13(EAN): 9781493923052
Издательство: Springer
Рейтинг:
Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors` laboratories.