G Protein Signaling Mechanisms in the Retina, Kirill A. Martemyanov; Alapakkam P. Sampath

Автор: Reto Weiler; Neville N. Osborne
Название: Neurobiology of the Inner Retina
ISBN: 3642741517 ISBN-13(EAN): 9783642741517
Издательство: Springer
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Описание: Proceedings of the NATO Advanced Research Workshop on the Neurobiology of the Inner Retina held in Oldenburg, FRG, from August 8-12, 1988

Автор: Catherine Bowes Rickman; Matthew M. LaVail; Robert
Название: Retinal Degenerative Diseases
ISBN: 3319371525 ISBN-13(EAN): 9783319371528
Издательство: Springer
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Описание:

Part I Age-Related Macular Degeneration (AMD).- Apolipoprotein E Isoforms and AMD.- Role of Chemokines in Shaping Macrophage Activity in AMD.- Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD).- Gene Structure of the 10q26 locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?.- Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration.- Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration.- A Brief Discussion on Lipid Activated Nuclear Receptors and Their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD).- Extracellular Matrix Alterations and Deposit Formation in AMD.- The NLRP3 Inflammasome and its Role in Age-related Macular Degeneration.- Oxidative Stress and the Nrf2 Anti-Oxidant Transcription Factor in Age-Related Macular Degeneration.- Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease.- VEGF-A and the NLRP3 Inflammasome in Age-Related Macular Degeneration.- Interrelation Between Oxidative Stress and Complement Activation in Models of Age-Related Macular Degeneration.- Gene-diet Interactions in Age-Related Macular Degeneration.- Challenges in the Development of Therapy for Dry Age-Related Macular Degeneration.- Nanoceria: A Potential Therapeutic for Dry AMD.- β-amyloidopathy in the Pathogenesis of Age-Related Macular Degeneration in Correlation with Neurodegenerative Diseases.- Part II Macular Dystrophies/Inherited Macular Degeneration.- Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans.- Mouse Models of Stargardt 3 Dominant Macular Degeneration.- Current Progress in Deciphering Importance of VLC-PUFA in the Retina.- Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy: Similarities to Age-related Macular Degeneration and Potential Therapies.- Part III Inherited Retinal Degenerations.- Hsp90 as a Potential Therapeutic Target in Retinal Disease.- Leber Congenital Amaurosis: Genotypes and Retinal Structure Phenotypes.- A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.- Ablation of Chop Transiently Enhances Photoreceptor Survival But Does Not Prevent Retinal Degeneration in Transgenic Mice Expressing Human P23H Rhodopsin.- Identification of a Novel Gene on 10q22 Causing Autosomal Dominant Retinitis Pigmentosa (adRP).- FAM161A and TTC8 Are Differentially Expressed in Non-allelelic Early Onset Retinal Degeneration.- Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization.- RDS Functional Domains and Dysfunction in Disease.- TULP1 Missense Mutations Induces the Endoplasmic Reticulum Unfolded Protein Response Stress Complex (ER-UPR).- Understanding Cone Photoreceptor Cell Death in Achromatopsia.- Geranylgeranylacetone Suppresses N-methyl-N-nitrosourea-induced Photoreceptor Cell Loss in Mice.- My Retina Tracker(TM) An On-line International Registry for People Affected with Inherited Orphan Retinal Degenerative Diseases and their Genetic Relatives - A New Resource.- A Mini-Review: Animal Models of GUCY2D Leber Congenital Amaurosis (LCA1).- A Comprehensive Review of Mutations in the MERTK Proto-oncogene.- Part IV In Vivo Imaging and Other Diagnostic Advances.- New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo.- Reliability and repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia.- Quantitative Autofluorescence in Best Vitelliform Macular Dystrophy: RPE Lipofuscin is Not Increased in Non-Lesion Areas of Retina.- Interpretation of Flood-Illuminated Adaptive Optics Images in Subjects with Retinitis Pigmentosa.- Intra-familial Similarity of Wide-Field Fundus Autofluorescence in Inherited
Retinal Dystrophy.- Wide-Field Fundus Autofluorescence for Retinitis Pigmentosa

Автор: Joyce Tombran-Tink; Colin J. Barnstable
Название: Retinal Degenerations
ISBN: 1493960989 ISBN-13(EAN): 9781493960989
Издательство: Springer
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Описание: For centuries, humans have tried to explain the complex process of vision and find effective treatments for eye diseases. Perhaps the oldest surviving record of ancient ophthalmic practices is the Babylonian code of Hammurabi that over 4000 years ago, mentioned fees for eye surgery—and penalties for unsuccessful operations that led to loss of the eye. Babylonian medicine was controlled by priests who directed the work of skilled surgeons. The earliest records of Egyptian medicine date from almost the same time. The Ebers Papyrus, dating back to more than 3500 years ago is a superbly preserved document in which a section outlines a relatively advanced system of diagnosis and treatment of various ocular pathologies. The text reveals that ancient Greek and Egyptian physicians prescribed “liver juice” for night blindness. This was obtained from roasted and crushed ox liver. We now know that their prescription contained a remarkable amount of vitamin A. It was only within the last century, however, that we have recognized the importance of vitamin A to the function of photoreceptors and visual acuity and that its deficiency can result in night blindness. Egyptian ophthalmological practices were held in high esteem in the ancient world and so were their medical institutes, called “peri-ankh,” which existed since the first dynasty. Herodotus, the fifth century BC Greek historian, comments on the specialization of the physicians: “Each physician treats just one disease.

Автор: Hans-Joachim Wagner
Название: Cell Types and Connectivity Patterns in Mosaic Retinas
ISBN: 3540090134 ISBN-13(EAN): 9783540090137
Издательство: Springer
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Цена: 121110.00 T
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Описание: In many parts of vertebrate and invertebrate central nervous systems, groups of nerve or receptor cells can be found that are arranged and connected according to a precise, functionally defined pattern (Braitenberg, 1973;

Автор: Kirill A. Martemyanov; Alapakkam P. Sampath
Название: G Protein Signaling Mechanisms in the Retina
ISBN: 1493912178 ISBN-13(EAN): 9781493912179
Издательство: Springer
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Цена: 130610.00 T
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Описание: The main purpose of this volume is to provide a focused analysis of the function of the G protein-coupled signaling pathways that operate in the interconnected network of retinal neurons as they detect and encode the information carried by light.

Автор: Barbara L. Finlay; Dale R. Sengelaub
Название: Development of the Vertebrate Retina
ISBN: 146845594X ISBN-13(EAN): 9781468455946
Издательство: Springer
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Цена: 113190.00 T
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Описание: Its accessibility, readily identifiable neuronal types, and specialized neuronal connectivity and morphology have made it a model system for researchers interested in the general questions of the genet- ic, molecular, and developmental control of cell type and shape.

Автор: M.B. Djamgoz; S. Archer; S. Vallerga
Название: Neurobiology and Clinical Aspects of the Outer Retina
ISBN: 9401042373 ISBN-13(EAN): 9789401042376
Издательство: Springer
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Цена: 139310.00 T
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Описание: Thus the basic neurobiology of the outer retina is related to the visual process, and visual defects that could arise from abnormalities in this part of the retina are highlighted in the first 16 chapters.

Автор: Andreas Reichenbach; Andreas Bringmann
Название: M?ller Cells in the Healthy and Diseased Retina
ISBN: 1489985026 ISBN-13(EAN): 9781489985026
Издательство: Springer
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Описание: Muller glial cells ensheath all retinal neurons in vertebrate retinae. There are a multitude of functional interactions between neurons and Muller cells, including delivery of the light stimuli to the photoreceptor cells in the inverted vertebrate retina, a `metabolic symbiosis` with the neurons, and the processing of visual information. Muller cells are also responsible for the maintenance of the homeostasis of the retinal extracellular milieu (ions, water, neurotransmitter molecules, and pH). In vascularized retinae, Muller cells may also be involved in the control of angiogenesis, and the regulation of retinal blood flow. Virtually every disease of the retina is associated with a reactive Muller cell gliosis which, on the one hand, supports the survival of retinal neurons but, on the other hand, may accelerate the progress of neuronal degeneration:

Автор: Gianluca Tosini; P. Michael Iuvone; Douglas G. McM
Название: The Retina and Circadian Rhythms
ISBN: 1493946641 ISBN-13(EAN): 9781493946648
Издательство: Springer
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Цена: 130590.00 T
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Описание: 1. Introduction.- 2. Fundamental Retinal Circuitry for Circadian Rhythms.- 3. Circadian photoreception: from phototransduction to behaviour.- 4. Role of Melatonin and Dopamine in the Regulation of Retinal Circadian Rhythms.- 5. Circadian Organization of the Vertebrate Retina.- 6. Rhythmicity of the Retinal Pigment Epithelium.- 7. Retinal Circadian Rhythms in Mammals Revealed Using Electroretinography.- 8. Circadian Clock and Light Induced Retinal Damage.- 9. Circadian Rhythms and Vision in Zebrafish.- 10. Circadian Modulation of the Limulus Eye for Day and Night Vision.- 11. Molluscan Ocular Pacemakers: Lessons Learned.

Автор: M. Vogel
Название: Postnatal Development of the Cat`s Retina
ISBN: 3540087990 ISBN-13(EAN): 9783540087991
Издательство: Springer
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Описание: Furthermore, Babuchin had already indicated that the structural development in the area of the posterior pole is very rapid compared with those regions of the retina which are situated more peripherally.

Автор: Wolf Krebs; Ingeborg Krebs
Название: Primate Retina and Choroid
ISBN: 1461390974 ISBN-13(EAN): 9781461390978
Издательство: Springer
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Цена: 97820.00 T
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Описание: . . . . . . . . . 30 Outer Plexiform Layer and Horizontal Cells .................. . . . . . . . . 142 Cells of Choroidal Connective Tissue ....................... . . . A scholarly review of the whole spectrum of research on the re tina and choroid is not feasible in a single volume.

Автор: Robert E. Anderson; Joe G. Hollyfield; Matthew M.
Название: Degenerative Diseases of the Retina
ISBN: 1461357748 ISBN-13(EAN): 9781461357742
Издательство: Springer
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Описание: In 1984, we organized a two-day symposium on retinal degenerations as part of the biennial meeting of the VI International Society for Eye Research, held in Alicante, Spain.