Recombinant Gene Expression, Argelia Lorence

Автор: Rodrick Wallace; Deborah Wallace
Название: Gene Expression and Its Discontents
ISBN: 3319480774 ISBN-13(EAN): 9783319480770
Издательство: Springer
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Цена: 144410.00 T
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Описание: This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer’s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.

Автор: W.N. Drohan; Leon W. Hoyer
Название: Recombinant Technology in Hemostasis and Thrombosis
ISBN: 1461366445 ISBN-13(EAN): 9781461366447
Издательство: Springer
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Цена: 46570.00 T
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Описание: The speakers described the essential features of the genes responsible for key plasma proteins important in hemostasis, including procoagulant Factors VIII and IX and anticoagulant proteins, Antithrombin III and Protein C.

Автор: Lorraine O`Driscoll
Название: Gene Expression Profiling
ISBN: 149396173X ISBN-13(EAN): 9781493961733
Издательство: Springer
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Цена: 111790.00 T
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Описание: In this book, experts present a broad range of available and developing techniques for the analysis of gene expression at the DNA, RNA, and protein levels. A collection of clearly described and illustrated chapters includes tips and implementation advice.

Автор: Thomas C. Evans, Jr.; Ming-Qun Xu
Название: Heterologous Gene Expression in E.coli
ISBN: 1493957252 ISBN-13(EAN): 9781493957255
Издательство: Springer
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Цена: 135090.00 T
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Описание: Practical and cutting-edge, Heterologous Gene Expression in E. coli: Methods and Protocols seeks to familiarize the researcher with the myriad of E. coli expression strains available and move E. coli closer to that ideal of the perfect host.

Автор: Gary H. Perdew; Jack P. Vanden Heuvel; Jeffrey M.
Название: Regulation of Gene Expression
ISBN: 1627038086 ISBN-13(EAN): 9781627038089
Издательство: Springer
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Цена: 139750.00 T
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Описание: The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http://moltox. cas. psu. edu and select “Courses. ” The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.

Автор: Yaron Shav-Tal
Название: Imaging Gene Expression
ISBN: 1493963120 ISBN-13(EAN): 9781493963126
Издательство: Springer
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Цена: 102480.00 T
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Описание: This book will help researchers working towards imaging in the context of complete organisms. It features readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.

Автор: Edward J. Murray
Название: Gene Transfer and Expression Protocols
ISBN: 1489944036 ISBN-13(EAN): 9781489944030
Издательство: Springer
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Цена: 111790.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Biology is the study of living things. The classical approach might be described as holistic and descriptive, whereas the modern molecular - proach aims to be investigative, reductionist, and mechanistic . Genes contain all the information for the structure of all living things ; thus, the understanding of how genes are regulated is an important step toward understanding the nature of living things. The study of gene regulation has been made more tractable by the design of simple expe- mental models in which a single gene can be isolated from the milieu of the organism. The new science of molecular biology has introduced techniques that permit the design of such experimental models. In - sence, the genome of the organism is dissected in such a manner that specific genes may now be introduced into an appropriate cell line . Subsequent analysis of the proteins expressed from the genes under study results in the identification of the regulatory DNA sequences .

Автор: John F. Atkins; Raymond F. Gesteland
Название: Recoding: Expansion of Decoding Rules Enriches Gene Expression
ISBN: 146142531X ISBN-13(EAN): 9781461425311
Издательство: Springer
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Цена: 191550.00 T
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Описание: Knowledge of recoding is essential for understanding the organization and expression of genes in viruses and all organisms. This volume details specific recoding examples to assist the reader with understanding the mechanisms and the mRNA signals.

Автор: Spyros Papageorgiou
Название: HOX Gene Expression
ISBN: 1441923977 ISBN-13(EAN): 9781441923974
Издательство: Springer
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Цена: 174130.00 T
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Описание: Hox Gene Expression starts with the amazing discovery of the homeobox twenty-three years ago and follows the exciting path thereafter of a series of breakthroughs in Genetics, Development and Evolution. Researchers and graduate students in biology and medicine will benefit from this integrated overview of Hox gene activities.

Автор: Graeme L. Conn
Название: Recombinant and In Vitro RNA Synthesis
ISBN: 1493958305 ISBN-13(EAN): 9781493958306
Издательство: Springer
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Цена: 111790.00 T
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Описание: Part of Springer`s Methods in Molecular Biology series, this collection of detailed protocols guides the reader from the start of a new RNA project to the final sample, with step-by-step protocols and expert tips on deploying catalytic RNAs in the laboratory.

Автор: Rodrick Wallace; Deborah Wallace
Название: Gene Expression and Its Discontents
ISBN: 148998531X ISBN-13(EAN): 9781489985316
Издательство: Springer
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Цена: 204040.00 T
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Описание: This volume examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner.

Автор: Ma
Название: Regulation of Cytokine Gene Expression in Immunity and Diseases
ISBN: 940240919X ISBN-13(EAN): 9789402409192
Издательство: Springer
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Цена: 149060.00 T
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Описание: This book explores the major cytokines, such as IL-1 and IFN-?, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presenting cutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.