Peter Paul De Deyn; Debby Van Dam Animal Models of Dementia 9781493961184

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Автор: Peter Paul De Deyn; Debby Van Dam
Название: Animal Models of Dementia
ISBN: 9781493961184
Издательство: Springer
Классификация:

Неврология и клиническая нейрофизиология

Научное оборудование, научные эксперименты и методы

Биология и науки о жизни

Нейронауки

ISBN-10: 1493961187
Обложка/Формат: Paperback
Страницы: 732
Вес: 1.40 кг.
Дата издания: 23.08.2016
Серия: Neuromethods
Язык: English
Издание: Softcover reprint of
Иллюстрации: 25 tables, black and white; xv, 732 p.; 25 tables, black and white; xv, 732 p.
Размер: 254 x 178 x 38
Читательская аудитория: General (us: trade)
Основная тема: Biomedicine
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.
Дополнительное описание: General Introduction to Animal Models of Human Conditions.- Animal Models of Dementia: Ethical Considerations.- The Role of Rodent Models in the Drug Discovery Pipeline for Dementia.- Species, Strain, and Gender Issues in the Development and Validation of

Animal Models of Dementia, Peter Paul De Deyn; Debby Van Dam