Therapeutic Proteins, Vladimir Voynov; Justin A. Caravella

Автор: Ambikanandan Misra
Название: Challenges in Delivery of Therapeutic Genomics and Proteomics,
ISBN: 0123849640 ISBN-13(EAN): 9780123849649
Издательство: Elsevier Science
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Цена: 104540.00 T
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Описание: Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery.

Автор: Yaffe
Название: Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice, 4e
ISBN: 0781795389 ISBN-13(EAN): 9780781795388
Издательство: Lippincott Williams & Wilkins
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Цена: 172970.00 T
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Описание: Written by experts at the forefront of current research and clinical practice, Neonatal and Pediatric Pharmacology provides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents. Coverage includes specific recommendations for all major drug classes and diseases, a detailed section on drugs and the newborn, and chapters on specific treatment settings such as the pediatric intensive care unit and emergency room. Also included are chapters on adverse effects and interactions and state-of-the-art discussions on pharmacokinetics, pharmacodynamics, pharmacogenetics, pharmacogenomics, pharmacoproteomics, drug development, and clinical trials in infants and children. Appendices include a neonatal formulary and a pediatric formulary. The Fourth Edition includes updated information on drug interactions and regulatory issues. New chapters cover nutrient supplements and biotransformation of medications by the human placenta.

Автор: Marta Cristina Teixeira Duarte; Mahendra Rai
Название: Therapeutic Medicinal Plants: From Lab to the Market
ISBN: 1482254034 ISBN-13(EAN): 9781482254037
Издательство: Taylor&Francis
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Цена: 193950.00 T
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Описание: Medicinal plants have been used in the prevention, diagnosis, and elimination of diseases based on the practical experience of thousands of years.

Автор: Tyagi, Puneet
Название: Oral Delivery Of Therapeutic Peptides And Proteins
ISBN: 0128210613 ISBN-13(EAN): 9780128210611
Издательство: Elsevier Science
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Цена: 174050.00 T
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Описание: Luckily, the parking lot only deleted footage every three months because of the relatively heavy flow of tourism that took place at Cramond Ghost Island during the summer months. The old man in charge of the parking lot security cameras asked us why we needed the footage. Ethan told him that I met someone there at noon on a Saturday in July and that the police needed to verify that this meeting took place on that date. The old man had to review footage of the four Saturdays in July. He grumbled as he escorted us to a small viewing room at the rear end of the parking lot. Ethan and I sat down next to the old man as he began his search. He

Автор: Smales C. Mark, James David C.
Название: Therapeutic Proteins / Methods and Protocols
ISBN: 1588293904 ISBN-13(EAN): 9781588293909
Издательство: Springer
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Цена: 186330.00 T
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Описание: World-class researchers share their innovative and proven techniques for the production of therapeutic proteins downstream of the discovery stage. The methods use a variety of sources for producing therapeutic proteins, including bacterial and yeast expression systems, and insect and mammalian cells, and then cover the purification of the resulting protein using both state-of-the-art and traditional methods, such as those sourced from plasma. Additional chapters offer methods for the characterization of therapeutic proteins throughout the production process, along with methods and strategies for viral inactivation and protein formulation. The protocols follow the successful Methods in Molecular Biologyв„ў series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

Автор: C. Mark Smales; David C. James
Название: Therapeutic Proteins
ISBN: 1627038485 ISBN-13(EAN): 9781627038485
Издательство: Springer
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Цена: 167700.00 T
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Описание: With the recent completion of the sequencing of the human genome, it is widely anticipated that the number of potential new protein drugs and targets will escalate at an even greater rate than that observed in recent years. However, identification of a potential target is only part of the process in developing these new next generation protein-based “drugs” that are increasingly being used to treat human disease. Once a potential protein drug has been identified, the next rate-limiting step on the road to development is the production of sufficient authentic material for testing, charact- ization, clinical trials, and so on. If a protein drug does actually make it through this lengthy and costly process, methodology that allows the production of the protein on a scale large enough to meet demand must be implemented. Furthermore, large-scale production must not compromise the authenticity of the final product. It is also nec- sary to have robust methods for the purification, characterization, viral inactivation and continued testing of the authenticity of the final protein product and to be able to formulate it in a manner that retains both its biological activity and lends itself to easy administration. Therapeutic Proteins: Methods and Protocols covers all aspects of protein drug production downstream of the discovery stage. This volume contains contributions from leaders in the field of therapeutic protein expression, purification, characterization, f- mulation, and viral inactivation.

Автор: P Vyas, Suresh
Название: Smart Polymeric Nano-Constructs In Drug Delivery
ISBN: 0323912486 ISBN-13(EAN): 9780323912488
Издательство: Elsevier Science
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Цена: 174050.00 T
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Описание: Any student of the New Testament must be conscious of the competing expectations in ancient Jewish thought of what and who the Messiah would be. In King and Messiah, Aage Bentzen offers a fascinating glimpse into this topic, which preoccupied the most eminent Scandinavian biblical scholars of the mid-twentieth century.Beginning with the Messiah described in many of the Psalms, representing a demythologised form of the Oriental concept of kingship, Bentzen proceeds to the eschatological Messiah of Isaiah and Micah. He next discusses the later, prophetic-Messianic Moses Redivivus of Deutero-Isaiah, reaching the final

Автор: Ingo K. Mellinghoff; Charles L. Sawyers
Название: Therapeutic Kinase Inhibitors
ISBN: 3642445802 ISBN-13(EAN): 9783642445804
Издательство: Springer
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Цена: 174130.00 T
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Описание:

Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as chemotherapy and still the backbone of most cancer treatment regimens, are increasingly being complemented by or replaced with kinase inhibitors. This new class of drugs targets enzymes which provide growth and survival signals to cancer cells by transferring phosphate groups from Adenosine-5'-triphosphate (ATP) to other proteins, lipids, nucleotides, and carbohydrates.

This book summarizes the current state of kinase inhibitor therapy for cancer. Successful drug development relies on the expertise and dedication of many experts. To reflect this team approach to finding new kinase inhibitors and defining their optimal use for cancer treatment, the editorsinvited experts in academia and pharmaceutical industry to share their insights into various aspects of this process, ranging from the first chemical screens, to preclinical testing and disease-focused clinical drug development. The editors and authorshope these lessons will be instructive for the novice as well as the expert. "

Автор: Sylvia B. Smith; Tsung-Ping Su
Название: Sigma Receptors: Their Role in Disease and as Therapeutic Targets
ISBN: 3319843354 ISBN-13(EAN): 9783319843353
Издательство: Springer
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Цена: 158380.00 T
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Описание: Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets.

Автор: Dinda Biswanath
Название: Natural Products in Obesity and Diabetes: Therapeutic Potential and Role in Prevention and Treatment
ISBN: 3030921956 ISBN-13(EAN): 9783030921958
Издательство: Springer
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Цена: 186330.00 T
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Описание: This book provides a detailed summary of the therapeutic benefits of natural extracts from medicinal plants, mushrooms, algae, fungi and sponges and their role in the prevention and treatment of obesity and diabetes, offering readers a solid introduction to obesity and diabetes as well as current treatment models.

Автор: Wilson Iii David M
Название: Base Excision Repair Pathway, The: Molecular Mechanisms And Role In Disease Development And Therapeutic Design
ISBN: 9814719722 ISBN-13(EAN): 9789814719728
Издательство: World Scientific Publishing
Цена: 274560.00 T
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Описание: This book will serve as the preeminent text book on the topic of "base excision repair", a key DNA repair pathway that protects cells from most spontaneous forms of DNA damage, including oxidative lesions that arise both in the nuclear and mitochondrial genomes.

Автор: Devasena T
Название: Therapeutic and Diagnostic Nanomaterials
ISBN: 981100921X ISBN-13(EAN): 9789811009211
Издательство: Springer
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Цена: 51230.00 T
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Описание: This brief highlights nanoparticles used in the diagnosis and treatment of prominent diseases and toxic conditions. Finally, the brief demonstrates recent developments on the use of nanoparticles in diagnosis or sensing of some biological materials and biologically hazardous environmental materials.