Interleukin-10 in Health and Disease, Simon Fillatreau; Anne O`Garra

Автор: Marek Jankowski; Tomasz Wandtke; Marta Jakubowska
Название: Interleukin-27: Biological Properties and Clinical Application
ISBN: 3319396625 ISBN-13(EAN): 9783319396620
Издательство: Springer
Рейтинг:
Цена: 60940.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer.

Автор: Simon Fillatreau; Anne O`Garra
Название: Interleukin-10 in Health and Disease
ISBN: 3662434911 ISBN-13(EAN): 9783662434918
Издательство: Springer
Рейтинг:
Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.

Автор: J. Wagstaff
Название: The role of interleukin-2 in the treatment of cancer patients
ISBN: 9401047693 ISBN-13(EAN): 9789401047692
Издательство: Springer
Рейтинг:
Цена: 93160.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.

Автор: Luke A. J. O`Neill; Andrew Bowie
Название: Interleukin Protocols
ISBN: 1617371629 ISBN-13(EAN): 9781617371622
Издательство: Springer
Рейтинг:
Цена: 163040.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Interleukins are a family of proteins that regulate the maturation, diff- entiation, or activation of cells involved in immunity and inflammation, and belong to a broader family termed cytokines.

Автор: Steven Gillis
Название: The Interleukins
ISBN: 1468448404 ISBN-13(EAN): 9781468448405
Издательство: Springer
Рейтинг:
Цена: 46570.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Their chapter traces the development of a quantitative assay for assessment of IL-2 receptors based on the preparation and use of radiolabeled IL-2 prepared biosynthetically with the aid of IL-2-pro- ducer leukemic cells.

Автор: Lasek
Название: Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology
ISBN: 3319469053 ISBN-13(EAN): 9783319469058
Издательство: Springer
Рейтинг:
Цена: 56590.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).

Автор: Jan E.de Vries; Rene de Waal Malefyt
Название: Interleukin-10
ISBN: 3662220407 ISBN-13(EAN): 9783662220405
Издательство: Springer
Рейтинг:
Цена: 46570.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The effects of IL-10 in vivo are presented, describing an IL-10 transgenic mouse model, the IL-10 "knock-out" mouse, and the capacity of IL-10 to prevent lethal toxic shock in mice.