Resistance to Immunotherapeutic Antibodies in Cancer, Benjamin Bonavida
Автор: Lasek Название: Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology ISBN: 3319469053 ISBN-13(EAN): 9783319469058 Издательство: Springer Рейтинг: Цена: 56590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).
Автор: Benjamin Bonavida Название: Resistance to Immunotherapeutic Antibodies in Cancer ISBN: 1461476534 ISBN-13(EAN): 9781461476535 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book examines antibody-mediated anti-cancer therapy, covering the use of mAbs against various cancers, developments in the molecular, biochemical and genetic mechanisms of resistance by various mAbs and novel mAbs to overcome drug and radition resistance.
Автор: Rennert Название: Novel Immunotherapeutic Approaches to the Treatment of Cancer ISBN: 3319298259 ISBN-13(EAN): 9783319298252 Издательство: Springer Рейтинг: Цена: 148020.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and include approved antibody drugs directed at the cell surface proteins CTLA4 and PD-1. These are now considered foundational treatments for several solid tumor indications, and that list of indications is growing quickly. More broadly, antibodies have become workhorse molecules across the entire immunotherapy landscape. Antibodies to novel targets modulate the activity of diverse immune cell regulatory proteins. Engineered antibodies can induce tumor cell death or expose tumor cells to poisonous toxins (ADCC and ADC, respectively). Bi-specific antibodies can engage multiple tumor targets simultaneously, or can redirect lymphocytes to attack tumor cells. The antigen-binding domains within antibodies can be spliced onto cell stimulatory domains and transduced into T cells or NK cells, creating remarkable tumor-specific cellular therapeutics (CAR-T, CAR-NK). Beyond antibody-based therapies there are highly diverse and differentiated technology tool kits being applied to immunotherapy. Small molecule drugs are being developed to attack the tumor microenvironment, novel tumor vaccine approaches are showing great promise, patient lymphocytes are being isolated, expanded and reintroduced to patients, gene-editing techniques are becoming widely deployed, and a vast number of new tumor targets, and mutated tumor proteins (neoantigens), are being discovered. The past decade has seen unprecedented success in the treatment of diverse cancers. The authors of this volume have been asked to not only review progress to date, but importantly, to look ahead, and anticipate the evolution of cancer treatment across diverse Immune Therapeutic approaches. Our hypothesis is that the advances we are seeing across the immunotherapy landscape will further evolve and synergize, leading us finally to outright cures for many cancers.
Автор: K.Noel Masihi; Werner Lange Название: Immunotherapeutic Prospects of Infectious Diseases ISBN: 3642761224 ISBN-13(EAN): 9783642761225 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Development of novel regimens for enhancing natural resistance against infections is also progressively gaining in importance. The urgency increases as chemotherapy against viral and other infections further continues to be plagued by a carousel of a limited number of licensed drugs, problems of side effects, and development of drug resistance.
Автор: Antony S. Dimitrov (Ed.) Название: Therapeutic Antibodies ISBN: 1934115924 ISBN-13(EAN): 9781934115923 Издательство: Springer Рейтинг: Цена: 204970.00 T Наличие на складе: Поставка под заказ. Описание: Presents a set of protocols for the discovery and development of therapeutic antibodies, featuring sections focusing on recombinant antigens, antibody libraries, antibody discovery, antibody engineering and antibody preclinical development. This work is suitable for those investigating and participating in this therapeutic market segment.
Автор: Howard Название: Making and Using Antibodies ISBN: 1439869081 ISBN-13(EAN): 9781439869086 Издательство: Taylor&Francis Рейтинг: Цена: 163330.00 T Наличие на складе: Невозможна поставка. Описание:
Antibodies protect us from a wide range of infectious diseases and cancers and have become an indispensable tool in science--both for conventional immune response research as well as other areas related to protein identification analysis. This second edition of Making and Using Antibodies: A Practical Handbook provides clear guidance on all aspects of how to make and use antibodies for research along with their commercial and industrial applications.
Keeping pace with new developments in this area, all chapters in this new edition have been revised, updated, or expanded. Along with discussions of current applications, new material in the book includes chapters on western blotting, aptamers, antibodies as therapeutics, quantitative production, and humanization of antibodies. The authors present clear descriptions of basic methods for making and using antibodies and supply detailed descriptions of basic laboratory techniques. Each chapter begins with introductory material, allowing for a better understanding of each concept, and practical examples are included to help readers grasp the real-world scenarios in which antibodies play a part.
From the eradication of smallpox to combating cancer, antibodies present an attractive solution to a range of biomedical problems. They are relatively easy to make and use, have great flexibility in applications, and are cost effective for most labs. This volume will assist biomedical researchers and students and pave the way for future discovery of new methods for making and using antibodies for a host of applications.
Автор: Michael Steinitz (Editor) Название: Human Monoclonal Antibodies: Methods and Protocols ISBN: 1627035850 ISBN-13(EAN): 9781627035859 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book details readily reproducible protocols of cellular and molecular methods for the production, purification and application of human monoclonal antibodies. It also includes articles on related topics of human monoclonal and polyclonal antibodies.
Автор: David M. Goldenberg Название: Cancer Imaging with Radiolabeled Antibodies ISBN: 0792306317 ISBN-13(EAN): 9780792306313 Издательство: Springer Рейтинг: Цена: 343800.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription.
Автор: Stewart Sell; Ralph Reisfeld Название: Monoclonal Antibodies in Cancer ISBN: 0896030687 ISBN-13(EAN): 9780896030688 Издательство: Springer Рейтинг: Цена: 204040.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Monoclonal antibody technology from its earliest moments has offered revolutionary expectations for the diagnosis and treatment of cancer.
Автор: R. Ceriani Название: Monoclonal Antibodies and Breast Cancer ISBN: 0898387396 ISBN-13(EAN): 9780898387391 Издательство: Springer Рейтинг: Цена: 222670.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the International Workshop on Monoclonal Antibodies and Breast Cancer, held in San Francisco, California, November 8-9, 1984
Автор: David M. Goldenberg Название: Cancer Imaging with Radiolabeled Antibodies ISBN: 1461288053 ISBN-13(EAN): 9781461288053 Издательство: Springer Рейтинг: Цена: 343800.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription.
Автор: Martin Welschof; J?rgen Krauss Название: Recombinant Antibodies for Cancer Therapy ISBN: 1617372501 ISBN-13(EAN): 9781617372506 Издательство: Springer Рейтинг: Цена: 177010.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Since the advent of hybridoma technology more than two decades ago, numerous antibodies have entered the clinical setting as potent therapeutic agents. The purpose of Recombinant Antibodies for Cancer Therapy is to present a collection of detailed protocols in recombinant antibody technology.
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