Central Nervous System Metastasis, the Biological Basis and Clinical Considerations, Diane Palmieri
Автор: Beauchemin Название: Metastasis of Colorectal Cancer ISBN: 9048188326 ISBN-13(EAN): 9789048188321 Издательство: Springer Рейтинг: Цена: 191560.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book covers colon cancer metastasis from fundamental aspects to clinical practice. Major topics include physiopathology, genetic and epigenetic controls, cancer initiating cells, epithelial-mesenchymal transition, growth factors and signalling, and more.
Автор: Wen G. Jiang; R.E. Mansel Название: Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention ISBN: 9401740712 ISBN-13(EAN): 9789401740715 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer.
Автор: Robert B. Dickson; Marc E. Lippman Название: Mammary Tumor Cell Cycle, Differentiation, and Metastasis ISBN: 0792339053 ISBN-13(EAN): 9780792339052 Издательство: Springer Рейтинг: Цена: 483550.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This work is the fifth volume in a series designed to examine advances in the cellular and molecular biology of breast cancer. It looks at mouse models of mammary development and tumorigenesis, as well as studying human breast cancer, focusing on receptors, signalling, and the cell cycle.
Автор: Miriam Dwek; Udo Schumacher; Susan A. Brooks Название: Metastasis Research Protocols ISBN: 1493948873 ISBN-13(EAN): 9781493948871 Издательство: Springer Рейтинг: Цена: 97820.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This new edition offers updates and important new techniques for illuminating the processes underlying research on metastasis. Presents techniques applicable to living cells and tissues, to cell behavior in vitro, to animal models and mathematical constructs.
Автор: Weili He; Jos? Pinheiro; Olga M. Kuznetsova Название: Practical Considerations for Adaptive Trial Design and Implementation ISBN: 149395539X ISBN-13(EAN): 9781493955398 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive trials in saving costs and time, ultimately getting drugs to patients sooner, their adoption in clinical development is still relatively low. One of the chief reasons is the higher complexity of adaptive design trials as compared to traditional trials. Barriers to the use of clinical trials with adaptive features include the concerns about the integrity of study design and conduct, the risk of regulatory non-acceptance, the need for an advanced infrastructure for complex randomization and clinical supply scenarios, change management for process and behavior modifications, extensive resource requirements for the planning and design of adaptive trials and the potential to relegate key decision makings to outside entities. There have been limited publications that address these practical considerations and recommend best practices and solutions. This book fills this publication gap, providing guidance on practical considerations for adaptive trial design and implementation. The book comprises three parts: Part I focuses on practical considerations from a design perspective, whereas Part II delineates practical considerations related to the implementation of adaptive trials. Putting it all together, Part III presents four illustrative case studies ranging from description and discussion of specific adaptive trial design considerations to the logistic and regulatory issues faced in trial implementation. Bringing together the expertise of leading key opinion leaders from pharmaceutical industry, academia, and regulatory agencies, this book provides a balanced and comprehensive coverage of practical considerations for adaptive trial design and implementation.
Neurotechnology in National Security and Defense: Practical Considerations, Neuroethical Concerns is the second volume in the Advances in Neurotechnology series. It specifically addresses the neuroethical, legal, and social issues arising from the use of neurotechnology in national security and defense agendas and applications. Of particular concern are the use of various neurotechnologies in military and intelligence operations training, acquisition of neurobiological and cognitive data for intelligence and security, military medical operations, warfighter performance augmentation, and weaponization of neuroscience and neurotechnology. The contributors discuss the neuroethical questions and problems that these applications generate as well as potential solutions that may be required and developed.
The book examines how developments in neurotechnology in national security and defense agendas are impacted by and affect ethical values and constructs, legal considerations, and overall conduct of the social sphere. Presenting an integrative perspective, leading international experts lay the scientific groundwork and establish the premises necessary to appreciate the ethical aspects of neurotechnology in national security and defense.
It is not a question of "if" neurotechnology will be used in such ways, but when, how, and to what extent. Therefore, it is imperative to foster a deeper understanding of neurotechnology, the problems and debates arising from its use in national security and defense, and how such issues can and should be addressed. In doing so, we can guide and govern the use of these innovative neurotechnologies in ways that uphold ethical accountability.
Автор: Wen G. Jiang; R.E. Mansel Название: Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention ISBN: 0792363957 ISBN-13(EAN): 9780792363958 Издательство: Springer Рейтинг: Цена: 231990.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. This book attempts to examine the status of the basic scientific and clinical research in the area, and is intended for clinicians and oncologists.
Автор: Pnina Brodt Название: Liver Metastasis: Biology and Clinical Management ISBN: 9400735456 ISBN-13(EAN): 9789400735453 Издательство: Springer Рейтинг: Цена: 191550.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Despite recent advances in surgery, and more aggressive resection, liver metastases still prove fatal in a high proportion of cases. This volume aims to enhance our understanding of the biology of hepatic cancer metastasis, in particular its early stages.
Автор: Stanley P. L. Leong Название: Cancer Metastasis and the Lymphovascular System: ISBN: 1489991026 ISBN-13(EAN): 9781489991027 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Sentinel lymph node (SLN) procedures have opened a window of opportunity for the study of micrometastasis. In eighty percent (80%) of metastasis there lies an orderly pattern of progression via the lymphatic network, while 20% of the time systemic metastasis occurs, bypassing the lymphatic system. During the past two decades, significant progress has been achieved in understanding the anatomical, functional, cellular and molecular aspects of the lymphovascular system and the metastasis process. · Molecular imaging advances help to localize early cancers more precisely. · Current status of the immune responses in the draining lymph nodes against cancer is summarized. · New paradigms of early cancer growth, proliferation, overcoming apoptosis are exploited in the development of anticancer treatment. In this book, basic scientists and clinicians exchange ideas so that laboratory findings can be applied to clinical dilemmas, and clinical problems can be targeted for research in the laboratory.
Автор: Welch, Danny R Название: Molecular and Cellular Basis of Metastasis: Road to Therapy,132 ISBN: 0128041404 ISBN-13(EAN): 9780128041406 Издательство: Elsevier Science Рейтинг: Цена: 132500.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Molecular and Cellular Basis of Metastasis: Road to Therapy, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, with this volume covering the molecular and cellular basis of metastasis.
Автор: Anthony J. Mastromarino Название: Biology and Treatment of Colorectal Cancer Metastasis ISBN: 1461294177 ISBN-13(EAN): 9781461294177 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the National Large Bowel Cancer Project 1984 Conference on Biology and Treatment of Colorectal Cancer Metastasis, Houston, Texas, September 13-15, 1984
Автор: J-M. Foidart; R.J. Muschel Название: Proteases and Their Inhibitors in Cancer Metastasis ISBN: 9048161428 ISBN-13(EAN): 9789048161423 Издательство: Springer Рейтинг: Цена: 213360.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors.
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