Chromosomal Mutagenesis, Shondra M. Pruett-Miller

Автор: B. Michael Ghadimi; Thomas Ried
Название: Chromosomal Instability in Cancer Cells
ISBN: 3319202901 ISBN-13(EAN): 9783319202907
Издательство: Springer
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Цена: 79190.00 T
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Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Автор: B. Michael Ghadimi; Thomas Ried
Название: Chromosomal Instability in Cancer Cells
ISBN: 3319349627 ISBN-13(EAN): 9783319349626
Издательство: Springer
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Цена: 74530.00 T
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Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer.

Автор: G. Shashidhar Pai
Название: Handbook of Chromosomal Syndromes
ISBN: 047137217X ISBN-13(EAN): 9780471372172
Издательство: Wiley
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Цена: 178410.00 T
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Описание: This comprehensive reference provides a pictorial and descriptive account of approximately 200 chromosomal aneuploidy syndromes. It focuses exclusively on clinical syndromes due to chromosomal abnormalities.

Автор: David Mittelman
Название: Stress-Induced Mutagenesis
ISBN: 1489994181 ISBN-13(EAN): 9781489994189
Издательство: Springer
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Цена: 174130.00 T
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Описание: This book covers pathways of stress-induced mutagenesis, which may yield models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and other important processes.

Автор: Reeves
Название: In Vitro Mutagenesis
ISBN: 1493964704 ISBN-13(EAN): 9781493964703
Издательство: Springer
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Цена: 167700.00 T
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Описание: In vitro mutagenesis remains a critical experimental approach for investigating gene and protein function at the cellular level. This volume provides a wide variety of updated and novel approaches for performing in vitro mutagenesis using such methods as genome editing, transposon (Tn) mutagenesis, site-directed, and random mutagenesis. In Vitro Mutagenesis: Methods and Protocols guides readers through methods for gene and genome editing, practical bioinformatics approaches for identifying mutagenesis targets, and novel site-directed and random mutagenesis approaches aimed at gaining a better understanding of protein-protein and protein-cofactor interactions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, In Vitro Mutagenesis: Methods and Protocols aims to provide a highly accessible and practical manual for current and future molecular biology researchers, from the beginner practitioner to the advanced investigator in fields such as molecular genetics, biochemistry, and biochemical and metabolic engineering.

Автор: Shondra M. Pruett-Miller
Название: Chromosomal Mutagenesis
ISBN: 1493955411 ISBN-13(EAN): 9781493955411
Издательство: Springer
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Цена: 102480.00 T
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Описание: This new edition explores current and emerging mutagenesis methods focusing specifically on mammalian systems and commonly used model organisms through comprehensive coverage and detailed protocols.

Автор: Greg Davis; Kevin J. Kayser
Название: Chromosomal Mutagenesis
ISBN: 161737833X ISBN-13(EAN): 9781617378331
Издательство: Springer
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Цена: 111790.00 T
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Описание: In Chromosomal Mutagenesis, a team of experts provide a variety of chromosomal manipulation techniques, including insertional gene disruptions, gene knockouts, stimulated homologous recombination techniques and other novel tools, for both prokaryotic and eukaryotic organisms, and attempt to expand the genetic toolbox beyond model organisms.

Автор: G?nter Obe; Adayapalam T. Natarajan
Название: Chromosomal Alterations
ISBN: 3642788890 ISBN-13(EAN): 9783642788895
Издательство: Springer
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Цена: 104480.00 T
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Описание: With contributions by numerous experts

Автор: Janet D. Rowley; Michelle M. Le Beau; Terence H. R
Название: Chromosomal Translocations and Genome Rearrangements in Cancer
ISBN: 331919982X ISBN-13(EAN): 9783319199825
Издательство: Springer
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Цена: 167700.00 T
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Автор: Thomas Liehr
Название: Benign & Pathological Chromosomal Imbalances,
ISBN: 0124046312 ISBN-13(EAN): 9780124046313
Издательство: Elsevier Science
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Цена: 77470.00 T
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Описание: Benign & Pathological Chromosomal Imbalances systematically clarifies the disease implications of cytogenetically visible copy number variants (CG-CNV) using cytogenetic assessment of heterochromatic or euchromatic DNA variants. While variants of several megabasepair can be present in the human genome without clinical consequence, visually distinguishing these benign areas from disease implications does not always occur to practitioners accustomed to costly molecular profiling methods such as FISH, aCGH, and NGS. . As technology-driven approaches like FISH and aCGH have yet to achieve the promise of universal coverage or cost efficacy to sample investigated, deep chromosome analysis and molecular cytogenetics remains relevant for technology translation, study design, and therapeutic assessment. Knowledge of the rare but recurrent rearrangements unfamiliar to practitioners saves time and money for molecular cytogeneticists and genetics counselors, helping to distinguish benign from harmful CG-CNV. It also supports them in deciding which molecular cytogenetics tools to deploy.

Автор: Adam J. Dupuy; David A. Largaespada
Название: Insertional Mutagenesis Strategies in Cancer Genetics
ISBN: 1489981349 ISBN-13(EAN): 9781489981349
Издательство: Springer
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Цена: 139750.00 T
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Описание: The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials.

Автор: A. Kappas
Название: Mechanisms of Environmental Mutagenesis-Carcinogenesis
ISBN: 1461366984 ISBN-13(EAN): 9781461366980
Издательство: Springer
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Цена: 46570.00 T
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Описание: Recent findings, techniques and methodologies in the area of biomonitoring of humans exposed to environmental mutagens-carcinogens were presented and considerable attention was also paid to the aspects and issues of collaborative environmental policy.