Sigma Receptors, Rae R. Matsumoto; Wayne D. Bowen; Tsung Ping Su
Автор: Matsumoto Rae R., Bowen Wayne D., Su Tsung-Ping Название: Sigma Receptors / Chemistry, Cell Biology and Clinical Implications ISBN: 0387365125 ISBN-13(EAN): 9780387365121 Издательство: Springer Рейтинг: Цена: 222670.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. This information is put in a historical perspective to help newcomers to the field successfully navigate the confusing early history surrounding these proteins, and provides a launching point from which future studies and research directions can easily be developed. Major advances in our understanding of sigma receptors have been made during the past few years. This book will facilitate exciting new research that could lead to significant advances in the treatment of neurologic, psychiatric, cardiovascular, immunologic, and gastrointestinal disorders through a better understanding of sigma receptors.
Автор: Sylvia B. Smith; Tsung-Ping Su Название: Sigma Receptors: Their Role in Disease and as Therapeutic Targets ISBN: 3319501720 ISBN-13(EAN): 9783319501727 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets.
Автор: Felix J. Kim; Gavril W. Pasternak Название: Sigma Proteins: Evolution of the Concept of Sigma Receptors ISBN: 3319658514 ISBN-13(EAN): 9783319658513 Издательство: Springer Рейтинг: Цена: 260870.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Two sigma receptor subtypes have been proposed, sigma1 and 2. Largely based on traditional pharmacologic approaches, the Sigma1 protein has been associated with a broad range of signaling systems, including G-protein coupled receptors, NMDA receptors, and ion channels.
Автор: Rast Название: Immune Receptors ISBN: 1617791385 ISBN-13(EAN): 9781617791383 Издательство: Springer Рейтинг: Цена: 135090.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Immunology has made significant progress in the past decade, driven forward by rapidly advancing technology and a renewed interest in the vast realm of innate immunity. The receptors that mediate these functions are at the front lines of both protective and regulative roles of the immune system. In Immune Receptors: Methods and Protocols, expert researchers present a variety of experimental approaches to the characterization of immune receptors and the cell biology that mediates their functions. These include imaging techniques that aim to understand receptor localization and trafficking, techniques to measure receptor-ligand interactions, strategies to identify novel ligands and methods to analyze downstream receptor signaling, as well as strategies for genomic and proteomic characterization of receptor repertoires. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immune Receptors: Methods and Protocols offers technical descriptions and protocols that will be useful both to investigators who are interested in carrying out these procedures and to those who seek a deeper understanding of the bench science that lies behind the immunology literature.
Forward, Mary Ann Asson-Batres and Cecile Rochette-Egly
1 History of Retinoic Acid Receptors Doris M. Benbrook, Pierre Chambon, Cecile Rochette-Egly, and Mary Ann Asson-Batres 2 Architecture of DNA Bound RAR Heterodimers Natacha Rochel and Dino Moras 3 Retinoic Acid Receptors: Structural Basis for Coregulator Interaction and Exchange Albane le Maire and William Bourguet 4 Evolution of Retinoic Acid Receptors and Retinoic Acid Signaling Juliana Gutierrez-Mazariegos, Michael Schubert and Vincent Laudet 5 RXRs: Collegial Partners Federica Gilardi and Bйatrice Desvergne 6 Nuclear and Extra-Nuclear Effects of Retinoic Acid Receptors: How they are interconnected Aleksandr Piskunov, Ziad Al Tanoury, and Cйcile Rochette-Egly 7 The Roles of Retinoic Acid and Retinoic Acid Receptors in Inducing Epigenetic Changes Alison Urvalek, Kristian Laursen, and Lorraine J. Gudas 8 RARs and microRNAs Clara Nervi and Francesco Grignani 9 Integrative genomics to dissect retinoids functions Marco-Antonio Mendoza-Parra and Hinrich Gronemeyer 10 Complexity of the RAR‐Mediated Transcriptional Regulatory Programs Zhijie Liu, Qidong Hu and Michael G. Rosenfeld Index.
Автор: Marc Daeron; Falk Nimmerjahn Название: Fc Receptors ISBN: 3319379097 ISBN-13(EAN): 9783319379098 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection.
Автор: Craig W. Stevens Название: Methods for the Discovery and Characterization of G Protein-Coupled Receptors ISBN: 1493958518 ISBN-13(EAN): 9781493958511 Издательство: Springer Рейтинг: Цена: 135090.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book presents the latest methods and technology used to characterize and discover novel mechanisms of G protein-coupled receptors (GPCRs) which, in many cases, can be used directly to design experiments for the reader`s particular GPCR of interest.
Автор: Jonathan P. Rast; James W.D. Booth Название: Immune Receptors ISBN: 1493957988 ISBN-13(EAN): 9781493957989 Издательство: Springer Рейтинг: Цена: 135090.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book presents technical descriptions and protocols for a variety of experimental approaches to the characterization of immune receptors and the cell biology that mediates their functions. Written in the successful Methods in Molecular Biology (TM) format.
Автор: Santi M. Spampinato Название: Opioid Receptors ISBN: 1493955500 ISBN-13(EAN): 9781493955503 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Opioid Receptors: Methods and Protocols serves as a comprehensive guide to both key new techniques and established methods for the investigation of genetics, structural biology, transcription, and post-transcriptional events of opioid receptors. Other methods cover the cellular detection and trafficking of opioid receptors in vitro and in vivo. Procedures aimed to investigate signaling pathways modulated by opioid receptors and model systems to study opioid receptor-mediated functions are also included. Finally, methods to assay behavioral effects mediated by opioid receptors are described. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective introductions, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Wide-ranging and authoritative, Opioid Receptors: Methods and Protocols will help both experienced and new entrants in this field to carry out their experiments successfully and with new inspiration.
Автор: Bruce G. Allen; Terence E. H?bert Название: Nuclear G-Protein Coupled Receptors ISBN: 1493955462 ISBN-13(EAN): 9781493955466 Издательство: Springer Рейтинг: Цена: 88500.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Nuclear G-Protein Coupled Receptors: Methods and Protocols is a compilation of a number of conceptual and methodological aspects important for the validation and characterization of intacrine signaling systems.
Автор: Adam C. Errington; Giuseppe Di Giovanni; Vincenzo Название: Extrasynaptic GABAA Receptors ISBN: 1493953214 ISBN-13(EAN): 9781493953219 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Whereas synaptic GABAA receptors underlie classical "phasic" GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA.
Автор: Claire McCoy Название: Toll-Like Receptors ISBN: 1493933337 ISBN-13(EAN): 9781493933334 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This second edition volume expands on the first edition with new developments on Toll-Like Receptors (TLRs) controlling events such as cross-priming of associated pattern recognition receptors, post-transcriptional regulation, interaction with other cellular and biologic systems, and cancer progression.
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