Christoph Stein Analgesia 9783642439315

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Автор: Christoph Stein
Название: Analgesia
ISBN: 9783642439315
Издательство: Springer
Классификация:

Психология

Ревматология

Обезболивающие средства

Фармакология

Хирургия

Нейрохирургия

ISBN-10: 3642439314
Обложка/Формат: Paperback
Страницы: 435
Вес: 0.62 кг.
Дата издания: 30.10.2014
Серия: Handbook of Experimental Pharmacology
Язык: English
Издание: 2007 ed.
Иллюстрации: 8 tables, black and white; viii, 435 p.
Размер: 157 x 235 x 29
Читательская аудитория: Professional & vocational
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample,theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was ?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use. It also gives - sights into current efforts to discover novel mechanisms underlying different types of pain generation and the resulting development of new modulating compounds. Theseefforts haveemergedmostlyas aconsequenceofthemore profound insights provided by molecular methods and of the now common use of animal models of pathological, rather than physiological, pain. These important issues are elaborated in the introductory chapter. In parallel, c- temporaryinterdisciplinarytreatmentapproacheshavetaughtusthatsomatic mechanisms alone cannot explain pain; it is an experience shaped as well by social context, memory, and other psychological phenomena. Thus, the book closes with two chapters putting pharmacological strategies into a broader perspective. All of these advancements culminate in the contemporary c- mon goal of developing mechanism-based rather than empiric approaches to thetreatment ofpain.
Дополнительное описание: Peripheral and Central Mechanisms of Pain Generation.- Drugs in Clinical Use.- Opioids.- Antipyretic Analgesics: Nonsteroidal Antiinflammatory Drugs, Selective COX-2 Inhibitors, Paracetamol and Pyrazolinones.- Local Anesthetics.- Serotonin Receptor Ligand

Analgesia, Christoph Stein