Deodutta Roy; M. Tevfik Dorak Environmental Factors, Genes, and the Development of Human Cancers 9781489982193

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Автор: Deodutta Roy; M. Tevfik Dorak
Название: Environmental Factors, Genes, and the Development of Human Cancers
ISBN: 9781489982193
Издательство: Springer
Классификация:

Онкология

Фармакология

Медицина с ориентацией на окружающую среду

ISBN-10: 1489982191
Обложка/Формат: Paperback
Страницы: 520
Вес: 0.74 кг.
Дата издания: 20.10.2014
Язык: English
Издание: 2010 ed.
Иллюстрации: 26 tables, color; xiii, 520 p.
Размер: 234 x 156 x 27
Читательская аудитория: Professional & vocational
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Cancer is a complex disease. Only 5-10% of human cancers are hereditary in nature. Many of us think of environmental agents when we think of carcinogens. The environment includes all that surrounds us, and environmental influences include not only chemical, physical and biological toxicants, but also diet and lifestyle. In this broadest sense, the environment contributes substantially in the development of human cancer. This book will describe how environment contributes to malignant transformation leading to profound changes in the genetic and signaling networks that control the functioning of the cell. It will critically discuss the understanding of the effects of environment on the development, progression and metastasis of cancer with current knowledge of the signaling networks that support functioning of transformed human cells. Genes and environmental factors that influence the origins of cancer are not necessarily the same as those that contribute to its progression and metastasis. Susceptibility gene variants for each specific cancer are being identified with emerging evidence of gene–environment interaction. Gene-environment interactions will be discussed through each specific cancer-based approach to address the question of how genetic variations can influence susceptibility to the individual type of cancer. It will also highlight and summarize epigenetic changes that increase the risk for susceptibility to a particular type of cancer, particularly in the presence of specific environmental factors. Thus, this book will contain chapters from the world’s experts focused on the current evidences that support the role of environment in the cancer etiology and in the growth of malignant lesions, and discuss who may be susceptible to environmental influences.
Дополнительное описание: General Principles.- Gene–Environment Interactions, Phenotypic Changes, and Human Health.- Statistics for Testing Gene–Environment Interaction.- Clustering Studies for Identifying the Role of Environmental Factors in Aetiology of Human Cancers.- Discoveri

Environmental Factors, Genes, and the Development of Human Cancers, Deodutta Roy; M. Tevfik Dorak