Opioid Receptors, Santi M. Spampinato

Автор: Santi M. Spampinato
Название: Opioid Receptors
ISBN: 1493955500 ISBN-13(EAN): 9781493955503
Издательство: Springer
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Цена: 111790.00 T
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Описание: Opioid Receptors: Methods and Protocols serves as a comprehensive guide to both key new techniques and established methods for the investigation of genetics, structural biology, transcription, and post-transcriptional events of opioid receptors. Other methods cover the cellular detection and trafficking of opioid receptors in vitro and in vivo. Procedures aimed to investigate signaling pathways modulated by opioid receptors and model systems to study opioid receptor-mediated functions are also included. Finally, methods to assay behavioral effects mediated by opioid receptors are described. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective introductions, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Wide-ranging and authoritative, Opioid Receptors: Methods and Protocols will help both experienced and new entrants in this field to carry out their experiments successfully and with new inspiration.

Автор: A.F. Casy; R.T. Parfitt
Название: Opioid Analgesics
ISBN: 1489905871 ISBN-13(EAN): 9781489905871
Издательство: Springer
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Цена: 186330.00 T
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Описание: The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics and opioid receptors makes this exhaustive review of opioid anal­ gesics particularly relevant and timely. After an introductory chapter the additional 12 chapters begin logically with morphine and congeners (4- epoxymorphinans) and end with opioid receptors. All principal chemical types of centrally acting analgesics (including endogenous opioid-like substances) and their antagonists as well as the mixed agonist-antagonists are treated thoroughly, although not always (and for good reason) in historical (chrono­ logical) order. A chapter on miscellaneous types (atypical structures for the most part) includes the benzimidazoles (etonitazene), aminotetralins (dezocine), tetrahydroisoquinolines (methopholine), and so on. Important aspects and correlations of chemistry, pharmacology, and biochemistry are discussed in depth. Literature citations are numerous. For educators, practicing laboratory scientists, and physicians, this scholarly review by two authors well of opioid analgesics versed in the chemistry, pharmacology, and biochemistry will be informative, stimulating, and thought-provoking. Everette L. May Medical College of Virginia Richmond, VA 23298 v Preface The history of opium predates the written word, although knowledge of its constituents dates back less than 200 years. Over the centuries its popularity for the relief of pain has waxed and waned, until today the opiates are widely recognized as excellent analgesics but with disadvantages that have impaired their use seriously. There is a clear need for a potent analgesic with minimal effects on the respiratory centers and gastrointestinal tract and preferably devoid of dependence liability.

Автор: Smith Howard S.
Название: Opioid Therapy in the 21st Century
ISBN: 0199844976 ISBN-13(EAN): 9780199844975
Издательство: Oxford Academ
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Цена: 50150.00 T
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Описание: Opioid Therapy in the 21st Century, Second Edition provides clinicians with up-to-date, evidence-based information about appropriate opioid use, including the potential benefits and adverse affects of the therapy.

Автор: Osborne F.X. Almeida; A. Goldstein; Toni S. Shippe
Название: Neurobiology of Opioids
ISBN: 3642466621 ISBN-13(EAN): 9783642466625
Издательство: Springer
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Цена: 93160.00 T
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Описание: Dedicated to Professor Albert Herz, a leading investigator in opioid research, this book provides comprehensive information on the biology of exogenous and endogenous opioids.

Автор: H. Akil; S. Archer; A. Beaumont; M. Blum; D. Brons
Название: Opioids I
ISBN: 3642774628 ISBN-13(EAN): 9783642774621
Издательство: Springer
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Цена: 113190.00 T
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Описание: This two-volume book provides the first comprehensive survey of opioid research, a field which has accumulated a tremendous amount of literature since the identification of opioid receptors and their endogenous ligands.

Автор: M.W. Adler; O.F.X. Almeida; P.L. Bailey; A.J. Bert
Название: Opioids II
ISBN: 364277542X ISBN-13(EAN): 9783642775420
Издательство: Springer
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Цена: 113190.00 T
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Описание: This two-volume book provides the first comprehensive survey of opioid research, a field which has accumulated a tremendous amount of literature since the identification of opioid receptors and their endogenous ligands.

Автор: Ying Xia
Название: Neural Functions of the Delta-Opioid Receptor
ISBN: 3319254936 ISBN-13(EAN): 9783319254937
Издательство: Springer
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Цена: 191560.00 T
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Описание: This book is the first to summarize the progress of research on neural functions of the the delta opioid receptor (DOR) to date. The book will provide a comprehensive overview of the current state of DOR research and provide a blueprint for future directions.ГЇВїВЅ

Автор: K.O. Stumpe; Karin Kraft; Alan I. Faden
Название: Opioid Peptides and Blood Pressure Control
ISBN: 3540189351 ISBN-13(EAN): 9783540189350
Издательство: Springer
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Цена: 102480.00 T
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Описание: A. , FADEN, K. KRAFr, and K. O. STUMPE Following the discovery of the pentapeptide enkephalins in 1975, a number of endogenous opioid peptides and opiate receptors have been identified. Endogenous opioids and opiate-receptor mechanisms have been implicated in a variety of regulat- ory and dysregulatory functions including analgesia, cardiovascular regulation, shock, hypertension, traumatic spinal cord and brain injury, stroke, immune func- tion, feeding behavior, diuresis, gastrointestinal motility, and respiratory control, among others. Over the past 10 years, many studies have demonstrated a relationship between endogenous opioids and the cardiovascular system under both homeostatic and pathophysiological conditions. Opioids and opiate receptors have been found in various cardioregulatory sites within the brain and spinal cord, as well as in peripheral tissues such as sympathetic ganglia, adrenal gland, and heart. Both endogenous opioids and exogenous opiates have been shown to produce potent cardiovascular effects following central nervous system or systemic administration. Opiate-receptor antagonists have been demonstrated to reverse hypotension from sepsis, hypo- volemia, and anaphylaxis; such studies have been used to infer activity of endogenous opioid systems in shock. Changes in tissue concentrations of endogenous opioids and or opiate receptors have been found after shock and hypertension, further implying a role for opioid systems in the etiology of these conditions. In addition, modification of opiate receptor regulation, receptor binding, or opioid metabolism has also been used to establish a potential role for endogenous opioid systems in cardiovascular control and dyscontrol.

Автор: Larry D. Reid
Название: Opioids, Bulimia, and Alcohol Abuse & Alcoholism
ISBN: 1461390028 ISBN-13(EAN): 9781461390022
Издательство: Springer
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Цена: 46570.00 T
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Описание: This text is the written form of the proceedings of a satellite symposium associated with the 1988-meeting of the Society for Neu roscience. The symposium was sponsored by the Addictions Research Foundation, Toronto, Canada, the National Institute on Alcohol Abuse and Alcoholism, U.

Автор: Craig W. Stevens
Название: Methods for the Discovery and Characterization of G Protein-Coupled Receptors
ISBN: 1493958518 ISBN-13(EAN): 9781493958511
Издательство: Springer
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Цена: 135090.00 T
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Описание: This book presents the latest methods and technology used to characterize and discover novel mechanisms of G protein-coupled receptors (GPCRs) which, in many cases, can be used directly to design experiments for the reader`s particular GPCR of interest.

Автор: Adam C. Errington; Giuseppe Di Giovanni; Vincenzo
Название: Extrasynaptic GABAA Receptors
ISBN: 1493953214 ISBN-13(EAN): 9781493953219
Издательство: Springer
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Цена: 130590.00 T
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Описание: Whereas synaptic GABAA receptors underlie classical "phasic" GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA.

Автор: Olimpia Meucci
Название: Chemokine Receptors and NeuroAIDS
ISBN: 1489984879 ISBN-13(EAN): 9781489984876
Издательство: Springer
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Цена: 158380.00 T
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Описание: Since their discovery as HIV co-receptors in 1996, chemokine receptors have been widely studied within the field of HIV pathogenesis, including neuroAIDS. However, though their role in infection of target cells and in inflammatory/immune responses is relatively well-characterized, their relevance with respect to neuropathogenesis is still unclear.