M. Kurowski Adverse Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Pharmacoepidemiology 9783034857246

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Автор: M. Kurowski
Название: Adverse Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Pharmacoepidemiology
ISBN: 9783034857246
Издательство: Springer
Классификация:

Фармакология

ISBN-10: 3034857241
Обложка/Формат: Paperback
Страницы: 104
Вес: 0.20 кг.
Дата издания: 23.08.2014
Серия: Advances in Pharmacological Sciences
Язык: English
Размер: 244 x 170 x 6
Основная тема: Science, Humanities and Social Sciences, multidisciplinary
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Non-steroidal anti-inflammatory drugs (NSAIDs) are among the mostfrequently- prescribed drugs in the Western world. During the past decade a large number of new compounds were marketed, some of which had to be withdrawn after a short while because of adverse drug reactions. These experiences led to an under- standing that a complete picture of the safety of these drugs can only be obtained after their introduction into the marketplace.

Differentmethods ofpost-marketing surveillance (PMS) serve as important tools for monitoring the frequency of adverse reactions and for generating and corroborating hypotheses. Experience with PMS has thusfar been quite limited in Germany. In 1987 a non-profit organization, Verein zur Langzeituntersuchung von Arzneimittel- wirkungen auf dem Gebiet der Rheumatologie e.

V. (VLAR) was founded by interested physicians and pharmacologists to raise funds and perform investiga- tions on the safety of NSAIDs. The first project by the VLAR, SPALA (Safety Profile of Antirheumatics in Long-Term Administration), was sponsored by F.

Hoffmann-La Roche AG (Basel, Switzerland). In July 1990, when the project was successfully terminated, almost 30,000 patients had been completely docu- mented and their medical records entered into a computer for subsequent review by a select panel of experts with experience in monitoring adverse reactions to NSAIDs. The comments, criticisms, and ideas of these experts were brought togetherat a symposium organized by the VLAR at the Klinikum Steglitz (Berlin, Germany) on 12 October 1990.

Adverse Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Pharmacoepidemiology, M. Kurowski