Transgenic Animals as Model Systems for Human Diseases, Erwin F. Wagner; F. Theuring

Автор: Igor K. Egorov; Chella S. David
Название: Transgenic Mice and Mutants in MHC Research
ISBN: 3642754449 ISBN-13(EAN): 9783642754449
Издательство: Springer
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Цена: 102480.00 T
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Описание: This volume contains papers presented at the international conference on "Transgenic Mice and Mutants in MHC Research," held in Bar Harbor, Maine, in June, 1989. The meeting brought together eighty researchers working in the field. While mouse H-2 mutants have been known for many years their studies continue to contribute a great deal to our understanding of structure/function relationships and evolution of MHC molecules. Recently a new direction of research has emerged on regulation, expression and function of MHC genes using transgenic animals carrying exogenous MHC genes from the same or other species or engineered MHC genes. With the introduction of transgenic mice more specific questions about the various functions of MHC genes can be answered as, for example, the role of soluble and membrane-bound MHC molecules in self tolerance and elimination of specific T cell clones, recognition of human MHC antigens by the mouse immune system, the role of individual human MHC genes in disease susceptibility. New approaches for evaluation of the role of MHC linked and unlinked genes in susceptibility of mice to malignant tumors and their metastases have been also reported. Our purpose has been to provide a forum for discussion of these new developments. Many questions remain to be answered but the necessary tools have become available. We thank the contributors and hope that the readers will benefit from this Pro- ceedings. We wish to acknowledge the financial sponsorship for the meeting by The Pew Charitable Trust and Howard Hughes Medical Institute.

Автор: V. Kumar
Название: Trematode Infections and Diseases of Man and Animals
ISBN: 904815152X ISBN-13(EAN): 9789048151523
Издательство: Springer
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Цена: 191550.00 T
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Описание: Over the last few decades new data on the distribution, pathogenicity, diagnosis, treatment and control of trematode infections and diseases in man and animals, including zoonotic trematodiasis, have emerged from various geographical regions. These new data are compiled in this book together with existing information to fulfil the present need. Seven major trematode-induced disease groups, namely, schistosomiasis, paragonimiasis, fascioliasis and fasciolopsiasis, dicrocoeliasis and eurytremiasis, clonorchiasis and opisthorchiasis, paramphistomiasis, and diseases due to intestinal trematode infections are dealt with in this book. These diseases still rank as a major cause of morbidity and mortality - both in man and in livestock - mainly in the tropics, and contribute to the socio-economic problems. Many of these diseases are also zoonoses, some major and others potential.
The intended readership of this treatise include postgraduate students of medical and veterinary parasitology, research workers as well as medical practitioners, veterinarians, tropical diseases specialists, veterinary public health specialists and teachers concerned with trematode infections and trematodiasis of man and animals.