Manipulation of Mammalian Development, Ralph B.L. Gwatkin

Автор: Damir Janigro
Название: Mammalian Brain Development
ISBN: 1607612860 ISBN-13(EAN): 9781607612865
Издательство: Springer
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Цена: 213360.00 T
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Описание: Focuses on the pre-natal and the peri-natal events that lead to brain damage as seen in the prospective of medical and research professionals, as well as examining the traditional `nature versus nurture` argument in the spectrum of brain development. This book covers sexual dimorphism and epigenetic action of gonadal hormones.

Автор: Damir Janigro
Название: Mammalian Brain Development
ISBN: 1617796484 ISBN-13(EAN): 9781617796487
Издательство: Springer
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Цена: 213360.00 T
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Описание: By focusing on both the pre-natal and the peri-natal events that lead to brain damage, this book fills a gap in developmental books dealing with the normal prenatal mammalian brain. It also covers aspects of postnatal and pediatric neurological disorders.

Название: Somatic genome manipulation
ISBN: 1493923889 ISBN-13(EAN): 9781493923885
Издательство: Springer
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Цена: 149060.00 T
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Описание: Somatic genome manipulation is required when a sexual crossing approach cannot be used in breeding or genetic treatment of an individual organism. Examples can include gene- or cell-therapy of a person to correct disease, genetic improvement of vegetatively propagated plants, and genetic replacement of cytoplasm without significantly modifying the nuclear genome. The advantage of somatic genome manipulation is maintenance of the general genotype while correcting one or more traits. Somatic genome manipulation is also an option for genetic improvement of sexually propagated plants in polyploidy breeding or in overcoming issues of sexual incompatibility. Recent novel technologies in somatic genome manipulation are developing quickly but much of this literature is fragmented and difficult or inconvenient to access. This book represents the first attempt to assemble updated reviews, detailed protocols, and their applications in all fields in which somatic genome manipulation has thrived. This is a truely one-of-a-kind work that brings together the most important and relevant advances in somatic genome manipulation in plants, algae, microorganisms, humans and animals, and demonstrates where the science interacts and where it diverges. The chapters are written by experts on the topic with ready-to-use protocols that were originally developed or adapted from the literature in their laboratories. We expect that this book will be useful for students, researchers, and teachers in both plant and animal research as a resource for the latest information on somatic genome manipulation and for its useful laboratory methods.

Автор: J. Perry Gustafson
Название: Gene Manipulation in Plant Improvement
ISBN: 1461294789 ISBN-13(EAN): 9781461294788
Издательство: Springer
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Цена: 130430.00 T
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Описание: The results obtained to date involving the use of in ~ methods to facilitate wide hybridization in plants are voluminous and impressive. The techniques of embryo culture, ovule culture, and in~ pollination and fertilization represent an extension of the normal sexual hybridization process. Successes recorded in obtaining hybrids stem largely from circumventing prezygotic or postzygotic hybridization barriers. Numerous recent successful hybridizations were possible because of the development of improved tissue and cell culture systems for crop plants and attention given to genotypes used in hybridization attempts. Interspecific and intergeneric hybridization utilizing the process of protoplast fusion will bypass the limits set by all sexual me'thods. In addition to combining complete genomes from two different species through protoplast fusion, this system affords unique opportunities for creating novel cytoplasmic combinations, transfer of individual chromosomes, transfer of cytoplasmic organelles, manipulation of male sterility, and for single gene transfer. Some caution must be noted with regard to the extent of hybridization possible between distantly related species. Although practically no limit exists to the physical fusion of protoplasts from widely divergent species, the restrictions imposed by somatic incompatibility have not been adequately addressed. Regeneration of plants from the protoplast or single heterokaryon level is still a major hurdle for many important crop species before somatic cell fusion can be exploited to produce interspecific and intergeneric hybrids. Identification and selection of hybrids is also a limitation to the efficient application of cell fusion methods.

Автор: DePamphilis, Melvin L
Название: Mammalian Preimplantation Development,120
ISBN: 0128014288 ISBN-13(EAN): 9780128014288
Издательство: Elsevier Science
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Цена: 174050.00 T
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Описание:

Mammalian Preimplantation Development, the latest volume in the Current Topics in Developmental Biology series covers mammalian preimplantation development, and includes contributions from an international board of authors. The book's chapters provide a comprehensive set of reviews covering such topics as cell proliferation, cell differentiation, and biological significance.

Автор: Henry J. Leese; Daniel R. Brison
Название: Cell Signaling During Mammalian Early Embryo Development
ISBN: 1493924796 ISBN-13(EAN): 9781493924790
Издательство: Springer
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Цена: 139750.00 T
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Описание: The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.