Steroid Hormone Resistance, George P. Chrousos; D. Lynn Loriaux; Mortimer B. L
Автор: Arun K. Roy; James H. Clark Название: Gene Regulation by Steroid Hormones IV ISBN: 1461281970 ISBN-13(EAN): 9781461281979 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The first Meadowbrook Symposium was held in 1978 and during the intervening ten years our knowledge concerning how steroid hormones function at the level of gene expression has advanced by leaps and bounds.
Автор: Lieberman Benjamin A. Название: Steroid Receptor Methods / Protocols and Assays ISBN: 0896037541 ISBN-13(EAN): 9780896037540 Издательство: Springer Рейтинг: Цена: 144410.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A distinguished team of principal investigators and their associates describe in step-by-step detail a cross-section of the latest research techniques available for studying the endocrine system. As a basis for sophisticated biochemical analysis of receptor properties, the contributors provide methods for the production and purification of a variety of receptors, including progesterone, glucocorticoid, and androgen. Other protocols allow the reader to experiment with DNA binding characteristics, hormone binding assays, and the use of combinatorial chemistry for drug discovery. A series of novel methods utilizing the latest advances in immunochemistry, yeast two-hybrid screening, and fluorescence are included for the detection and analysis of a variety of cellular proteins that influence steroid receptor effectiveness.
Автор: Behl Christian Название: Estrogen - Mystery Drug for the Brain? / The Neuroprotective Activities of the Female Sex Hormone ISBN: 3211835393 ISBN-13(EAN): 9783211835395 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: It is well known that estrogen is "somehow” a protective hormone for various age-related disorders. This book provides a solid knowledge of estrogen’s neuroprotective activities in the brain with a special emphasis on neurodegenerative disorders such as Alzheimer’s Disease. The focus is (1) to describe the biochemical, molecular, and cellular basis of the protective activity of estrogen and (2) to transfer this knowledge into the hospitals by discussing preventive and therapeutic approaches such as estrogen replacement therapy for post-menopausal women. Besides up-to-date information on estrogen and the brain, this book explains in a highly understandable manner molecular and cellular techniques by which basic data have been collected. The reader, which may include the professional specialist as well as the interested non-specialist, will also gain insight into the scientific transfer process of knowledge from basic science to the clinical situation and therefore "from bench to bed”.
Автор: Luck Martin Название: Hormones: A Very Short Introduction ISBN: 0199672873 ISBN-13(EAN): 9780199672875 Издательство: Oxford Education Рейтинг: Цена: 8350.00 T Наличие на складе: Есть Описание: Hormones are vital to the workings of the body, and while many people are aware of what hormones do, few have an appreciation of the nature and importance of the endocrine system. In this Very Short Introduction, Martin Luck explains what hormones are, what they do, where they come from, and how they work.
Автор: G.A.W. Rook; S. Lightman Название: Steroid Hormones and the T-Cell Cytokine Profile ISBN: 1447112385 ISBN-13(EAN): 9781447112389 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The fact that certain adrenal steroid hormones are immunosuppressive and anti-inflammatory has been known for many years, and is routinely exploited by physicians. These effects are attributable to glucocorticoid steroids such as cortisol. Pharmacological doses of glucocorticoids inhibit most or all T cell types. However we now know that the effect of exposure to raised physiological levels is mainly to drive developing lymphocyte responses towards a Th2 cytokine profile (interleukin-4 secreting) while suppressing the development ofThi (gamma interferon- secreting) lymphocytes. Only recently have two further regulatory mechanisms become appar- ent. First, these effects of cortisol are balanced by pro-inflammatory and ThI-enhancing effects of another adrenal steroid, dehydroepiandro- sterone sulfate (DHEAS). Second, the activity of cortisol is directly modulated by enzymes in the target organs and lymphoid tissues that convert it into inactive cortisone. This new information leads to the possibility that immunoregulatory steroids could be used by physicians in novel ways. We can envisage steroid combinations that exploit the anti-inflammatory effects of corti- sol, while the Thi-suppressing and Th2-promoting properties of these hormones are opposed by derivatives of DHEAS. Such therapies are already proving effective in animal models of infection, and could revol- utionize treatment of Th2-mediated diseases such as asthma, where the anti-inflammatory effects of cortisol are desirable but the effects on T lymphocyte differentiation are not.
Автор: A.K. Roy; J.H. Clark Название: Gene Regulation by Steroid Hormones II ISBN: 1461254841 ISBN-13(EAN): 9781461254843 Издательство: Springer Рейтинг: Цена: 130610.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Receptors and Gene Expression It is now more than three years since the last Meadow Brook Conference on Hormones, and a great deal has happened in the meantime. Steroid hormones have been localized on target genes providing the long awaited evidence for the concept of a direct effect of the steroid-receptor complex on gene regulation.
Автор: Michael N. Alexis; Constantin E. Sekeris Название: Activation of Hormone and Growth Factor Receptors ISBN: 9401073643 ISBN-13(EAN): 9789401073646 Издательство: Springer Рейтинг: Цена: 245040.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the NATO Advanced Research Workshop, Nafplion, Greece, September 25-30, 1988
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