Immunogenetics and Immunodeficiency, B. Benacerraf

Автор: Hans D. Ochs,, C. I. Edvard Smith
Название: Primary Immunodeficiency Diseases A Molecular and Cellular Approach Third Edition
ISBN: 0195389832 ISBN-13(EAN): 9780195389838
Издательство: Oxford Academ
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Цена: 335280.00 T
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Описание: This third edition of Primary Immunodeficiency Diseases provides readers with the historic and scientific background, clinical presentations, immunologic characteristics, and the molecular/genetic underpinnings of this rapidly enlarging class of diseases.

Автор: A.D.B Webster
Название: Immunodeficiency and Disease
ISBN: 9401070660 ISBN-13(EAN): 9789401070669
Издательство: Springer
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Цена: 95770.00 T
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Описание: The AIDS epidemic has popularized immune deficiency and has led to a rapid increase in the funding for research into the effect of viruses on immunity. AIDS is an important precedent, and it is likely that other less pathogenic retroviruses will eventually turn dut to cause some of the rarer immunodeficiency disorders in children and adults.

Автор: J.A. Madrigal; Tibor N?n?si; Margita Bencov?; Dere
Название: Immunogenetics: Advances and Education
ISBN: 9401063087 ISBN-13(EAN): 9789401063081
Издательство: Springer
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Цена: 214290.00 T
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Описание: Proceedings of the NATO Advanced Research Workshop, held in Casta-Papiernicka, Bratislava, Slovak Republic, September 5-9, 1996

Автор: Leslie L. Barton; J.J. Volpe; Neil R. Friedman
Название: The Neurological Manifestations of Pediatric Infectious Diseases and Immunodeficiency Syndromes
ISBN: 1617378585 ISBN-13(EAN): 9781617378584
Издательство: Springer
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Цена: 231990.00 T
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Описание: In this concise book, an international panel of experts provide a succinct, up-to-date, evidence-based reference to the neurological consequences of infectious diseases and immunodeficiency syndromes in children in one readily accessible volume.

Название: Primary immunodeficiency diseases
ISBN: 354078537X ISBN-13(EAN): 9783540785378
Издательство: Springer
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Цена: 107130.00 T
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Описание: Primary immunodeficiency diseases (PID) are a group of disorders involving defects in one or more components of the immune system, and are characterized by an increased incidence of infections, autoimmunity, and malignancies. This book contains advances in the field.

Автор: Herman Friedman; Thomas W. Klein; Steven Specter
Название: Drugs of Abuse, Immunity, and Immunodeficiency
ISBN: 1468459279 ISBN-13(EAN): 9781468459272
Издательство: Springer
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Цена: 113190.00 T
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Описание: Proceedings of a symposium held in Clearwater Beach, Florida, December 13--15, 1989

Автор: Ochs, Hans D.; Smith, C. I. Edvard; Puck, Jennifer
Название: Primary Immunodeficiency Diseases
ISBN: 019514774X ISBN-13(EAN): 9780195147742
Издательство: Oxford Academ
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Цена: 129360.00 T
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Описание: Presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders - disorders featuring an increased susceptibility to infections and, in, certain conditions, an increased rate of malignancies and autoimmune disorders.

Автор: Jorge R. Oksenberg; David Brassat
Название: Immunogenetics of Autoimmune Disease
ISBN: 1489997482 ISBN-13(EAN): 9781489997487
Издательство: Springer
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Цена: 186330.00 T
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Описание: utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol­ ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent­ ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage­ ment approaches.