Biological Monitoring of Toxic Metals, Thomas W. Clarkson; Lars Friberg; Gunnar F. Nordbe
Автор: White Название: Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics ISBN: 1588295125 ISBN-13(EAN): 9781588295125 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Поставка под заказ. Описание: In this newly updated second edition of Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics, William B. White, MD, and a panel of highly experienced clinicians critically review every aspect of out-of-office evaluation of blood pressure, including home and ambulatory pressure, the relationship between whole-day blood pressure and the cardiovascular disease process, and the effects of numerous antihypertensive therapies on these blood pressure parameters. The world-class opinion leaders writing here describe the significant advances in our understanding of the circadian pathophysiology of cardiovascular disorders and demonstrate that ambulatory blood pressure values are independent predictors of cardiovascular morbidity and mortality.
Автор: Bernard Testa Название: Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies ISBN: 3906390225 ISBN-13(EAN): 9783906390222 Издательство: Wiley Рейтинг: Цена: 153120.00 T Наличие на складе: Невозможна поставка. Описание: In this age of combinatorial chemistry and high-throughput technologies, bioactive compounds called hits are discovered by the thousands. However, the road that leads from hits to lead compounds and then to pharmacokinetically optimized clinical and drug candidates is very long indeed. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming develop-ment and high rate of attrition of active compounds ultimately doomed by hidden pharmacokinetic defects, drug researchers are coming to incorporate structure-permeation, structure-distribution, structure-metabolism, and structure-toxicity relations into drug-design strategies. To this end, powerful biological, physicochemical, and computational approaches are being developed whose objectives are to increase the clinical relevance of drug design, and to eliminate as soon as possible compounds with unfavorable physicochemical properties and pharmacokinetic profiles. Toxicological issues are also of utmost importance in this paradigm. There was, hence, an urgent need for a book covering this field in an authoritative, didactic, comprehensive, factual, and conceptual manner. In this work of unique breadth and depth, international authorities and practicing experts from academia and industry present the most modern biological, physicochemical, and computational strategies to optimize gastrointestinal absorption, protein binding and distribution, brain permeation, and metabolic profile. The biological strategies emphasized in the book include cell cultures and high-throughput screens. The physicochemical strategies focus on the determination and interpretation of solubility, lipophilicity, and related molecular properties as factors and predictors of pharmacokinetic bahavior. Particular attention is paid to the lipophilicity profiles of ionized compounds, to lipophicity measurements in anisotropic media (liposomes/water, IAM columns), and to permeability across artificial membranes. Computational strategies comprise virtual screening, molecular modelling, lipophilicity, and H-bonding fields and their importance for structure-disposition relations. This book is both about theoretical and technological breakthroughs. Thus, molecular properties are contemplated from a dual perspective, namely a) their interpretation in biological and/or physicochemical terms, and b) their value in screening, lead optimization, and drug-candidate selection. In addition to its 33 chapters, the book includes a CD-ROM containing the invited lectures, oral communications and posters (in full version) presented at the Second LogP Symposium, 'Lipophilicity in Drug Disposition -- Practical and Computational Approaches to Molecular Properties Related to Drug Permeation, Disposition and Metabolism', held at the University of Lausanne in March 2000.
Автор: Hussain, Syed Sufyan Название: Insulin Pumps and Continuous Glucose Monitoring Made Easy ISBN: 0702061247 ISBN-13(EAN): 9780702061240 Издательство: Elsevier Science Рейтинг: Цена: 30310.00 T Наличие на складе: Поставка под заказ. Описание:
This innovative new guide to the diabetes technology introduces both insulin pumps and continuous glucose monitoring to the range of healthcare professionals involved in diabetes care. It is the first book of its kind and covers the principles and step by step implementation of state of the art devices to support people with diabetes. With interactive clinical cases and worked examples it will prove to be an invaluable, practical guide. It will also prove highly informative for diabetes patients.
Complete, up-to-date guide to insulin pump initiation and getting the most out of pump therapy
A clear framework for systematic interpretation and making the best use of continuous glucose monitoring data
Tips for managing challenging glucose patterns including exercise, alcohol and fasting
BONUS access to the complete downloadable eBook version on Expert Consult
Complete, up-to-date guide to insulin pump initiation and getting the most out of pump therapy
A clear framework for systematic interpretation and making the best use of continuous glucose monitoring data
Tips for managing challenging glucose patterns including exercise, alcohol and fasting
BONUS access to the complete downloadable eBook version on Expert Consult (with print edition)
Автор: Bernard Testa Название: Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies ISBN: 3906390357 ISBN-13(EAN): 9783906390352 Издательство: Wiley Рейтинг: Цена: 239660.00 T Наличие на складе: Поставка под заказ. Описание: Informatics and robotics are the workhorses of a technological revolution in drug research. On them are based combinatorial chemistry, which yields compounds by the many thousands, and high-throughput bioassays, which screen them for activity. The results are avalanches of `hits`, which invade the databases like swarms of locusts.
Автор: Y.H. Caplan; Amanda J. Jenkins Название: Drug Testing in Alternate Biological Specimens ISBN: 1617377325 ISBN-13(EAN): 9781617377327 Издательство: Springer Рейтинг: Цена: 186340.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Although the specimen of choice in the US drug testing industry is urine, and serum in clinical medicine, interest has recently grown in the use of other matrices as drug testing media. This book provides researchers and forensic toxicologists with a convenient general text summarizing the state of knowledge today.
Автор: Dasgupta Название: Handbook of Drug Monitoring Methods ISBN: 1617377732 ISBN-13(EAN): 9781617377730 Издательство: Springer Рейтинг: Цена: 144410.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.
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