Автор: Walsh Название: Antibiotics: Challenges, Mechanisms, Opportunities ISBN: 1555819303 ISBN-13(EAN): 9781555819309 Издательство: Wiley Рейтинг: Цена: 109770.00 T Наличие на складе: Поставка под заказ. Описание: Antibiotics: Challenges, Mechanisms, Opportunities details the contemporary challenges for discovery, optimization, and advancement of new antibiotics. It focuses on discovery not preclinical or clinical development. Given that the few classes of clinically significant antibiotics are all small molecules, this book focuses on the molecular structures and characteristics of both natural and synthetic antibacterial agents. Antibiotics is a valuable reference for microbiologists, bacterial physiologists, geneticists, pharmacologists, and drug developers. A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: • What are antibiotics? • Where do antibiotics come from?• How do antibiotics work? • Why do antibiotics stop working? • How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
Автор: Sass Название: Antibiotics ISBN: 1493966324 ISBN-13(EAN): 9781493966325 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume provides state-of-the-art and novel methods on antibiotic isolation and purification, identification of antimicrobial killing mechanisms, and methods for the analysis and detection of microbial adaptation strategies. Antibiotics: Methods and Protocols guides readers through chapters on production and design, mode of action, and response and susceptibility. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Antibiotics: Methods and Protocols aims to inspire scientific work in the exciting field of antibiotic research.
Автор: Moses Lee; D.P. Arya; T. Brown; M. Daneshtalab; J. Название: Heterocyclic Antitumor Antibiotics ISBN: 3642068146 ISBN-13(EAN): 9783642068140 Издательство: Springer Рейтинг: Цена: 222670.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
T. Brown, H. Holt Jr., M. Lee: Synthesis of Biologically Active Heterocyclic Stilbene and Chalcone Analogs of Combretastatin.-
J.T. Gupton: Pyrrole Natural Products with Antitumor Properties.-
Brian E. Love: Synthesis of Carbolines Possessing Antitumor Activity.-
D.P. Arya: Diazo and Diazonium DNA Cleavage Agents: Studies on Model Systems and Natural Product Mechanisms of Action.-
M. Daneshtalab: Novel Synthetic Antibacterial Agents.-
S.N. Maiti, R.P. Kamalesh Babu, R. Shan: Overcoming Bacterial Resistance: Role of -Lactamase Inhibitors
Автор: Arya Название: Aminoglycoside Antibiotics - From Chemical Biology to Drug Discovery ISBN: 047174302X ISBN-13(EAN): 9780471743026 Издательство: Wiley Рейтинг: Цена: 164680.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention.
Автор: Conte Название: Manual of Antibiotics and Infectious Diseases ISBN: 0781723167 ISBN-13(EAN): 9780781723169 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 36610.00 T Наличие на складе: Поставка под заказ. Описание: Manual of Antibiotics and Infectious Diseases: Treatment and Prevention was designed for health-care professionals involved in the daily care of patients with infectious diseases. The book covers antibiotics currently available, their doses, and their dose adjustments. It explains what to do when faced with renal failure, as well as empirical, prophylactic, and definitive antibiotic therapies--everything from bacteria resistance to AIDS therapies. A new section on hospital epidemiology and infection control is included in this Ninth Edition. A Brandon-Hill recommended title.
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