Moraes The Next Generation in Membrane Protein Structure Determination 9783319350707

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Автор: Moraes
Название: The Next Generation in Membrane Protein Structure Determination
ISBN: 9783319350707
Издательство: Springer
Классификация:

Биохимия

Белки

ISBN-10: 3319350706
Обложка/Формат: Hardback
Страницы: 184
Вес: 0.57 кг.
Дата издания: 2016
Серия: Advances in Experimental Medicine and Biology
Язык: English
Издание: 1st ed. 2016
Иллюстрации: 9 black & white illustrations, 64 colour illustrations, biography
Размер: 254 x 178 x 13
Читательская аудитория: General (us: trade)
Основная тема: Life Sciences
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects. Today, about 60% of the commercially available drugs target membrane proteins and it is estimated that nearly 30% of proteins encoded in the human genome are membrane proteins. In recent years much effort has been put towards innovative developments to overcome the numerous obstacles associated with the structure determination of membrane proteins. This book reviews a variety of recent techniques that are essential to any modern researcher in the field of membrane protein structural biology. The topics that are discussed are not commonly found in textbooks. The scope of this book includes: * Expression screening using fluorescent proteins * The use of detergents in membrane protein research * The use of NMR * Synchrotron developments in membrane protein structural biology * Visualisation and X-ray data collection of microcrystals * X-ray diffraction data analysis from multiple crystals * Serial millisecond crystallography * Serial femtosecond crystallography * Membrane protein structures in drug discovery The information provided in this book should be of interest to anyone working in the area of structural biology. Students will find carefully prepared overviews of basic ideas and advanced protein scientists will find the level of detail required to apply the material directly to their day to day work. Chapters 4, 5, 6, 8 and 9 of this book are published open access under a CC BY 4.0 license at link.springer.com.
Дополнительное описание: Expression Screening of Integral Membrane Proteins by Fusion to Fluorescent Reporters.- Detergents in Membrane Protein Purification and Crystallisation.- NMR of Membrane Proteins: Beyond Crystals.- Characterisation of Conformational and Ligand Binding Pro

The Next Generation in Membrane Protein Structure Determination, Moraes