Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting - cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituitary-gonadal axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation-related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress .
The Origin of Chronic Inflammatory Systemic Diseasesand Their Sequelae demonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging.
Автор: Asherson Название: Vascular Manifestations of Systemic Autoimmune Dis. ISBN: 084931335X ISBN-13(EAN): 9780849313356 Издательство: Taylor&Francis Рейтинг: Цена: 255200.00 T Наличие на складе: Невозможна поставка. Описание: Presents the clinical syndromes associated with small and large vessel pathology encountered in the autoimmune connective tissue disorders and includes the pathogenesis, clinical implications, and treatment of these diseases.
Автор: George C. Tsokos Название: Systemic Lupus Erythematosus ISBN: 0128019174 ISBN-13(EAN): 9780128019177 Издательство: Elsevier Science Рейтинг: Цена: 108080.00 T Наличие на складе: Поставка под заказ. Описание: Systemic Lupus Erythematosus combines basic science with clinical science to provide a translational treatment of the disease and is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.
Автор: Shoenfeld Название: Autoimmune Diseases & Treatment: Organ-Specific and Systemic Disorders. 2005 ISBN: 157331613X ISBN-13(EAN): 9781573316132 Издательство: Wiley Рейтинг: Цена: 125130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Only in very recent times have therapies been developed that are specific to a particular manifestation of autoimmune disease, and these have begun to replace the all-purpose remedies of the past 30 years.
Автор: Cubedo Cervera, Ricardo Название: Antiphospholipid Syndrome in Systemic Autoimmune Diseases,10 ISBN: 0444636552 ISBN-13(EAN): 9780444636553 Издательство: Elsevier Science Рейтинг: Цена: 143730.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Antiphospholipid Syndrome in Systemic Autoimmune Diseases, Second Edition provides an overview of our current understanding of this major disease. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations in both the thrombotic and non-thrombotic manifestations of this important disease.
Antiphospholipid syndrome is an autoimmune disease that causes abnormal blood clots. It is now recognized as a major cause of common conditions, including stroke, heart attack, miscarriage, epilepsy, and memory loss, and as such is gaining recognition in all branches of medicine, from obstetrics to cardiology, and from psychiatry to orthopedics.
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