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Design and Analysis of Cross-Over Trials, Third Edition, Jones


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Автор: Jones
Название:  Design and Analysis of Cross-Over Trials, Third Edition
ISBN: 9781439861424
Издательство: Taylor&Francis
Классификация:

ISBN-10: 1439861420
Обложка/Формат: Hardback
Страницы: 438
Вес: 0.77 кг.
Дата издания: 18.11.2014
Серия: Chapman & hall/crc monographs on statistics and applied probability
Язык: English
Издание: 3 ed
Иллюстрации: 200 tables, black and white; 51 illustrations, black and white
Размер: 242 x 169 x 28
Читательская аудитория: Tertiary education (us: college)
Ключевые слова: Probability & statistics, MATHEMATICS / Probability & Statistics / General,MEDICAL / Biostatistics,MEDICAL / Pharmacology
Основная тема: Statistical Theory & Methods
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание:

Design and Analysis of Cross-Over Trials is concerned with a specific kind of comparative trial known as the cross-over trial, in which subjects receive different sequences of treatments. Such trials are widely used in clinical and medical research, and in other diverse areas such as veterinary science, psychology, sports science, and agriculture.

The first edition of this book was the first to be wholly devoted to the subject. The second edition was revised to mirror growth and development in areas where the design remained in widespread use and new areas where it had grown in importance. This new Third Edition

  • Contains seven new chapters written in the form of short case studies that address re-estimating sample size when testing for average bioequivalence, fitting a nonlinear dose response function, estimating a dose to take forward from phase two to phase three, establishing proof of concept, and recalculating the sample size using conditional power
  • Employs the R package Crossover, specially created to accompany the book and provide a graphical user interface for locating designs in a large catalog and for searching for new designs
  • Includes updates regarding the use of period baselines and the analysis of data from very small trials
  • Reflects the availability of new procedures in SAS, particularly proc glimmix
  • Presents the SAS procedure proc mcmc as an alternative to WinBUGS for Bayesian analysis

Complete with real data and downloadable SAS code, Design and Analysis of Cross-Over Trials, Third Edition provides a practical understanding of the latest methods along with the necessary tools for implementation.



      Старое издание

Design and Analysis of Clinical Trials with Time-to-Event Endpoints

Название: Design and Analysis of Clinical Trials with Time-to-Event Endpoints
ISBN: 1420066390 ISBN-13(EAN): 9781420066395
Издательство: Taylor&Francis
Рейтинг:
Цена: 148010.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Provides a presentation of the design, monitoring, analysis, and interpretation of clinical trials in which time-to-event is of critical interest. This book discusses the design and monitoring of Phase II and III clinical trials with time-to-event endpoints.

Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition

Автор: Fairclough
Название: Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition
ISBN: 1420061178 ISBN-13(EAN): 9781420061178
Издательство: Taylor&Francis
Рейтинг:
Цена: 148010.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Presents a range of solutions to analytic issues. This title reflects developments in methodology with coverage of mixture models and a dataset example. It implements examples using SAS and R code and incorporates a number of examples from real QoL clinical trials to illustrate design and analysis methods.

Design and Analysis of Clinical Trials for Predictive Medicine

Автор: Matsui Shigeyuki
Название: Design and Analysis of Clinical Trials for Predictive Medicine
ISBN: 1466558156 ISBN-13(EAN): 9781466558151
Издательство: Taylor&Francis
Рейтинг:
Цена: 117390.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

Design and Analysis of Clinical Trials for Predictive Medicine provides statistical guidance on conducting clinical trials for predictive medicine. It covers statistical topics relevant to the main clinical research phases for developing molecular diagnostics and therapeutics--from identifying molecular biomarkers using DNA microarrays to confirming their clinical utility in randomized clinical trials.

The foundation of modern clinical trials was laid many years before modern developments in biotechnology and genomics. Drug development in many diseases is now shifting to molecularly targeted treatment. Confronted with such a major break in the evolution toward personalized or predictive medicine, the methodologies for design and analysis of clinical trials is now evolving.

This book is one of the first attempts to contribute to this evolution by laying a foundation for the use of appropriate statistical designs and methods in future clinical trials for predictive medicine. It is a useful resource for clinical biostatisticians, researchers focusing on predictive medicine, clinical investigators, translational scientists, and graduate biostatistics students.


Sustainability in the Design, Synthesis and Analysis of Chemical

Автор: Gerardo Ruiz Mercardo
Название: Sustainability in the Design, Synthesis and Analysis of Chemical
ISBN: 0128020326 ISBN-13(EAN): 9780128020326
Издательство: Elsevier Science
Рейтинг:
Цена: 101060.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: "

Sustainability in the Design, Synthesis and Analysis of Chemical Engineering Processes" is an edited collection of contributions from leaders in their field. It takes a holistic view of sustainability in chemical and process engineering design, and incorporates economic analysis and human dimensions. Ruiz- Mercado and Cabeza have brought to this book their experience of researching sustainable process design and life cycle sustainability evaluation to assist with development in government, industry and academia.

This book takes a practical, step-by-step approach to designing sustainable plants and processes by starting from the foundational chemical engineering fundamentals. This method enables readers to achieve new process design approaches with high influence and less complexity. It will also help you to incorporate sustainability at the early stages of project life, and build up multiple systems level perspectives. Ruiz-Mercado and Cabeza s book is the only book on the market that looks at process sustainability from a chemical engineering fundamentals perspective.
Improve plants, processes, and products with sustainability in mind; from conceptual design to life cycle assessmentIllustrates how to avoid retro fitting costs by planning for sustainability concerns at the start of the design processLinks sustainability to chemical engineering fundamentalsIncorporates economic analysis and human dimensions for a holistic view of sustainability in chemical and process engineering design"

Biorefineries and Chemical Processes: Design, Integration and Sustainability Analysis

Автор: Jhuma Sadhukhan,Kok Siew Ng,Elias Martinez Hernand
Название: Biorefineries and Chemical Processes: Design, Integration and Sustainability Analysis
ISBN: 1119990866 ISBN-13(EAN): 9781119990864
Издательство: Wiley
Рейтинг:
Цена: 93930.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: As the range of feedstocks, process technologies and products expand, biorefineries will become increasingly complex manufacturing systems. This book presents process modelling and integration, and whole system life cycle analysis tools for the synthesis, design, operation and sustainable development of biorefinery and chemical processes.

Quantitative Evaluation of Safety in Drug Development: Design, Analysis and Reporting

Автор: Jiang Qi, Xia H. Amy
Название: Quantitative Evaluation of Safety in Drug Development: Design, Analysis and Reporting
ISBN: 1466555459 ISBN-13(EAN): 9781466555457
Издательство: Taylor&Francis
Рейтинг:
Цена: 117390.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

State-of-the-Art Methods for Drug Safety Assessment

Responding to the increased scrutiny of drug safety in recent years, Quantitative Evaluation of Safety in Drug Development: Design, Analysis and Reporting explains design, monitoring, analysis, and reporting issues for both clinical trials and observational studies in biopharmaceutical product development. It presents the latest statistical methods for drug safety assessment.

The book's three sections focus on study design, safety monitoring, and data evaluation/analysis. The book addresses key challenges across regulatory agencies, industry, and academia. It discusses quantitative approaches to safety evaluation and risk management in drug development, covering Bayesian methods, effective safety graphics, and risk-benefit evaluation.

Written by a team of experienced leaders, this book brings the most advanced knowledge and statistical methods of drug safety to the statistical, clinical, and safety community. It shares best practices and stimulates further research and methodology development in the drug safety area.



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