Cancer Genetics and Genomics for Personalized Medicine,
Автор: Robert L. Nussbaum, Roderick R. McInnes Название: Thompson & Thompson Genetics in Medicine ISBN: 1437706967 ISBN-13(EAN): 9781437706963 Издательство: Elsevier Science Рейтинг: Цена: 36450.00 T Наличие на складе: Есть Описание:
Updated to reflect the newest changes in genetics, Thompson & Thompson's Genetics in Medicine returns as one of the most favored texts in this fascinating and rapidly evolving field. By integrating the classic principles of human genetics with modern molecular genetics, this medical reference book utilizes a variety of learning tools to help you understand a wide range of genetic disorders.
Acquire the state-of-the-art knowledge you need
on the latest advances in molecular diagnostics, the Human Genome Project, pharmacogenetics, and bio-informatics.
Better understand the relationship between basic genetics and clinical medicine with a variety of clinical case studies.
Recognize a wide range of genetic disorders with visual guidance from more than 240 dynamic illustrations and high-quality photos.
Immerse yourself in updated graphics
, full-color text, illustrations, line diagrams, and clinical photos of genetic diseases.
Explore the latest genetic content available in order to remain up to date on the most current trends in the field.
Take advantage of a double-page clinical case study section that demonstrates and reinforces general principles of disease inheritance, pathogenesis, diagnosis, management, and counseling.
Enhance your critical thinking skills and better retain information. Each chapter ends with up to 5 quick genetic problems related to what has just been reviewed, with answers provided in the back of the book.
Student Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. You'll also access USMLE-style and multiple choice questions.
Автор: Geoffrey S. Ginsburg Название: Genomic and Personalized Medicine, ISBN: 0123822270 ISBN-13(EAN): 9780123822277 Издательство: Elsevier Science Цена: 338970.00 T Наличие на складе: Невозможна поставка. Описание: Genomic and Personalized Medicine, Second Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Medicine - is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine.
With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. * Highly Commended 2013 BMA Medical Book Award for Medicine* More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition* Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics* Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine* Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis
Автор: Geoffrey S. Ginsburg Название: Genomic and Personalized Medicine ISBN: 0128006811 ISBN-13(EAN): 9780128006818 Издательство: Elsevier Science Рейтинг: Цена: 101050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care.
The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care.
Provides a comprehensive volume on the translation and implementation of biology into health care provision
Presents succinct commentary and key learning points that will assist readers with their local needs for translation and implementation
Includes an up-to-date overview on major 'translational events' in genomic and personalized medicine, along with lessons learned
Автор: Da Yong Lu Название: Personalized Cancer Chemotherapy ISBN: 0081003463 ISBN-13(EAN): 9780081003466 Издательство: Elsevier Science Рейтинг: Цена: 154960.00 T Наличие на складе: Невозможна поставка. Описание:
Personalized Cancer Chemotherapy separately describes and addresses "individualized cancer chemotherapy" (ICC) strategies new and old, to provide readers with new insights into their characteristics and techniques, as well as key debates and future trends in this area. The book devotes chapters to drug sensitivity testing, cancer biomarkers and bioinformatics detection, pharmacogenetics, individualized antimetastatic therapy, drug combinations, assistant chemotherapy, and cost-effectiveness considerations.
A major obstacle to controlling cancer growth and metastases in patients is the inappropriate use of anticancer and antimetastatic drugs. Researchers and clinicians are now beginning to focus on ICC also called "personalized cancer chemotherapy" (PCC), to improve therapeutic quality and outcomes by selecting and prescribing the most appropriate and effective drugs. Using genetic, molecular, and bioinformatics data and modern experimental techniques, known tumor genes can be detected more easily than ever before; the average speed of genetic sequencing has increased 15,000 to 50,000 times since the Human Geonme Project was completed.
This book will help readers understand the pros and cons of each individualized cancer chemotherapy strategy from different angles so as to make good judgments and predictions of drug responses and clinical outcomes.
Explores the central components of cancer treatment
Investigates new developments in cancer treatment
Discusses the many strategies of individualized cancer chemotherapy
Автор: Trygve Tollefsbol Название: Personalized Epigenetics ISBN: 0124201350 ISBN-13(EAN): 9780124201354 Издательство: Elsevier Science Рейтинг: Цена: 93200.00 T Наличие на складе: Невозможна поставка. Описание:
Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy.
The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.
Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.
Автор: Sweet, Kevin M., Michaelis, Ron C Название: The busy physician`s guide to genetics, genomics and personalized medicine ISBN: 9400711468 ISBN-13(EAN): 9789400711464 Издательство: Springer Рейтинг: Цена: 174150.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In the coming decade, the focus of medicine will shift from a disease-oriented approach, where the physician prescribes according to the disease the patient has, to a personalized approach, in which the physician first considers the patient’s individual biochemistry before prescribing a treatment. Personalized medicine has the potential to improve efficacy and safety in virtually all fields of medicine. Unfortunately, few physicians feel confident in their ability to apply the principles of genetics and genomics upon which personalized medicine is based to their practice. This book is intended to help the practicing physician understand and apply the principles of genetic and genomic medicine, regardless of his/her level of background in the field. It provides a thorough foundation/review of classical genetic principles, with an emphasis on how these principles apply to personalized medicine and common complex diseases. In addition, it provides a wide-ranging review of the inroads that personalized medicine has made into several fields, including cancer, psychiatric disorders, cardiovascular disease, substance abuse, Alzheimer disease, respiratory diseases, type 2 diabetes and macular degeneration. Most importantly, this book is intended to enable the practicing physician, physician assistants and their entire healthcare team to anticipate the developments that will emerge in the near future, and stay current with the field as it expands.
Автор: Tan, Dongfeng Название: Principles of Molecular Diagnostics and Personalized Cancer Medicine ISBN: 1451131976 ISBN-13(EAN): 9781451131970 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 250530.00 T Наличие на складе: Поставка под заказ. Описание: Principles of Molecular Diagnostics and Personalized Cancer Medicine" The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care. Improve your understanding of… • The basic mechanisms of carcinogenesis— including material on cell proliferation, signal transduction pathways, cancer stem cells, and the interaction between genetics and environmental factors. • The most current molecular techniques —including polymerase chain reaction (PCR) technique, single nucleotide polymorphisms, cancer cytogenomics and epigenetics, whole-genome assessments, and next- generation sequencing. • Molecular tests —including molecular screening, minimal residual disease detection, circulating tumor cell tests, molecular tumor staging, and molecular cancer prognosis assessment. • Imaging and screening technologies —including molecular imaging, genetic tests, biostatistics, and bioinformatics. • The molecular basis of therapy —including critical molecules as special treatment targets, particularly genes/DNA, RNA, micro RNAs, proteins/antibodies, and nanoparticles. • Molecular diagnostics – including updated molecular diagnostic approaches to common malignancies and role of pathology in targeted cancer management. • Targeted treatment – including personalized medicine and targeted therapy for commonly occurring malignancies— plus insights on new approaches to targeted drug discovery and the future of molecular oncology!
Автор: D. Hunter Best; Jeffrey J. Swensen Название: Molecular Genetics and Personalized Medicine ISBN: 1627039236 ISBN-13(EAN): 9781627039239 Издательство: Springer Рейтинг: Цена: 186340.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book reviews developments in molecular genetics, showing how they have been adopted in clinical practice. The authors simplify complex genetic concepts and focus on patient related issues. The aim is to help shorten the time from lab bench to bedside.
Автор: Snyder Michael Название: Genomics and Personalized Medicine: What Everyone Needs to Know(r) ISBN: 0190234768 ISBN-13(EAN): 9780190234768 Издательство: Oxford Academ Рейтинг: Цена: 11610.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In 2001 the Human Genome Project succeeded in mapping the DNA of humans. This landmark accomplishment launched the field of genomics, the integrated study of all the genes in the human body and the related biomedical interventions that can be tailored to benefit a person's health. Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual's genetic sequence -- their genome -- against known elements of "Big Data," elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is limitless. This entry in the What Everyone Needs to Know series offers an authoritative resource on the prospects and realities of genomics and personalized medicine. As this science continues to alter traditional medical paradigms, consumers are faced with additional options and more complicated decisions regarding their health care. This book provides the essential information everyone needs.
Автор: Snyder, Michael Название: Genomics and Personalized Medicine ISBN: 0190234776 ISBN-13(EAN): 9780190234775 Издательство: Oxford Academ Рейтинг: Цена: 50680.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual`s genetic sequence - their genome - against known elements of "Big Data," elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution islimitless.
Название: Towards Personalized Medicine for Cancer ISBN: 1573318159 ISBN-13(EAN): 9781573318150 Издательство: Wiley Рейтинг: Цена: 35640.00 T Наличие на складе: Поставка под заказ. Описание: This volume explores cancer as an individualized problem and addresses the impact of recent advances in cancer biology, genetics, tumor profiling, and medical technology in the personalization of cancer predisposition, diagnosis, prognosis, treatment, and therapy development.
Автор: Geoffrey S. Ginsburg Название: Essentials of Genomic and Personalized Medicine, ISBN: 0123749344 ISBN-13(EAN): 9780123749345 Издательство: Elsevier Science Рейтинг: Цена: 101200.00 T Наличие на складе: Невозможна поставка. Описание: Derived from the comprehensive two-volume set, <i>Genomic and Personalized Medicine</i> also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, <i>Essentials of Genomic and Personalized Medicine</i> will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine. <br><br>* Full color throughout<br>* Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field <br>* Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practice<br>* Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science
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