Small-Molecule Transcription Factor Inhibitors in Oncology, 

Автор: Etsuko Miyamoto-Sato; Hiroyuki Ohashi; Hirotaka Sa
Название: Transcription Factor Regulatory Networks
ISBN: 1493908049 ISBN-13(EAN): 9781493908042
Издательство: Springer
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Цена: 149060.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Transcription Factor Regulatory Methods details various techniques ranging from cutting-edge to general techniques use to study transcription factor regulatory networks.

Автор: Thorsten Will
Название: Predicting Transcription Factor Complexes
ISBN: 3658082682 ISBN-13(EAN): 9783658082680
Издательство: Springer
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Цена: 93160.00 T
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Описание: In his master thesis Thorsten Will proposes the substantial information content of protein complexes involving transcription factors in the context of gene regulatory networks, designs the first computational approaches to predict such complexes as well as their regulatory function and verifies the practicability using data of the well-studied yeast S.cereviseae. The novel insights offer extensive capabilities towards a better understanding of the combinatorial control driving transcriptional regulation.

Автор: Rakesh Kumar
Название: Nuclear Signaling Pathways and Targeting Transcription in Cancer
ISBN: 1461480388 ISBN-13(EAN): 9781461480389
Издательство: Springer
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Цена: 156720.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book summarizes the roles, significance, and potential therapeutic targeting of transcriptional factors (TFs) from the perspective of signaling cascade. It details the physiologic and pathologic roles of TFs in specific representative organ systems.

Автор: Frank J. III Rauscher; Peter K. Vogt
Название: Chromosomal Translocations and Oncogenic Transcription Factors
ISBN: 3642644244 ISBN-13(EAN): 9783642644245
Издательство: Springer
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Цена: 121110.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type.

Автор: Ganji Purnachandra Nagaraju; Pallaval Veera Bramha
Название: Role of Transcription Factors in Gastrointestinal Malignancies
ISBN: 9811338930 ISBN-13(EAN): 9789811338939
Издательство: Springer
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Цена: 139750.00 T
Наличие на складе: Нет в наличии.
Описание: This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery.

Автор: Rakesh Kumar
Название: Nuclear Signaling Pathways and Targeting Transcription in Cancer
ISBN: 1493901125 ISBN-13(EAN): 9781493901128
Издательство: Springer
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Цена: 139310.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book summarizes the roles, significance, and potential therapeutic targeting of transcriptional factors (TFs) from the perspective of signaling cascade. It details the physiologic and pathologic roles of TFs in specific representative organ systems.

Автор: Satya Prakash Gupta
Название: Cancer-Causing Viruses and Their Inhibitors
ISBN: 1138374830 ISBN-13(EAN): 9781138374836
Издательство: Taylor&Francis
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Цена: 60220.00 T
Наличие на складе: Невозможна поставка.
Описание:

Cancer-causing viruses, also called oncoviruses, play a key role in the development of certain cancers. They contribute to genetic changes that disrupt the cell cycle machinery, interfering with functions such as cell growth. Cancer-Causing Viruses and Their Inhibitors presents a plethora of research from internationally reputed contributors who discuss different types of oncoviruses, their mechanisms of invasion and growth, and their life cycles.

The book begins with an overview of the oncoviruses discovered to date and includes a brief description of their structures, genotypes, replication, and mechanisms of infection leading to cancers. It then explores several of these viruses in detail, including:

• Human T-cell leukemia virus type 1 (HTLV-1)
• Hepatitis C virus (HCV)
• Epstein-Barr virus (EBV)
• Human papilloma virus (HPV)
• Human herpes virus 8 (HHV-8)/Kaposi's sarcoma-associated herpes virus (KSHV)
• Human immunodeficiency virus (HIV/AIDS)
• Oncolytic viruses

This book is an essential reference for those working in virology, oncology, and biotechnology. The discoveries presented will enable researchers and clinicians to optimize both historical and current approaches to anti-viral therapies.

Автор: Ingo K. Mellinghoff; Charles L. Sawyers
Название: Therapeutic Kinase Inhibitors
ISBN: 3642445802 ISBN-13(EAN): 9783642445804
Издательство: Springer
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Цена: 174130.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as chemotherapy and still the backbone of most cancer treatment regimens, are increasingly being complemented by or replaced with kinase inhibitors. This new class of drugs targets enzymes which provide growth and survival signals to cancer cells by transferring phosphate groups from Adenosine-5'-triphosphate (ATP) to other proteins, lipids, nucleotides, and carbohydrates.

This book summarizes the current state of kinase inhibitor therapy for cancer. Successful drug development relies on the expertise and dedication of many experts. To reflect this team approach to finding new kinase inhibitors and defining their optimal use for cancer treatment, the editorsinvited experts in academia and pharmaceutical industry to share their insights into various aspects of this process, ranging from the first chemical screens, to preclinical testing and disease-focused clinical drug development. The editors and authorshope these lessons will be instructive for the novice as well as the expert. "