Автор: Randall J. Mrsny, Ann Daugherty Название: Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes ISBN: 1420078062 ISBN-13(EAN): 9781420078060 Издательство: Taylor&Francis Рейтинг: Цена: 128620.00 T Наличие на складе: Есть Описание: Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is an invaluable source for drug discovery and development scientists in the biopharmaceutical industry who frequently navigate the maze of protein and peptide pharmacokinetics, pharmacodynamics, and metabolism.
Key features include:
issues related to delivery of protein and peptide therapeutics in elderly populations and pharmacogenomics
lessons learned on the major marketed areas of proteins and peptides, including interleukins, interferons, growth factors, and peptide hormones
innovations for protein and peptide delivery such as needle-less delivery
strategies for delivery of these molecules to locations such as the eye and brain
generic issues of proteins and peptides
Автор: Seyfried Название: Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer ISBN: 0470584920 ISBN-13(EAN): 9780470584927 Издательство: Wiley Рейтинг: Цена: 131950.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg`s well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited.
Автор: Hoffmann, Georg F.; Zschocke, Johannes; Nyhan, William L. (Eds.) Название: Inherited Metabolic Diseases: a clinical Approach. ISBN: 3540747222 ISBN-13(EAN): 9783540747222 Издательство: Springer Цена: 107130.00 T Наличие на складе: Поставка под заказ.
Автор: Jens Nielsen Название: Metabolic Engineering (Advances in Biochemical Engineering/Biotechnology) ISBN: 3540418482 ISBN-13(EAN): 9783540418481 Издательство: Springer Рейтинг: Цена: 261210.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This work reviews developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity in the production of polyketides and extension of the substrate range.
Автор: Hosking Md Frcp Название: Treatment of Metabolic Bone Disease ISBN: 1853177555 ISBN-13(EAN): 9781853177552 Издательство: Informa Цена: 46600.00 T Наличие на складе: Нет в наличии. Описание: A comprehensive review of pharmacologic treatments for metabolic bone disease.
Автор: Gregory Stephanopoulos Название: Metabolic Engineering, ISBN: 0126662606 ISBN-13(EAN): 9780126662603 Издательство: Elsevier Science Рейтинг: Цена: 167030.00 T Наличие на складе: Поставка под заказ. Описание:
Metabolic engineering is a new field with applications in the production of chemicals, fuels, materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the synthesis of molecular biology techniques and the tools of mathematical analysis, which allow rational selection of targets for genetic modification through measurements and control of metabolic fluxes. The objective is to identify specific genetics or environmental manipulations that result in improvements in yield and productivities of biotechnological processes.
Key features of the book are pathway integration and the focus on metabolic flux as a fundamental determinant of cell physiology. The book keeps mathematical complexity to a minimum, and provides a glossary of biological terms to facilitate use of the book by a broader spectrum of readers. A web page exists to communicate updates of the codes and homework problems.
Автор: Cheng (Ed) Название: Microbial Metabolic Engineering (Methods in Molecular Biology 834) ISBN: 1617794821 ISBN-13(EAN): 9781617794827 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Metabolic engineering is the practice of genetically optimizing metabolic and regulatory networks within cells to increase production and/or recovery of certain substance from cells. In Microbial Metabolic Engineering: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study metabolic engineering. These include methods and techniques to engineer genes and pathways, use of modern biotechnology tools in microbial metabolic engineering, and examples of metabolic engineering for real world applications such as whole cell biosensors and acetate control in large scale fermentation. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Microbial Metabolic Engineering: Methods and Protocols seeks to provide researchers with an overview of key topics on microbial metabolic engineering.
Автор: Verpoorte R., Alfermann A.W., Johnson T.S. Название: Applications of Plant Metabolic Engineering ISBN: 1402060300 ISBN-13(EAN): 9781402060304 Издательство: Springer Рейтинг: Цена: 191560.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Written by leading international experts in the field of plant metabolic engineering, this book discusses, mainly, applications of plant metabolic engineering. Metabolic engineering, which is part of second generation biotechnology, has made several contributions at basic level as well as at conceptualising products ever since its emergence in the early 1980s. Applications resulting from metabolic engineering are expected to play a very important role in future for plant breeding, e.g. for improved resistance or improved traits concerning health promoting constituents, and production of fine chemicals such as medicines, flavors and fragrances. Considering the tremendous progress that has been made since our first book in the year 2000 urgency was felt to bring together cutting edge research in plant metabolic engineering in applied aspects as a handy reference book. This book has been predominantly dedicated to applied research of metabolic engineering, and a part of it has been allotted for fundamental research that has potential applications. This book is a unique source of information for all those involved with plants as chemical factories of fine chemicals and also to more experienced scientists who work on transgenic plants, besides, senior researchers, graduate students, post-doctroral students, teachers and students as well.
Автор: Bray, George A.|| Bray, George A.|| Название: A Guide to Obesity and the Metabolic Syndrome ISBN: 1439814570 ISBN-13(EAN): 9781439814574 Издательство: Taylor&Francis Рейтинг: Цена: 209270.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
In the historical record there is abundant evidence that obesity was a medical and health concern as long as medicine has been practiced. The idea of diet and exercise are bulwarks in the fight against obesity in history from the time of Hippocrates to the 16th century--a span of 2,000 years. However, our scientific understanding of this problem is only a little over 200 years old. An examination of the root cause of what many consider the obesity epidemic, A Guide to Obesity and the Metabolic Syndrome traces the origins and types of obesity and its treatment.
Examining in detail the developing treatment for obesity, this book provides:
A history of obesity, including treatment, proposed causes, and perceptions
An examination of the causes and problems associated with obesity
A discussion of lifestyle, diet, exercise, and treatment strategies
A detailed look at the medications and surgeries available for obesity
The fact that we have an epidemic of obesity today that is covering the globe suggests that the strategically simple ideas of eating less and exercising more, ideas that require commitment and personal involvement by the individual, have not been very successful. As we move forward in trying to understand this problem, we need to be alert to strategies and tactics that may not require individual motivation and commitment--history has shown that they do not work well. This book supplies guidance on developing and designing novel strategic interventions against obesity and metabolic disorders.
Автор: Jeffrey K. Aronson Название: Meyler`s Side Effects of Endocrine and Metabolic Drugs, ISBN: 0444532714 ISBN-13(EAN): 9780444532718 Издательство: Elsevier Science Рейтинг: Цена: 56130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Endocrine and metabolic diseases are common, includes diseases such as diabetes, thyroid disease, and obesity. Suitable for any health professional involved in the administration of endocrine and metabolics mediations, this title surpasses the Physician`s Desk Reference by including clinical case studies and independent expert analysis.
Автор: Shimizu Название: Metabolic regulation and metabolic engineeing for biofuel and biochemical and biochemical production ISBN: 1498768377 ISBN-13(EAN): 9781498768375 Издательство: Taylor&Francis Рейтинг: Цена: 193950.00 T Наличие на складе: Невозможна поставка. Описание: The global warming problem is becoming critical year by year, causing climate disaster all over the world, where it has been believed that the CO2 gas emitted from the factories and the burning of fossil fuels may be one of the reasons of global warming. Moreover, the global stock of fossil fuels is limited, and may run out soon within several tens of years. Although wind, geo-thermal, and tide energies have been considered as clean energy sources, those depend on the land or sea locations and subject to the climate change. Biofuel and biochemical production from renewable bio-resources has thus been paid recent attention from environmental protection and energy production points of view, where the current chemical and energy producing plants can be also utilized with slight modification. The so-called 1st generation biofuels have been produced from corn starch and sugarcane in particular in USA and Brazil. However, this causes the problem of the so-called "food and energy issues" as the production scale increases. The 2nd generation biofuel production from lingo-cellulosic biomass or wastes has thus been paid recent attention. However, it requires energy intensive pretreatment for the degradation of lingo-cellulosic biomass, and the fermentation is slow due to low growth rate, and thus the productivity of biofuels and bio-chemicals is low. The 3rd generation biofuel production from photosynthetic organisms such as cyanobacteria and algae has been also paid attention, because such organisms can grow with only sun light and CO2 in the air, but the cell growth rate and thus the productivity of the fuels is significantly low. The main part or core of such production processes is the fermentation by micro-organisms. In particular, it is critical to properly understand the cell metabolism followed by the efficient metabolic engineering. The book gives comprehensive explanation of the cell metabolism and the metabolic regulation mechanisms of a variety of micro-organisms. Then the efficient metabolic engineering approaches are explained to properly design the microbial cell factories for the efficient cell growth and biofuel and biochemical production.
Автор: Lammerhofer Название: Metabolomics in Practice: Successful Strategies to Generate and Analyze Metabolic Data ISBN: 3527330895 ISBN-13(EAN): 9783527330898 Издательство: Wiley Рейтинг: Цена: 99210.00 T Наличие на складе: Поставка под заказ. Описание: Unlike other handbooks in this emerging field, this guide focuses on the challenges and critical parameters in running a metabolomics study, including such often-neglected issues as sample preparation, choice of separation and detection method, recording and evaluating data as well as method validation.
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