Автор: Israel A., Strooper B. de, Checler F., Christen Y.
Название: Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate
ISBN: 3540430733 ISBN-13(EAN): 9783540430735
Издательство: Springer
Рейтинг:
Цена: 104490 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms. One such signaling mechanism, the Notch pathway, has been recognized as an important player in the regulation of cellfate decisions during early neural development. However, the action of this evolutionary conserved and widely used cell-cell interaction mechanism is not confined to the developing nervous system. In addition, recent studies have shown that elucidating the mechanism of Notch signaling and its role in the brain is important for our understanding of neurological disorders such as Alzheimer's disease and cerebral arteriopathy CADASIL.

Автор: L Susmel
Название: Multiaxial Notch Fatigue,
ISBN: 1845695828 ISBN-13(EAN): 9781845695828
Издательство: Elsevier Science
Цена: 126500 T
Наличие на складе: Поставка под заказ.
Описание: Metal and composite components used in structural engineering not only contain geometrical features resulting in stress concentration phenomena, but they are also subjected to in-service multiaxial fatigue loading. To address the problem, structural engineers need reliable methodologies which allow for an adequate margin of safety. The book summarises methods devised by the author to design real components against multiaxial fatigue by taking full advantage not only of nominal but also of local stress-strain quantities.

The book begins by reviewing definitions suitable for calculating the stress-strain quantities commonly used to perform fatigue assessment. The Modified W hler Curve Method is then explained in detail, by focusing attention on both the high- and the medium-cycle fatigue regime. The existing links between the multiaxial fatigue criterion and physical properties are also discussed. A procedure suitable for employing the method developed by the author to estimate fatigue damage both in notched and in welded components is explained. The Modified Manson-Coffin Curve method is investigated in depth, by reviewing those concepts playing a fundamental role in the so-called strain based approach. Lastly, the problem of performing the fatigue assessment of composite materials is addressed by considering design parameters influencing composite behaviour under complex cyclic loading paths and those criteria suitable for designing real components against multiaxial fatigue. The book also contains two appendices summarising experimental data from the technical literature. These appendices provide a unique and highly valuable resource for engineers. The appendices summarise around 100 values of the material characteristic length L, experimentally determined by testing specimens made of different engineering materials and about 4500 experimental fatigue results generated by testing plain, notched and welded specimens under constant-amplitude proportional and non-proportional multiaxial fatigue loading are listed.

• Summarises methods devised by the author to design real components against multiaxial fatigue
• Reviews definitions suitable for calculating the stress-strain quantities commonly used to perform fatigue assessment
• Includes an in-depth explanation of both the Modified W hler Curve and Modified Manson-Coffin Curve Method

Автор: Reichrath
Название: Notch Signaling in Embryology and Cancer
ISBN: 1461408989 ISBN-13(EAN): 9781461408987
Издательство: Springer
Рейтинг:
Цена: 118220 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. Experts in the field as well as scientists and health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for every clinician or scientist interested in the role of Notch signalling in embryology and cancer. We hope that this volume will be adopted as the standard text in this area of science and will stimulate new interest in the role of Notch signalling for embryology and cancer. We further hope that this compendium will serve as both a source for current researchers and a guide to stimulate and assist those in related disciplines to enter this exciting field of research.

Автор: Radtke
Название: Notch Regulation of the Immune System
ISBN: 3642242936 ISBN-13(EAN): 9783642242939
Издательство: Springer
Рейтинг:
Цена: 92510 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system.  This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia.

Автор: Raphael Kopan
Название: Notch Signalling,92
ISBN: 0123809142 ISBN-13(EAN): 9780123809148
Издательство: Elsevier Science
Рейтинг:
Цена: 93500 T
Наличие на складе: Поставка под заказ.
Описание: Provides researchers with an overview and synthesis of the various research findings and contemporary thought in the area of Notch Signaling. This title covers topics such as Notch signaling in Cardiac development and disease, and Notch in Stem Cells.

Автор: Pluvinage G., Gjonaj Marenglen
Название: Notch Effects in Fatigue and Fracture
ISBN: 0792368428 ISBN-13(EAN): 9780792368427
Издательство: Springer
Рейтинг:
Цена: 57740 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The particular emphasis of this book is on new approaches to the notch effect problem in fatigue and fracture, and in particular the volumetric approach. These new methods are introduced in an attempt to replace the hot spot method, which suffers from some degree of empiricism. The work has given rise to a new field: notch fracture mechanics, in which a crack is considered as a particular case of a notch. Theoretical and practical aspects are presented in both fracture and fatigue. Special attention is paid to welded joints. Readership: Particularly recommended to engineers involved in safety design. Readers should possess adequate skill in strength of materials and fracture mechanics.

Автор: Pluvinage G., Gjonaj Marenglen
Название: Notch Effects in Fatigue and Fracture
ISBN: 079236841X ISBN-13(EAN): 9780792368410
Издательство: Springer
Рейтинг:
Цена: 120450 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The particular emphasis of this book is on new approaches to the notch effect problem in fatigue and fracture, and in particular the volumetric approach. These new methods are introduced in an attempt to replace the hot spot method, which suffers from some degree of empiricism. The work has given rise to a new field: notch fracture mechanics, in which a crack is considered as a particular case of a notch. Theoretical and practical aspects are presented in both fracture and fatigue. Special attention is paid to welded joints. Readership: Particularly recommended to engineers involved in safety design. Readers should possess adequate skill in strength of materials and fracture mechanics.

Название: Multiaxial notch fatigue
ISBN: 1439803013 ISBN-13(EAN): 9781439803011
Издательство: Taylor&Francis
Рейтинг:
Цена: 67210 T
Наличие на складе: Поставка под заказ.
Описание: A summary of methods for designing real components against multiaxial fatigue, this book explains the Modified Wohler Curve Method, focusing attention on both the high- and the medium-cycle fatigue regime, and discusses the existing links between the multiaxial fatigue criterion and physical properties. The author explains how to employ the method he developed to estimate fatigue damage in notched and welded components. He investigates the Modified Manson-Coffin Curve method and includes about 4500 experimental fatigue results generated by testing plain, notched, and welded specimens under constant-amplitude proportional and non-proportional multiaxial fatigue loading.