Metabolism and Functions of Bioactive Ether Lipids in the Brain, Farooqui

Автор: Jacques Fantini
Название: Brain Lipids in Synaptic Function and Neurological Disease
ISBN: 0128001119 ISBN-13(EAN): 9780128001110
Издательство: Elsevier Science
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Цена: 104410.00 T
Наличие на складе: Невозможна поставка.
Описание:

Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer's, Creutzfeldt-Jakob's and Parkinson's. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders.