Multiple Testing Procedures with Applications to Genomics, Sandrine Dudoit; Mark J. van der Laan
Автор: Dudoit Название: Multiple Testing Procedures with Applications to Genomics ISBN: 0387493166 ISBN-13(EAN): 9780387493169 Издательство: Springer Рейтинг: Цена: 191560.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. The methods are applied to a range of testing problems in biomedical and genomic research, including the identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments, such as microarray experiments; tests of association between gene expression measures and biological annotation metadata (e.g., Gene Ontology); sequence analysis; and the genetic mapping of complex traits using single nucleotide polymorphisms. The book is aimed at both statisticians interested in multiple testing theory and applied scientists encountering high-dimensional testing problems in their subject matter area. Specifically, the book proposes resampling-based single-step and stepwise multiple testing procedures for controlling a broad class of Type I error rates, defined as tail probabilities and expected values for arbitrary functions of the numbers of Type I errors and rejected hypotheses (e.g., false discovery rate). Unlike existing approaches, the procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions (with arbitrary dependence structures among variables), null hypotheses, and test statistics. The multiple testing results are reported in terms of rejection regions, parameter confidence regions, and adjusted p-values.
Автор: Duane E. Haines Название: Fundamental Neuroscience for Basic and Clinical Applications, ISBN: 1437702945 ISBN-13(EAN): 9781437702941 Издательство: Elsevier Science Рейтинг: Цена: 70730.00 T Наличие на складе: Невозможна поставка. Описание: Includes coverage of neuroanatomy, physiology, and pharmacology, with a particular emphasis on systems neurobiology, effectively prepares you for your courses, exams, and beyond.
Название: Forensic DNA applications ISBN: 1466580224 ISBN-13(EAN): 9781466580220 Издательство: Taylor&Francis Рейтинг: Цена: 148010.00 T Наличие на складе: Невозможна поставка. Описание:
Forensic DNA Applications: An Interdisciplinary Perspective was developed as an outgrowth of a conference held by the International Society of Applied Biological Sciences. The topic was human genome-based applications in forensic science, anthropology, and individualized medicine. Assembling the contributions of contributors from numerous regions around the world, this volume is designed as both a textbook for forensic molecular biology students and a reference for practitioners and those in the legal system.
The book begins with the history and development of DNA typing and profiling for criminal and civil purposes. It discusses the statistical interpretation of results with case examples, mitochondrial DNA testing, Y single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs), and X SNP and STR testing. It also explores low copy number DNA typing, mixtures, and quality assurance and control.
The second section examines the collection and preservation of biological evidence under a variety of different circumstances and the identification of human remains--including in mass disaster settings. It discusses applications to bioterrorism investigations, animal DNA testing in criminal cases, pedigree questions and wildlife forensic problems, applications in forensic entomology, and forensic botany.
The third section explores recent developments and new technologies, including the rigorous identification of tissue of origin, mtDNA profiling using immobilized probe strips, chips and next-generation sequencing, the use of SNPs to ascertain phenotypic characteristics, and the "molecular autopsy" that looks at aspects of toxicogenetics and pharmacogenetics.
The book concludes with a discussion on law, ethics, and policy. It examines the use of DNA evidence in the criminal justice system in both the United States and Europe, ethical issues
in forensic laboratory practices, familial searches, DNA databases, ancestry searches, physical phenotyping, and report writing. The contributors also examine DNA applications in immigration and human trafficking cases and international perspectives on DNA databases.
Автор: van Blerkom Jonathan, Gregory Linda Название: Essential IVF / Basic Research and Clinical Applications ISBN: 1402075510 ISBN-13(EAN): 9781402075513 Издательство: Springer Рейтинг: Цена: 222670.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The topics selected for this volume include research that has begun to explain the origins of differential follicular, gamete, embryo and uterine competence, and specific laboratory procedures and protocols that may have important clinical implications forthe generation ofdevelopmentally viable embryos.
Название: Data Mining and Applications in Genomics ISBN: 1402089740 ISBN-13(EAN): 9781402089749 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Data Mining and Applications in Genomics contains the data mining algorithms and their applications in genomics, with frontier case studies based on the recent and current works at the University of Hong Kong and the Oxford University Computing Laboratory, University of Oxford.
Название: Data Mining and Applications in Genomics ISBN: 9048180406 ISBN-13(EAN): 9789048180400 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Data Mining and Applications in Genomics contains the data mining algorithms and their applications in genomics, with frontier case studies based on the recent and current works at the University of Hong Kong and the Oxford University Computing Laboratory, University of Oxford.
Автор: Chung S.H., Andersen O.S., Krishnamurthy V. Название: Biological Membrane Ion Channels / Dynamics, Structure, and Applications ISBN: 0387333231 ISBN-13(EAN): 9780387333236 Издательство: Springer Рейтинг: Цена: 204040.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Deals with breakthroughs in ion-channel research that have been brought about by joint efforts of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these designed biomolecules. This book is aimed at researchers in nanodevices and biosensors, undergraduate and graduate students in biology.
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